Genome-wide association study of prostate cancer-specific survival

Robert Szulkin; Robert Karlsson; Thomas Whitington; Markus Aly; Henrik Gronberg; Rosalind A. Eeles; Douglas F. Easton; Zsofia Kote-Jarai; Ali Amin Al Olama; Sara Benlloch; Kenneth Muir; Graham G. Giles; Melissa C. Southey; Liesel M. Fitzgerald; Brian E. Henderson; Fredrick R. Schumacher; Christopher A. Haiman; Csilla Sipeky; Teuvol J. Tammela; Børge G. Nordestgaard; Timothy J. Key; Ruth C. Travis; David E. Neal; Jenny L. Donovan; Freddie C. Hamdy; Paul D.P. Pharoah; Nora Pashayan; Kay Tee Khaw; Janet L. Stanford; Stephen N. Thibodeau; Shannon K. McDonnell; Daniel J. Schaid; Christiane Maier; Walther Vogel; Manuel Luedeke; Kathleen Herkommer; Adam S. Kibel; Cezary Cybulski; Jan Lubinski; Wojciech Kluzniak; Lisa Cannon-Albright; Hermann Brenner; Volker Herrmann; Bernd Holleczek; Jong Y. Park; Thomas A. Sellers; Hui Yi Lim; Chavdar Slavov; Radka P. Kaneva; Vanio I. Mitev; Amanda Spurdle; Manuel R. Teixeira; Paula Paulo; Sofia Maia; Hardev Pandha; Agnieszka Michael; Andrzej Kierzek; Jyotsna Batra; Judith A. Clements; Demetrius Albanes; Gerald L. Andriole; Sonja I. Berndt; Stephen Chanock; Susan M. Gapstur; Edward L. Giovannucci; David J. Hunter; Peter Kraft; Loic Le Marchand; Jing Ma; Alison M. Mondul; Kathryn L. Penney; Meir J. Stampfer; Victoria L. Stevens; Stephanie J. Weinstein; Antonia Trichopoulou; Bas H. Bueno-De-mesquita; Anne Tjønneland; David G. Cox; Lovise Maehle; Johanna Schleutker; Sara Lindstrom; Fredrik Wiklund

doi:10.1158/1055-9965.EPI-15-0543

Genome-wide association study of prostate cancer-specific survival

Robert Szulkin, Robert Karlsson, Thomas Whitington, Markus Aly, Henrik Gronberg, Rosalind A. Eeles, Douglas F. Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G. Giles, Melissa C. Southey, Liesel M. Fitzgerald, Brian E. Henderson, Fredrick R. Schumacher, Christopher A. Haiman, Csilla Sipeky, Teuvol J. Tammela, Børge G. NordestgaardTimothy J. Key, Ruth C. Travis, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Paul D.P. Pharoah, Nora Pashayan, Kay Tee Khaw, Janet L. Stanford, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Christiane Maier, Walther Vogel, Manuel Luedeke, Kathleen Herkommer, Adam S. Kibel, Cezary Cybulski, Jan Lubinski, Wojciech Kluzniak, Lisa Cannon-Albright, Hermann Brenner, Volker Herrmann, Bernd Holleczek, Jong Y. Park, Thomas A. Sellers, Hui Yi Lim, Chavdar Slavov, Radka P. Kaneva, Vanio I. Mitev, Amanda Spurdle, Manuel R. Teixeira, Paula Paulo, Sofia Maia, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, Jyotsna Batra, Judith A. Clements, Demetrius Albanes, Gerald L. Andriole, Sonja I. Berndt, Stephen Chanock, Susan M. Gapstur, Edward L. Giovannucci, David J. Hunter, Peter Kraft, Loic Le Marchand, Jing Ma, Alison M. Mondul, Kathryn L. Penney, Meir J. Stampfer, Victoria L. Stevens, Stephanie J. Weinstein, Antonia Trichopoulou, Bas H. Bueno-De-mesquita, Anne Tjønneland, David G. Cox, Lovise Maehle, Johanna Schleutker, Sara Lindstrom, Fredrik Wiklund

