Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24

Johannes Schumacher, Radka Kaneva, Rami Abou Jamra, Guillermo Orozco Diaz, Stephanie Ohlraun, Vihra Milanova, Young Ae Lee, Fabio Rivas, Fermin Mayoral, Robert Fuerst, Antonia Plaquer, Christine Windemuth, Eudoxia Gay, Sebastian Sanz, Maria José González, Susana Gil, Francisco Cabaleiro, Francisco Del Rio, Fermin Perez, Jesus HaroChristian Kostov, Vesselin Chorbov, Amelia Nikolova-Hill, Vessela Stoyanova, George Onchev, Ivo Kremensky, Konstantin Strauch, Thomas G. Schulze, Peter Nürnberg, Wolfgang Gaebel, Ansgar Klimke, Georg Auburger, Thomas F. Wienker, Luba Kalaydjieva, Peter Propping, Sven Cichon, Assen Jablensky, Marcella Rietschel, Markus M. Nöthen

Research output: Contribution to journalArticlepeer-review

Abstract

We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian descent and further fine mapping of the 1p34-p36, 4q28-q31, and 6q15-q24 regions. An additional sample of 56 German families (280 individuals) was included for this fine-mapping step. The highest nonparametric linkage scores obtained in the fine mapping were 5.49 for 4q31 and 4.87 for 6q24 in the Romany families and 3.97 for 1p35-p36 in the Spanish sample. MOD-score (LOD scores maximized over genetic model parameters) analysis provided significant evidence of linkage to 4q31 and at least borderline significance for the 1p and 6q regions. On the basis of these results and previous positive research findings, 4q31 and 6q24 should now be considered confirmed BPAD susceptibility loci, and 1p35-p36 is proposed as a new putative locus that requires confirmation in replication studies.

Original languageEnglish (US)
Pages (from-to)1102-1111
Number of pages10
JournalAmerican Journal of Human Genetics
Volume77
Issue number6
DOIs
StatePublished - Dec 2005
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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