TY - JOUR
T1 - Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24
AU - Schumacher, Johannes
AU - Kaneva, Radka
AU - Jamra, Rami Abou
AU - Diaz, Guillermo Orozco
AU - Ohlraun, Stephanie
AU - Milanova, Vihra
AU - Lee, Young Ae
AU - Rivas, Fabio
AU - Mayoral, Fermin
AU - Fuerst, Robert
AU - Plaquer, Antonia
AU - Windemuth, Christine
AU - Gay, Eudoxia
AU - Sanz, Sebastian
AU - González, Maria José
AU - Gil, Susana
AU - Cabaleiro, Francisco
AU - Del Rio, Francisco
AU - Perez, Fermin
AU - Haro, Jesus
AU - Kostov, Christian
AU - Chorbov, Vesselin
AU - Nikolova-Hill, Amelia
AU - Stoyanova, Vessela
AU - Onchev, George
AU - Kremensky, Ivo
AU - Strauch, Konstantin
AU - Schulze, Thomas G.
AU - Nürnberg, Peter
AU - Gaebel, Wolfgang
AU - Klimke, Ansgar
AU - Auburger, Georg
AU - Wienker, Thomas F.
AU - Kalaydjieva, Luba
AU - Propping, Peter
AU - Cichon, Sven
AU - Jablensky, Assen
AU - Rietschel, Marcella
AU - Nöthen, Markus M.
PY - 2005/12
Y1 - 2005/12
N2 - We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian descent and further fine mapping of the 1p34-p36, 4q28-q31, and 6q15-q24 regions. An additional sample of 56 German families (280 individuals) was included for this fine-mapping step. The highest nonparametric linkage scores obtained in the fine mapping were 5.49 for 4q31 and 4.87 for 6q24 in the Romany families and 3.97 for 1p35-p36 in the Spanish sample. MOD-score (LOD scores maximized over genetic model parameters) analysis provided significant evidence of linkage to 4q31 and at least borderline significance for the 1p and 6q regions. On the basis of these results and previous positive research findings, 4q31 and 6q24 should now be considered confirmed BPAD susceptibility loci, and 1p35-p36 is proposed as a new putative locus that requires confirmation in replication studies.
AB - We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian descent and further fine mapping of the 1p34-p36, 4q28-q31, and 6q15-q24 regions. An additional sample of 56 German families (280 individuals) was included for this fine-mapping step. The highest nonparametric linkage scores obtained in the fine mapping were 5.49 for 4q31 and 4.87 for 6q24 in the Romany families and 3.97 for 1p35-p36 in the Spanish sample. MOD-score (LOD scores maximized over genetic model parameters) analysis provided significant evidence of linkage to 4q31 and at least borderline significance for the 1p and 6q regions. On the basis of these results and previous positive research findings, 4q31 and 6q24 should now be considered confirmed BPAD susceptibility loci, and 1p35-p36 is proposed as a new putative locus that requires confirmation in replication studies.
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U2 - 10.1086/498619
DO - 10.1086/498619
M3 - Article
C2 - 16380920
AN - SCOPUS:28144436565
SN - 0002-9297
VL - 77
SP - 1102
EP - 1111
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 6
ER -