Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: The Family Investigation of Nephropathy and Diabetes (FIND)

Sudha K. Iyengar; Hanna E. Abboud; Katrina A.B. Goddard; Mohammed F. Saad; Sharon G. Adler; Nedal H. Arar; Donald W. Bowden; Ravi Duggirala; Robert C. Elston; Robert L. Hanson; Eli Ipp; W. H.Linda Kao; Paul L. Kimmel; Michael J. Klag; William C. Knowler; Lucy A. Meoni; Robert G. Nelson; Susanne B. Nicholas; Madeleine V. Pahl; Rulan S. Parekh; Shannon R.E. Quade; Stephen S. Rich; Jerome I. Rotter; Marina Scavini; Jeffrey R. Schelling; John R. Sedor; Ashwini R. Sehgal; Vallabh O. Shah; Michael W. Smith; Kent D. Taylor; Cheryl A. Winkler; Philip G. Zager; Barry I. Freedman

doi:10.2337/db06-1154

Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: The Family Investigation of Nephropathy and Diabetes (FIND)

Sudha K. Iyengar, Hanna E. Abboud, Katrina A.B. Goddard, Mohammed F. Saad, Sharon G. Adler, Nedal H. Arar, Donald W. Bowden, Ravi Duggirala, Robert C. Elston, Robert L. Hanson, Eli Ipp, W. H.Linda Kao, Paul L. Kimmel, Michael J. Klag, William C. Knowler, Lucy A. Meoni, Robert G. Nelson, Susanne B. Nicholas, Madeleine V. Pahl, Rulan S. ParekhShannon R.E. Quade, Stephen S. Rich, Jerome I. Rotter, Marina Scavini, Jeffrey R. Schelling, John R. Sedor, Ashwini R. Sehgal, Vallabh O. Shah, Michael W. Smith, Kent D. Taylor, Cheryl A. Winkler, Philip G. Zager, Barry I. Freedman

School of Medicine

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117 Scopus citations

Abstract

The Family Investigation of Nephropathy and Diabetes (FIND) was initiated to map genes underlying susceptibility to diabetic nephropathy. A total of 11 centers participated under a single collection protocol to recruit large numbers of diabetic sibling pairs concordant and discordant for diabetic nephropathy. We report the findings from the first-phase genetic analyses in 1,227 participants from 378 pedigrees of European-American, African-American, Mexican-American, and American Indian descent recruited from eight centers. Model-free linkage analyses, using a dichotomous definition for diabetic nephropathy in 397 sibling pairs, as well as the quantitative trait urinary albumin-to-creatinine ratio (ACR), were performed using the Haseman-Elston linkage test on 404 microsatellite markers. The strongest evidence of linkage to the diabetic nephropathy trait was on chromosomes 7q21.3, 10p15.3, 14q23.1, and 18q22.3. In ACR (883 diabetic sibling pairs), the strongest linkage signals were on chromosomes 2q14.1, 7q21.1, and 15q26.3. These results confirm regions of linkage to diabetic nephropathy on chromosomes 7q, 10p, and 18q from prior reports, making it important that genes underlying these peaks be evaluated for their contribution to nephropathy susceptibility. Large family collections consisting of multiple members with diabetes and advanced nephropathy are likely to accelerate the identification of genes causing diabetic nephropathy, a life-threatening complication of diabetes.

Original language	English (US)
Pages (from-to)	1577-1585
Number of pages	9
Journal	Diabetes
Volume	56
Issue number	6
DOIs	https://doi.org/10.2337/db06-1154
State	Published - Jun 2007

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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Iyengar, S. K., Abboud, H. E., Goddard, K. A. B., Saad, M. F., Adler, S. G., Arar, N. H., Bowden, D. W., Duggirala, R., Elston, R. C., Hanson, R. L., Ipp, E., Kao, W. H. L., Kimmel, P. L., Klag, M. J., Knowler, W. C., Meoni, L. A., Nelson, R. G., Nicholas, S. B., Pahl, M. V., ... Freedman, B. I. (2007). Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: The Family Investigation of Nephropathy and Diabetes (FIND). Diabetes, 56(6), 1577-1585. https://doi.org/10.2337/db06-1154

Iyengar, SK, Abboud, HE, Goddard, KAB, Saad, MF, Adler, SG, Arar, NH, Bowden, DW, Duggirala, R, Elston, RC, Hanson, RL, Ipp, E, Kao, WHL, Kimmel, PL, Klag, MJ, Knowler, WC, Meoni, LA, Nelson, RG, Nicholas, SB, Pahl, MV, Parekh, RS, Quade, SRE, Rich, SS, Rotter, JI, Scavini, M, Schelling, JR, Sedor, JR, Sehgal, AR, Shah, VO, Smith, MW, Taylor, KD, Winkler, CA, Zager, PG & Freedman, BI 2007, 'Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: The Family Investigation of Nephropathy and Diabetes (FIND)', Diabetes, vol. 56, no. 6, pp. 1577-1585. https://doi.org/10.2337/db06-1154

@article{fc81d95039cb4d6cb06561fe023c1a16,

title = "Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: The Family Investigation of Nephropathy and Diabetes (FIND)",

abstract = "The Family Investigation of Nephropathy and Diabetes (FIND) was initiated to map genes underlying susceptibility to diabetic nephropathy. A total of 11 centers participated under a single collection protocol to recruit large numbers of diabetic sibling pairs concordant and discordant for diabetic nephropathy. We report the findings from the first-phase genetic analyses in 1,227 participants from 378 pedigrees of European-American, African-American, Mexican-American, and American Indian descent recruited from eight centers. Model-free linkage analyses, using a dichotomous definition for diabetic nephropathy in 397 sibling pairs, as well as the quantitative trait urinary albumin-to-creatinine ratio (ACR), were performed using the Haseman-Elston linkage test on 404 microsatellite markers. The strongest evidence of linkage to the diabetic nephropathy trait was on chromosomes 7q21.3, 10p15.3, 14q23.1, and 18q22.3. In ACR (883 diabetic sibling pairs), the strongest linkage signals were on chromosomes 2q14.1, 7q21.1, and 15q26.3. These results confirm regions of linkage to diabetic nephropathy on chromosomes 7q, 10p, and 18q from prior reports, making it important that genes underlying these peaks be evaluated for their contribution to nephropathy susceptibility. Large family collections consisting of multiple members with diabetes and advanced nephropathy are likely to accelerate the identification of genes causing diabetic nephropathy, a life-threatening complication of diabetes.",

author = "Iyengar, {Sudha K.} and Abboud, {Hanna E.} and Goddard, {Katrina A.B.} and Saad, {Mohammed F.} and Adler, {Sharon G.} and Arar, {Nedal H.} and Bowden, {Donald W.} and Ravi Duggirala and Elston, {Robert C.} and Hanson, {Robert L.} and Eli Ipp and Kao, {W. H.Linda} and Kimmel, {Paul L.} and Klag, {Michael J.} and Knowler, {William C.} and Meoni, {Lucy A.} and Nelson, {Robert G.} and Nicholas, {Susanne B.} and Pahl, {Madeleine V.} and Parekh, {Rulan S.} and Quade, {Shannon R.E.} and Rich, {Stephen S.} and Rotter, {Jerome I.} and Marina Scavini and Schelling, {Jeffrey R.} and Sedor, {John R.} and Sehgal, {Ashwini R.} and Shah, {Vallabh O.} and Smith, {Michael W.} and Taylor, {Kent D.} and Winkler, {Cheryl A.} and Zager, {Philip G.} and Freedman, {Barry I.}",

year = "2007",

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doi = "10.2337/db06-1154",

language = "English (US)",

volume = "56",

pages = "1577--1585",

journal = "Diabetes",

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T1 - Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations

T2 - The Family Investigation of Nephropathy and Diabetes (FIND)

AU - Iyengar, Sudha K.

AU - Abboud, Hanna E.

AU - Goddard, Katrina A.B.

AU - Saad, Mohammed F.

AU - Adler, Sharon G.

AU - Arar, Nedal H.

AU - Bowden, Donald W.

AU - Duggirala, Ravi

AU - Elston, Robert C.

AU - Hanson, Robert L.

AU - Ipp, Eli

AU - Kao, W. H.Linda

AU - Kimmel, Paul L.

AU - Klag, Michael J.

AU - Knowler, William C.

AU - Meoni, Lucy A.

AU - Nelson, Robert G.

AU - Nicholas, Susanne B.

AU - Pahl, Madeleine V.

AU - Parekh, Rulan S.

AU - Quade, Shannon R.E.

AU - Rich, Stephen S.

AU - Rotter, Jerome I.

AU - Scavini, Marina

AU - Schelling, Jeffrey R.

AU - Sedor, John R.

AU - Sehgal, Ashwini R.

AU - Shah, Vallabh O.

AU - Smith, Michael W.

AU - Taylor, Kent D.

AU - Winkler, Cheryl A.

AU - Zager, Philip G.

AU - Freedman, Barry I.

PY - 2007/6

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Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: The Family Investigation of Nephropathy and Diabetes (FIND)

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