Genome-wide sequencing to identify the cause of hereditary cancer syndromes: With examples from familial pancreatic cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

Advances in our understanding of the human genome and next-generation technologies have facilitated the use of genome-wide sequencing to decipher the genetic basis of Mendelian disease and hereditary cancer syndromes. However, the application of genome-wide sequencing in hereditary cancer syndromes has had mixed success, in part, due to complex nature of the underlying genetic architecture. In this review we discuss the use of genome-wide sequencing in both Mendelian diseases and hereditary cancer syndromes, highlighting the potential and challenges of this approach using familial pancreatic cancer as an example.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalCancer Letters
Volume340
Issue number2
DOIs
StatePublished - Nov 1 2013

Keywords

  • Cancer predisposition genes
  • Genome sequencing
  • Hereditary cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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