Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome

Emily S. Wan, Weiliang Qiu, Jarrett Morrow, Terri L Beaty, Jacqueline Hetmanski, Barry J. Make, David A. Lomas, Edwin K. Silverman, Dawn L. Demeo

Research output: Contribution to journalArticle

Abstract

Klinefelter syndrome (KS) (47 XXY) is a common sex-chromosome aneuploidy with an estimated prevalence of one in every 660 male births. Investigations into the associations between DNA methylation and the highly variable clinical manifestations of KS have largely focused on the supernumerary X chromosome; systematic investigations of the epigenome have been limited. We obtained genome-wide DNA methylation data from peripheral blood using the Illumina HumanMethylation450K platform in 5 KS (47 XXY) versus 102 male (46 XY) and 113 female (46 XX) control subjects participating in the COPDGene Study. Empirical Bayes-mediated models were used to test for differential methylation by KS status. CpG sites with a false-discovery rate

Original languageEnglish (US)
Pages (from-to)377-386
Number of pages10
JournalMolecular Reproduction and Development
Volume82
Issue number5
DOIs
StatePublished - May 1 2015

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Klinefelter Syndrome
Methylation
Genome
DNA Methylation
Sex Chromosomes
X Chromosome
Aneuploidy
Parturition

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome. / Wan, Emily S.; Qiu, Weiliang; Morrow, Jarrett; Beaty, Terri L; Hetmanski, Jacqueline; Make, Barry J.; Lomas, David A.; Silverman, Edwin K.; Demeo, Dawn L.

In: Molecular Reproduction and Development, Vol. 82, No. 5, 01.05.2015, p. 377-386.

Research output: Contribution to journalArticle

Wan, ES, Qiu, W, Morrow, J, Beaty, TL, Hetmanski, J, Make, BJ, Lomas, DA, Silverman, EK & Demeo, DL 2015, 'Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome', Molecular Reproduction and Development, vol. 82, no. 5, pp. 377-386. https://doi.org/10.1002/mrd.22483
Wan, Emily S. ; Qiu, Weiliang ; Morrow, Jarrett ; Beaty, Terri L ; Hetmanski, Jacqueline ; Make, Barry J. ; Lomas, David A. ; Silverman, Edwin K. ; Demeo, Dawn L. / Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome. In: Molecular Reproduction and Development. 2015 ; Vol. 82, No. 5. pp. 377-386.
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