Genomic analysis of gene expression relationships in transcriptional regulatory networks

Haiyuan Yu, Nicholas M. Luscombe, Jiang Qian, Mark Gerstein

Research output: Contribution to journalShort surveypeer-review

Abstract

From merging several data sources, we created an extensive map of the transcriptional regulatory network in Saccharomyces cerevisiae, comprising 7419 interactions connecting 180 transcription factors (TFs) with their target genes. We integrated this network with gene-expression data, relating the expression profiles of TFs and target genes. We found that genes targeted by the same TF tend to be co-expressed, with the degree of co-expression increasing if genes share more than one TF. Moreover, shared targets of a TF tend to have similar cellular functions. By contrast, the expression relationships between the TFs and their targets are much more complicated, often exhibiting time-shifted or inverted behavior.

Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalTrends in Genetics
Volume19
Issue number8
DOIs
StatePublished - Aug 1 2003

ASJC Scopus subject areas

  • Genetics

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