Genome-Wide Scan for Prostate Cancer Susceptibility Genes Using Families from the University of Michigan Prostate Cancer Genetics Project Finds Evidence for Linkage on Chromosome 17 Near BRCA1

Ethan M. Lange, Elizabeth M. Gillanders, Cralen C. Davis, W. Mark Brown, Joel K. Campbell, MaryPat Jones, Derek Gildea, Erica Riedesel, Julie Albertus, Diana Freas-Lutz, Carol Markey, Veda Giri, Jennifer Beebe Dimmer, James E. Montie, Jeffrey M. Trent, Kathleen A. Cooney

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Previous linkage studies have suggested prostate cancer susceptibility genes located on chromosomes 1, 20, and X. Several putative prostate cancer candidate genes have also been identified including RNASEL, MSR1, and ELAC2. Presently, these linkage regions and candidate genes appear to explain only a small proportion of hereditary prostate cancer cases suggesting the need for additional whole genome analyses. METHODS. A genome-wide mode-of-inheritance-free linkage scan, using 405 genetic markers, was conducted on 175 pedigrees, the majority containing three or more affected individuals diagnosed with prostate cancer. Stratified linkage analyses were performed based on previously established criteria. RESULTS. Results based on the entire set of 175 pedigrees showed strong suggestive evidence for linkage on chromosome 17q (LOD = 2.36), with strongest evidence coming from the subset of pedigrees with four or more affected individuals (LOD=3.27). Race specific analyses revealed strong suggestive evidence for linkage in our African-American pedigrees on chromosome 22q (LOD = 2.35). CONCLUSIONS. Genome-wide analysis of a large set of prostate cancer families indicates new areas of the genome that may harbor prostate cancer susceptibility genes. Specifically, our linkage results suggest that there is a prostate cancer susceptibility gene on chromosome 17 that is independent of ELAC2. Further research including combined analyses of independent genome-wide scan data may clarify the most important regions for future investigation.

Original languageEnglish (US)
Pages (from-to)326-334
Number of pages9
JournalProstate
Volume57
Issue number4
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

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Chromosomes, Human, Pair 17
Neoplasm Genes
Prostatic Neoplasms
Genome
Pedigree
Chromosomes
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 1
Genetic Markers
African Americans
Research
Genes

Keywords

  • BRCA1
  • Linkage analysis
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Genome-Wide Scan for Prostate Cancer Susceptibility Genes Using Families from the University of Michigan Prostate Cancer Genetics Project Finds Evidence for Linkage on Chromosome 17 Near BRCA1. / Lange, Ethan M.; Gillanders, Elizabeth M.; Davis, Cralen C.; Brown, W. Mark; Campbell, Joel K.; Jones, MaryPat; Gildea, Derek; Riedesel, Erica; Albertus, Julie; Freas-Lutz, Diana; Markey, Carol; Giri, Veda; Dimmer, Jennifer Beebe; Montie, James E.; Trent, Jeffrey M.; Cooney, Kathleen A.

In: Prostate, Vol. 57, No. 4, 01.12.2003, p. 326-334.

Research output: Contribution to journalArticle

Lange, EM, Gillanders, EM, Davis, CC, Brown, WM, Campbell, JK, Jones, M, Gildea, D, Riedesel, E, Albertus, J, Freas-Lutz, D, Markey, C, Giri, V, Dimmer, JB, Montie, JE, Trent, JM & Cooney, KA 2003, 'Genome-Wide Scan for Prostate Cancer Susceptibility Genes Using Families from the University of Michigan Prostate Cancer Genetics Project Finds Evidence for Linkage on Chromosome 17 Near BRCA1', Prostate, vol. 57, no. 4, pp. 326-334. https://doi.org/10.1002/pros.10307
Lange, Ethan M. ; Gillanders, Elizabeth M. ; Davis, Cralen C. ; Brown, W. Mark ; Campbell, Joel K. ; Jones, MaryPat ; Gildea, Derek ; Riedesel, Erica ; Albertus, Julie ; Freas-Lutz, Diana ; Markey, Carol ; Giri, Veda ; Dimmer, Jennifer Beebe ; Montie, James E. ; Trent, Jeffrey M. ; Cooney, Kathleen A. / Genome-Wide Scan for Prostate Cancer Susceptibility Genes Using Families from the University of Michigan Prostate Cancer Genetics Project Finds Evidence for Linkage on Chromosome 17 Near BRCA1. In: Prostate. 2003 ; Vol. 57, No. 4. pp. 326-334.
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abstract = "BACKGROUND. Previous linkage studies have suggested prostate cancer susceptibility genes located on chromosomes 1, 20, and X. Several putative prostate cancer candidate genes have also been identified including RNASEL, MSR1, and ELAC2. Presently, these linkage regions and candidate genes appear to explain only a small proportion of hereditary prostate cancer cases suggesting the need for additional whole genome analyses. METHODS. A genome-wide mode-of-inheritance-free linkage scan, using 405 genetic markers, was conducted on 175 pedigrees, the majority containing three or more affected individuals diagnosed with prostate cancer. Stratified linkage analyses were performed based on previously established criteria. RESULTS. Results based on the entire set of 175 pedigrees showed strong suggestive evidence for linkage on chromosome 17q (LOD = 2.36), with strongest evidence coming from the subset of pedigrees with four or more affected individuals (LOD=3.27). Race specific analyses revealed strong suggestive evidence for linkage in our African-American pedigrees on chromosome 22q (LOD = 2.35). CONCLUSIONS. Genome-wide analysis of a large set of prostate cancer families indicates new areas of the genome that may harbor prostate cancer susceptibility genes. Specifically, our linkage results suggest that there is a prostate cancer susceptibility gene on chromosome 17 that is independent of ELAC2. Further research including combined analyses of independent genome-wide scan data may clarify the most important regions for future investigation.",
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T1 - Genome-Wide Scan for Prostate Cancer Susceptibility Genes Using Families from the University of Michigan Prostate Cancer Genetics Project Finds Evidence for Linkage on Chromosome 17 Near BRCA1

