Genome-Wide Scan for Linkage in Finnish Hereditary Prostate Cancer (HPC) Families Identifies Novel Susceptibility Loci at 11q14 and 3p25-26

Johanna Schleutker, Agnes B. Baffoe-Bonnie, Elizabeth Gillanders, Tommi Kainu, Mary Pat Jones, Diana Freas-Lutz, Carol Markey, Derek Gildea, Erica Riedesel, Julie Albertus, Kenneth D. Gibbs, Mika Matikainen, Pasi A. Koivisto, Teuvo Tammela, Joan E. Bailey-Wilson, Jeffrey M. Trent, Olli P. Kallioniemi

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND. In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families. METHODS. Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown. RESULTS. The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (0 = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25-26, with a two-point LOD score of 2.57 (0 = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02). CONCLUSIONS. The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.

Original languageEnglish (US)
Pages (from-to)280-289
Number of pages10
JournalProstate
Volume57
Issue number4
DOIs
StatePublished - Dec 1 2003

Keywords

  • Cancer predisposition
  • Familiar cancer
  • Genetic susceptibility
  • Homogeneous population

ASJC Scopus subject areas

  • Oncology
  • Urology

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