Genome-Wide Scan of Swedish Families with Hereditary Prostate Cancer: Suggestive Evidence of Linkage at 5q11.2 and 19p13.3

Fredrik Wiklund, Elizabeth M. Gillanders, Julie A. Albertus, Anders Bergh, Jan Erik Damber, Monica Emanuelsson, Diana L. Freas-Lutz, Derek E. Gildea, Ingela Göransson, Mary Pat S. Jones, Björn Anders Jonsson, Fredrik Lindmark, Carol J. Markey, Erica L. Riedesel, Elisabeth Stenman, Jeffry M. Trent, Henrik Grönberg

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Prostate cancer (CaP) is a common disorder with multiple genetic and environmental factors contributing to the disease. CaP susceptibility loci can be identified through genome-wide scans of high-risk families. METHODS. Allele sharing at 405 markers, distributed across the genome, among 50 families with hereditary prostate cancer, ascertained throughout Sweden, was evaluated through linkage analyses. Genotype data were analyzed utilizing multipoint parametric and non-parametric methods. RESULTS. Two regions provided suggestive evidence for linkage: 19p13.3 (marker D19S209, LOD = 2.91, P = 0.0001) and 5q11.2 (marker D5S407, LOD = 2.24, P = 0.0007). Additional regions with moderate evidence for linkage in the complete set of families, or stratified subsets, were observed on chromosome 1, 4, 6, 7, 8, and X. CONCLUSIONS. Our results provide strong confirmatory evidence of linkage at 19q13.3 and 5q11.2. The lack of confirmation of linkage at several loci identified in other genome-wide scans emphasizes the need to combine linkage data between research groups.

Original languageEnglish (US)
Pages (from-to)290-297
Number of pages8
JournalProstate
Volume57
Issue number4
DOIs
StatePublished - Dec 1 2003

Keywords

  • Genome-wide scan
  • Hereditary prostate cancer
  • Linkage analysis

ASJC Scopus subject areas

  • Oncology
  • Urology

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    Wiklund, F., Gillanders, E. M., Albertus, J. A., Bergh, A., Damber, J. E., Emanuelsson, M., Freas-Lutz, D. L., Gildea, D. E., Göransson, I., Jones, M. P. S., Jonsson, B. A., Lindmark, F., Markey, C. J., Riedesel, E. L., Stenman, E., Trent, J. M., & Grönberg, H. (2003). Genome-Wide Scan of Swedish Families with Hereditary Prostate Cancer: Suggestive Evidence of Linkage at 5q11.2 and 19p13.3. Prostate, 57(4), 290-297. https://doi.org/10.1002/pros.10303