AU - Lange, Ethan M.

AU - Gillanders, Elizabeth M.

AU - Davis, Cralen C.

AU - Brown, W. Mark

AU - Campbell, Joel K.

AU - Jones, MaryPat

AU - Gildea, Derek

AU - Riedesel, Erica

AU - Albertus, Julie

AU - Freas-Lutz, Diana

AU - Markey, Carol

AU - Giri, Veda

AU - Dimmer, Jennifer Beebe

AU - Montie, James E.

AU - Trent, Jeffrey M.

AU - Cooney, Kathleen A.

PY - 2003/12/1

Y1 - 2003/12/1

N2 - BACKGROUND. Previous linkage studies have suggested prostate cancer susceptibility genes located on chromosomes 1, 20, and X. Several putative prostate cancer candidate genes have also been identified including RNASEL, MSR1, and ELAC2. Presently, these linkage regions and candidate genes appear to explain only a small proportion of hereditary prostate cancer cases suggesting the need for additional whole genome analyses. METHODS. A genome-wide mode-of-inheritance-free linkage scan, using 405 genetic markers, was conducted on 175 pedigrees, the majority containing three or more affected individuals diagnosed with prostate cancer. Stratified linkage analyses were performed based on previously established criteria. RESULTS. Results based on the entire set of 175 pedigrees showed strong suggestive evidence for linkage on chromosome 17q (LOD = 2.36), with strongest evidence coming from the subset of pedigrees with four or more affected individuals (LOD=3.27). Race specific analyses revealed strong suggestive evidence for linkage in our African-American pedigrees on chromosome 22q (LOD = 2.35). CONCLUSIONS. Genome-wide analysis of a large set of prostate cancer families indicates new areas of the genome that may harbor prostate cancer susceptibility genes. Specifically, our linkage results suggest that there is a prostate cancer susceptibility gene on chromosome 17 that is independent of ELAC2. Further research including combined analyses of independent genome-wide scan data may clarify the most important regions for future investigation.

AB - BACKGROUND. Previous linkage studies have suggested prostate cancer susceptibility genes located on chromosomes 1, 20, and X. Several putative prostate cancer candidate genes have also been identified including RNASEL, MSR1, and ELAC2. Presently, these linkage regions and candidate genes appear to explain only a small proportion of hereditary prostate cancer cases suggesting the need for additional whole genome analyses. METHODS. A genome-wide mode-of-inheritance-free linkage scan, using 405 genetic markers, was conducted on 175 pedigrees, the majority containing three or more affected individuals diagnosed with prostate cancer. Stratified linkage analyses were performed based on previously established criteria. RESULTS. Results based on the entire set of 175 pedigrees showed strong suggestive evidence for linkage on chromosome 17q (LOD = 2.36), with strongest evidence coming from the subset of pedigrees with four or more affected individuals (LOD=3.27). Race specific analyses revealed strong suggestive evidence for linkage in our African-American pedigrees on chromosome 22q (LOD = 2.35). CONCLUSIONS. Genome-wide analysis of a large set of prostate cancer families indicates new areas of the genome that may harbor prostate cancer susceptibility genes. Specifically, our linkage results suggest that there is a prostate cancer susceptibility gene on chromosome 17 that is independent of ELAC2. Further research including combined analyses of independent genome-wide scan data may clarify the most important regions for future investigation.

KW - BRCA1

KW - Linkage analysis

KW - Prostate cancer

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