Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy

Xin Liu, Xiumei Hong, Hui Ju Tsai, Karen K. Mestan, Min Shi, Amira Kefi, Ke Hao, Qi Chen, Guoying Wang, Deanna Caruso, Hua Geng, Yufeng Gao, Jianlin He, Rajesh Kumar, Hongjian Wang, Yunxian Yu, Tami Bartell, Xiao Di Tan, Robert P. Schleimer, Daniel E. Weeks & 2 others Jacqueline A. Pongracic, Xiaobin Wang

Research output: Contribution to journalArticle

Abstract

Previous genetic studies of food allergy (FA) have mainly focused on inherited genotypic effects. The role of parental genotypic effects remains largely unexplored. Leveraging existing genome-wide association study (GWAS) data generated from the Chicago Food Allergy Study, we examined maternal genotypic and parent-of-origin (PO) effects using multinomial likelihood ratio tests in 588 complete and incomplete Caucasian FA trios. We identified 1 single nucleotide polymorphism with significant (P < 5×10) maternal effect on any FA (rs4235235), which is located in a noncoding RNA (LOC101927947) with unknown function. We also identified 3 suggestive (P < 5×10) loci with maternal genetic effects: 1 for any FA (rs976078, in a gene desert region on 13q31.1) and 2 for egg allergy (rs1343795 and rs4572450, in the ZNF652 gene, where genetic variants have been associated with atopic dermatitis). Three suggestive loci with PO effect were observed: 1 for peanut allergy (rs4896888 in the ADGB gene) and 2 for any FA in boys only (rs1036504 and rs2917750 in the IQCE gene). Findings from this family-based GWAS of FA provided some preliminary evidence on maternal genotypic or PO effects on FA. Additional family-based studies are needed to confirm our findings and gain new insight into maternal and paternal genetic contribution to FA.

Original languageEnglish (US)
Pages (from-to)e0043
JournalMedicine
Volume97
Issue number9
DOIs
StatePublished - Mar 1 2018

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Food Hypersensitivity
Genome-Wide Association Study
Mothers
Genes
Egg Hypersensitivity
Peanut Hypersensitivity
Maternal Inheritance
Untranslated RNA
Atopic Dermatitis
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Medicine(all)

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Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. / Liu, Xin; Hong, Xiumei; Tsai, Hui Ju; Mestan, Karen K.; Shi, Min; Kefi, Amira; Hao, Ke; Chen, Qi; Wang, Guoying; Caruso, Deanna; Geng, Hua; Gao, Yufeng; He, Jianlin; Kumar, Rajesh; Wang, Hongjian; Yu, