Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Gary L Gallia, Ming Zhang, Yi Ning, Michael C. Haffner, Denise Batista, Zev A. Binder, Justin A. Bishop, Christine Hann, Ralph H Hruban, Masaru Ishii, Alison Klein, Douglas D. Reh, Lisa Rooper, Vafi Salmasi, Rafael J Tamargo, Qing Wang, Tara Williamson, Tianna Zhao, Ying Zou, Alan Keith MeekerNishant Agrawal, Bert Vogelstein, Kenneth W Kinzler, Nickolas Papadopoulos, Chetan Bettegowda

Research output: Contribution to journalArticle

Abstract

Olfactory neuroblastoma (ONB) is a rare malignant neoplasm arising in the upper portion of the sinonasal cavity. To better understand the genetic bases for ONB, here we perform whole exome and whole genome sequencing as well as single nucleotide polymorphism array analyses in a series of ONB patient samples. Deletions involving the dystrophin (DMD) locus are found in 12 of 14 (86%) tumors. Interestingly, one of the remaining tumors has a deletion in LAMA2, bringing the number of ONBs with deletions of genes involved in the development of muscular dystrophies to 13 or 93%. This high prevalence implicates an unexpected functional role for genes causing hereditary muscular dystrophies in ONB.

Original languageEnglish (US)
Article number5410
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

Olfactory Esthesioneuroblastoma
deletion
Dystrophin
Genes
genes
Muscular Dystrophies
Tumors
tumors
neoplasms
sequencing
genome
polymorphism
nucleotides
loci
Exome
Polymorphism
Neoplasms
Gene Deletion
Nucleotides
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma. / Gallia, Gary L; Zhang, Ming; Ning, Yi; Haffner, Michael C.; Batista, Denise; Binder, Zev A.; Bishop, Justin A.; Hann, Christine; Hruban, Ralph H; Ishii, Masaru; Klein, Alison; Reh, Douglas D.; Rooper, Lisa; Salmasi, Vafi; Tamargo, Rafael J; Wang, Qing; Williamson, Tara; Zhao, Tianna; Zou, Ying; Meeker, Alan Keith; Agrawal, Nishant; Vogelstein, Bert; Kinzler, Kenneth W; Papadopoulos, Nickolas; Bettegowda, Chetan.

In: Nature Communications, Vol. 9, No. 1, 5410, 01.12.2018.

Research output: Contribution to journalArticle

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AU - Zhang, Ming

AU - Ning, Yi

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AU - Batista, Denise

AU - Binder, Zev A.

AU - Bishop, Justin A.

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