Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption

Marilyn C. Cornelis; Keri L. Monda; Kai Yu; Nina Paynter; Elizabeth M. Azzato; Siiri N. Bennett; Sonja I. Berndt; Eric Boerwinkle; Stephen Chanock; Nilanjan Chatterjee; David Couper; Gary Curhan; Gerardo Heiss; Frank B. Hu; David J. Hunter; Kevin Jacobs; Majken K. Jensen; Peter Kraft; Maria Teresa Landi; Jennifer A. Nettleton; Mark P. Purdue; Preetha Rajaraman; Eric B. Rimm; Lynda M. Rose; Nathaniel Rothman; Debra Silverman; Rachael Stolzenberg-Solomon; Amy Subar; Meredith Yeager; Daniel I. Chasman; Rob M. van Dam; Neil E. Caporaso

doi:10.1371/journal.pgen.1002033

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption

Marilyn C. Cornelis, Keri L. Monda, Kai Yu, Nina Paynter, Elizabeth M. Azzato, Siiri N. Bennett, Sonja I. Berndt, Eric Boerwinkle, Stephen Chanock, Nilanjan Chatterjee, David Couper, Gary Curhan, Gerardo Heiss, Frank B. Hu, David J. Hunter, Kevin Jacobs, Majken K. Jensen, Peter Kraft, Maria Teresa Landi, Jennifer A. NettletonMark P. Purdue, Preetha Rajaraman, Eric B. Rimm, Lynda M. Rose, Nathaniel Rothman, Debra Silverman, Rachael Stolzenberg-Solomon, Amy Subar, Meredith Yeager, Daniel I. Chasman, Rob M. van Dam, Neil E. Caporaso

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Abstract

We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4×10^-19), near AHR, and 15q24 (P = 5.2×10^-14), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.

Original language	English (US)
Article number	e1002033
Journal	PLoS genetics
Volume	7
Issue number	4
DOIs	https://doi.org/10.1371/journal.pgen.1002033
State	Published - Apr 2011
Externally published	Yes

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Genetics(clinical)
Cancer Research

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Cornelis, M. C., Monda, K. L., Yu, K., Paynter, N., Azzato, E. M., Bennett, S. N., Berndt, S. I., Boerwinkle, E., Chanock, S., Chatterjee, N., Couper, D., Curhan, G., Heiss, G., Hu, F. B., Hunter, D. J., Jacobs, K., Jensen, M. K., Kraft, P., Landi, M. T., ... Caporaso, N. E. (2011). Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS genetics, 7(4), Article e1002033. https://doi.org/10.1371/journal.pgen.1002033

Cornelis, MC, Monda, KL, Yu, K, Paynter, N, Azzato, EM, Bennett, SN, Berndt, SI, Boerwinkle, E, Chanock, S, Chatterjee, N, Couper, D, Curhan, G, Heiss, G, Hu, FB, Hunter, DJ, Jacobs, K, Jensen, MK, Kraft, P, Landi, MT, Nettleton, JA, Purdue, MP, Rajaraman, P, Rimm, EB, Rose, LM, Rothman, N, Silverman, D, Stolzenberg-Solomon, R, Subar, A, Yeager, M, Chasman, DI, van Dam, RM & Caporaso, NE 2011, 'Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption', PLoS genetics, vol. 7, no. 4, e1002033. https://doi.org/10.1371/journal.pgen.1002033

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abstract = "We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4×10-19), near AHR, and 15q24 (P = 5.2×10-14), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.",

author = "Cornelis, {Marilyn C.} and Monda, {Keri L.} and Kai Yu and Nina Paynter and Azzato, {Elizabeth M.} and Bennett, {Siiri N.} and Berndt, {Sonja I.} and Eric Boerwinkle and Stephen Chanock and Nilanjan Chatterjee and David Couper and Gary Curhan and Gerardo Heiss and Hu, {Frank B.} and Hunter, {David J.} and Kevin Jacobs and Jensen, {Majken K.} and Peter Kraft and Landi, {Maria Teresa} and Nettleton, {Jennifer A.} and Purdue, {Mark P.} and Preetha Rajaraman and Rimm, {Eric B.} and Rose, {Lynda M.} and Nathaniel Rothman and Debra Silverman and Rachael Stolzenberg-Solomon and Amy Subar and Meredith Yeager and Chasman, {Daniel I.} and {van Dam}, {Rob M.} and Caporaso, {Neil E.}",

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AU - Yu, Kai

AU - Paynter, Nina

AU - Azzato, Elizabeth M.

AU - Bennett, Siiri N.

AU - Berndt, Sonja I.

AU - Boerwinkle, Eric

AU - Chanock, Stephen

AU - Chatterjee, Nilanjan

AU - Couper, David

AU - Curhan, Gary

AU - Heiss, Gerardo

AU - Hu, Frank B.

AU - Hunter, David J.

AU - Jacobs, Kevin

AU - Jensen, Majken K.

AU - Kraft, Peter

AU - Landi, Maria Teresa

AU - Nettleton, Jennifer A.

AU - Purdue, Mark P.

AU - Rajaraman, Preetha

AU - Rimm, Eric B.

AU - Rose, Lynda M.

AU - Rothman, Nathaniel

AU - Silverman, Debra

AU - Stolzenberg-Solomon, Rachael

AU - Subar, Amy

AU - Yeager, Meredith

AU - Chasman, Daniel I.

AU - van Dam, Rob M.

AU - Caporaso, Neil E.

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Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption

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