School of Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

Original language	English (US)
Pages (from-to)	1796-1800
Number of pages	5
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	24
Issue number	11
DOIs	https://doi.org/10.1158/1055-9965.EPI-15-0543
State	Published - Nov 2015

ASJC Scopus subject areas

General Medicine

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10.1158/1055-9965.EPI-15-0543

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Szulkin, R., Karlsson, R., Whitington, T., Aly, M., Gronberg, H., Eeles, R. A., Easton, D. F., Kote-Jarai, Z., Al Olama, A. A., Benlloch, S., Muir, K., Giles, G. G., Southey, M. C., Fitzgerald, L. M., Henderson, B. E., Schumacher, F. R., Haiman, C. A., Sipeky, C., Tammela, T. J., ... Wiklund, F. (2015). Genome-wide association study of prostate cancer-specific survival. Cancer Epidemiology Biomarkers and Prevention, 24(11), 1796-1800. https://doi.org/10.1158/1055-9965.EPI-15-0543

Szulkin, R, Karlsson, R, Whitington, T, Aly, M, Gronberg, H, Eeles, RA, Easton, DF, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, Fitzgerald, LM, Henderson, BE, Schumacher, FR, Haiman, CA, Sipeky, C, Tammela, TJ, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, PDP, Pashayan, N, Khaw, KT, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Lubinski, J, Kluzniak, W, Cannon-Albright, L, Brenner, H, Herrmann, V, Holleczek, B, Park, JY, Sellers, TA, Lim, HY, Slavov, C, Kaneva, RP, Mitev, VI, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Pandha, H, Michael, A, Kierzek, A, Batra, J, Clements, JA, Albanes, D, Andriole, GL, Berndt, SI, Chanock, S, Gapstur, SM, Giovannucci, EL, Hunter, DJ, Kraft, P, Le Marchand, L, Ma, J, Mondul, AM, Penney, KL, Stampfer, MJ, Stevens, VL, Weinstein, SJ, Trichopoulou, A, Bueno-De-mesquita, BH, Tjønneland, A, Cox, DG, Maehle, L, Schleutker, J, Lindstrom, S & Wiklund, F 2015, 'Genome-wide association study of prostate cancer-specific survival', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 11, pp. 1796-1800. https://doi.org/10.1158/1055-9965.EPI-15-0543

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title = "Genome-wide association study of prostate cancer-specific survival",

abstract = "Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.",

author = "Robert Szulkin and Robert Karlsson and Thomas Whitington and Markus Aly and Henrik Gronberg and Eeles, {Rosalind A.} and Easton, {Douglas F.} and Zsofia Kote-Jarai and {Al Olama}, {Ali Amin} and Sara Benlloch and Kenneth Muir and Giles, {Graham G.} and Southey, {Melissa C.} and Fitzgerald, {Liesel M.} and Henderson, {Brian E.} and Schumacher, {Fredrick R.} and Haiman, {Christopher A.} and Csilla Sipeky and Tammela, {Teuvol J.} and Nordestgaard, {B{\o}rge G.} and Key, {Timothy J.} and Travis, {Ruth C.} and Neal, {David E.} and Donovan, {Jenny L.} and Hamdy, {Freddie C.} and Pharoah, {Paul D.P.} and Nora Pashayan and Khaw, {Kay Tee} and Stanford, {Janet L.} and Thibodeau, {Stephen N.} and McDonnell, {Shannon K.} and Schaid, {Daniel J.} and Christiane Maier and Walther Vogel and Manuel Luedeke and Kathleen Herkommer and Kibel, {Adam S.} and Cezary Cybulski and Jan Lubinski and Wojciech Kluzniak and Lisa Cannon-Albright and Hermann Brenner and Volker Herrmann and Bernd Holleczek and Park, {Jong Y.} and Sellers, {Thomas A.} and Lim, {Hui Yi} and Chavdar Slavov and Kaneva, {Radka P.} and Mitev, {Vanio I.} and Amanda Spurdle and Teixeira, {Manuel R.} and Paula Paulo and Sofia Maia and Hardev Pandha and Agnieszka Michael and Andrzej Kierzek and Jyotsna Batra and Clements, {Judith A.} and Demetrius Albanes and Andriole, {Gerald L.} and Berndt, {Sonja I.} and Stephen Chanock and Gapstur, {Susan M.} and Giovannucci, {Edward L.} and Hunter, {David J.} and Peter Kraft and {Le Marchand}, Loic and Jing Ma and Mondul, {Alison M.} and Penney, {Kathryn L.} and Stampfer, {Meir J.} and Stevens, {Victoria L.} and Weinstein, {Stephanie J.} and Antonia Trichopoulou and Bueno-De-mesquita, {Bas H.} and Anne Tj{\o}nneland and Cox, {David G.} and Lovise Maehle and Johanna Schleutker and Sara Lindstrom and Fredrik Wiklund",

