Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative)

M. Fernanda Lima-Costa, Laura C. Rodrigues, Maurício L. Barreto, Mateus Gouveia, Bernardo L. Horta, Juliana Mambrini, Fernanda S G Kehdy, Alexandre Pereira, Fernanda Rodrigues-Soares, Cesar G. Victora, Eduardo Tarazona-Santos, Epigen-Brazil group

Research output: Contribution to journalArticle

Abstract

Brazil never had segregation laws defining membership of an ethnoracial group. Thus, the composition of the Brazilian population is mixed, and its ethnoracial classification is complex. Previous studies showed conflicting results on the correlation between genome ancestry and ethnoracial classification in Brazilians. We used 370,539 Single Nucleotide Polymorphisms to quantify this correlation in 5,851 community-dwelling individuals in the South (Pelotas), Southeast (Bambui) and Northeast (Salvador) Brazil. European ancestry was predominant in Pelotas and Bambui (median = 85.3% and 83.8%, respectively). African ancestry was highest in Salvador (median = 50.5%). The strength of the association between the phenotype and median proportion of African ancestry varied largely across populations, with pseudo R(2) values of 0.50 in Pelotas, 0.22 in Bambui and 0.13 in Salvador. The continuous proportion of African genomic ancestry showed a significant S-shape positive association with self-reported Blacks in the three sites, and the reverse trend was found for self reported Whites, with most consistent classifications in the extremes of the high and low proportion of African ancestry. In self-classified Mixed individuals, the predicted probability of having African ancestry was bell-shaped. Our results support the view that ethnoracial self-classification is affected by both genome ancestry and non-biological factors.

Original languageEnglish (US)
Pages (from-to)9812
Number of pages1
JournalScientific Reports
Volume5
DOIs
StatePublished - 2015
Externally publishedYes

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Independent Living
Brazil
Genome
Population
Single Nucleotide Polymorphism
Phenotype
Epigen

ASJC Scopus subject areas

  • General

Cite this

Lima-Costa, M. F., Rodrigues, L. C., Barreto, M. L., Gouveia, M., Horta, B. L., Mambrini, J., ... Epigen-Brazil group (2015). Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative). Scientific Reports, 5, 9812. https://doi.org/10.1038/srep09812

Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative). / Lima-Costa, M. Fernanda; Rodrigues, Laura C.; Barreto, Maurício L.; Gouveia, Mateus; Horta, Bernardo L.; Mambrini, Juliana; Kehdy, Fernanda S G; Pereira, Alexandre; Rodrigues-Soares, Fernanda; Victora, Cesar G.; Tarazona-Santos, Eduardo; Epigen-Brazil group.

In: Scientific Reports, Vol. 5, 2015, p. 9812.

Research output: Contribution to journalArticle

Lima-Costa, MF, Rodrigues, LC, Barreto, ML, Gouveia, M, Horta, BL, Mambrini, J, Kehdy, FSG, Pereira, A, Rodrigues-Soares, F, Victora, CG, Tarazona-Santos, E & Epigen-Brazil group 2015, 'Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative)', Scientific Reports, vol. 5, pp. 9812. https://doi.org/10.1038/srep09812
Lima-Costa, M. Fernanda ; Rodrigues, Laura C. ; Barreto, Maurício L. ; Gouveia, Mateus ; Horta, Bernardo L. ; Mambrini, Juliana ; Kehdy, Fernanda S G ; Pereira, Alexandre ; Rodrigues-Soares, Fernanda ; Victora, Cesar G. ; Tarazona-Santos, Eduardo ; Epigen-Brazil group. / Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative). In: Scientific Reports. 2015 ; Vol. 5. pp. 9812.
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