Genome-wide association study of personality traits in the long life family study

Harold T. Bae, Paola Sebastiani, Jenny X. Sun, Stacy L. Andersen, E. Warwick Daw, Antonio Terracciano, Luigi Ferrucci, Thomas T. Perls

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p <10-8) and replicated in an additional sample of 1279 LLFS subjects, although one (rs9650241) failed to replicate and the other two were not available in two independent replication cohorts, the Baltimore Longitudinal Study of Aging and the New England Centenarian Study. Based on 10,000,000 permutations, the empirical p-value of 2 × 10-7 was observed for the genome-wide significant SNPs. Seventeen SNPs that reached marginal statistical significance in the two previous GWASs (p-value -4 and 10-5), were also marginally significantly associated in this study (p-value

Original languageEnglish (US)
Article numberArticle 65
JournalFrontiers in Genetics
Issue numberMAY
StatePublished - 2013
Externally publishedYes


  • Family study
  • Gene-environment interaction
  • GWAS
  • Longevity
  • Neo scores

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Genetics(clinical)


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