note = "Publisher Copyright: {\textcopyright} 2015 AACR.",

year = "2015",

month = nov,

doi = "10.1158/1055-9965.EPI-15-0543",

language = "English (US)",

volume = "24",

pages = "1796--1800",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

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TY - JOUR

T1 - Genome-wide association study of prostate cancer-specific survival

AU - Szulkin, Robert

AU - Karlsson, Robert

AU - Whitington, Thomas

AU - Aly, Markus

AU - Gronberg, Henrik

AU - Eeles, Rosalind A.

AU - Easton, Douglas F.

AU - Kote-Jarai, Zsofia

AU - Al Olama, Ali Amin

AU - Benlloch, Sara

AU - Muir, Kenneth

AU - Giles, Graham G.

AU - Southey, Melissa C.

AU - Fitzgerald, Liesel M.

AU - Henderson, Brian E.

AU - Schumacher, Fredrick R.

AU - Haiman, Christopher A.

AU - Sipeky, Csilla

AU - Tammela, Teuvol J.

AU - Nordestgaard, Børge G.

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Neal, David E.

AU - Donovan, Jenny L.

AU - Hamdy, Freddie C.

AU - Pharoah, Paul D.P.

AU - Pashayan, Nora

AU - Khaw, Kay Tee

AU - Stanford, Janet L.

AU - Thibodeau, Stephen N.

AU - McDonnell, Shannon K.

AU - Schaid, Daniel J.

AU - Maier, Christiane

AU - Vogel, Walther

AU - Luedeke, Manuel

AU - Herkommer, Kathleen

AU - Kibel, Adam S.

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Kluzniak, Wojciech

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Herrmann, Volker

AU - Holleczek, Bernd

AU - Park, Jong Y.

AU - Sellers, Thomas A.

AU - Lim, Hui Yi

AU - Slavov, Chavdar

AU - Kaneva, Radka P.

AU - Mitev, Vanio I.

AU - Spurdle, Amanda

AU - Teixeira, Manuel R.

AU - Paulo, Paula

AU - Maia, Sofia

AU - Pandha, Hardev

AU - Michael, Agnieszka

AU - Kierzek, Andrzej

AU - Batra, Jyotsna

AU - Clements, Judith A.

AU - Albanes, Demetrius

AU - Andriole, Gerald L.

AU - Berndt, Sonja I.

AU - Chanock, Stephen

AU - Gapstur, Susan M.

AU - Giovannucci, Edward L.

AU - Hunter, David J.

AU - Kraft, Peter

AU - Le Marchand, Loic

AU - Ma, Jing

AU - Mondul, Alison M.

AU - Penney, Kathryn L.

AU - Stampfer, Meir J.

AU - Stevens, Victoria L.

AU - Weinstein, Stephanie J.

AU - Trichopoulou, Antonia

AU - Bueno-De-mesquita, Bas H.

AU - Tjønneland, Anne

AU - Cox, David G.

AU - Maehle, Lovise

AU - Schleutker, Johanna

AU - Lindstrom, Sara

AU - Wiklund, Fredrik

PY - 2015/11

Y1 - 2015/11

N2 - Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

AB - Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

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U2 - 10.1158/1055-9965.EPI-15-0543

DO - 10.1158/1055-9965.EPI-15-0543

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AN - SCOPUS:84946594253

SN - 1055-9965

VL - 24

SP - 1796

EP - 1800

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 11

ER -

Genome-wide association study of prostate cancer-specific survival

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