Genome-wide association study of personality traits in the long life family study

Harold T. Bae; Paola Sebastiani; Jenny X. Sun; Stacy L. Andersen; E. Warwick Daw; Antonio Terracciano; Luigi Ferrucci; Thomas T. Perls

doi:10.3389/fgene.2013.00065

Genome-wide association study of personality traits in the long life family study

Harold T. Bae, Paola Sebastiani, Jenny X. Sun, Stacy L. Andersen, E. Warwick Daw, Antonio Terracciano, Luigi Ferrucci, Thomas T. Perls

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p <10^-8) and replicated in an additional sample of 1279 LLFS subjects, although one (rs9650241) failed to replicate and the other two were not available in two independent replication cohorts, the Baltimore Longitudinal Study of Aging and the New England Centenarian Study. Based on 10,000,000 permutations, the empirical p-value of 2 × 10^-7 was observed for the genome-wide significant SNPs. Seventeen SNPs that reached marginal statistical significance in the two previous GWASs (p-value -4 and 10^-5), were also marginally significantly associated in this study (p-value

Original language	English (US)
Article number	Article 65
Journal	Frontiers in Genetics
Volume	4
Issue number	MAY
DOIs	https://doi.org/10.3389/fgene.2013.00065
State	Published - 2013
Externally published	Yes

Keywords

Family study
Gene-environment interaction
GWAS
Longevity
Neo scores

ASJC Scopus subject areas

Genetics
Molecular Medicine
Genetics(clinical)

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10.3389/fgene.2013.00065

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abstract = "Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p <10-8) and replicated in an additional sample of 1279 LLFS subjects, although one (rs9650241) failed to replicate and the other two were not available in two independent replication cohorts, the Baltimore Longitudinal Study of Aging and the New England Centenarian Study. Based on 10,000,000 permutations, the empirical p-value of 2 × 10-7 was observed for the genome-wide significant SNPs. Seventeen SNPs that reached marginal statistical significance in the two previous GWASs (p-value -4 and 10-5), were also marginally significantly associated in this study (p-value ",

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AU - Sebastiani, Paola

AU - Sun, Jenny X.

AU - Andersen, Stacy L.

AU - Daw, E. Warwick

AU - Terracciano, Antonio

AU - Ferrucci, Luigi

AU - Perls, Thomas T.

PY - 2013

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AB - Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p <10-8) and replicated in an additional sample of 1279 LLFS subjects, although one (rs9650241) failed to replicate and the other two were not available in two independent replication cohorts, the Baltimore Longitudinal Study of Aging and the New England Centenarian Study. Based on 10,000,000 permutations, the empirical p-value of 2 × 10-7 was observed for the genome-wide significant SNPs. Seventeen SNPs that reached marginal statistical significance in the two previous GWASs (p-value -4 and 10-5), were also marginally significantly associated in this study (p-value

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Genome-wide association study of personality traits in the long life family study

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Keywords

ASJC Scopus subject areas

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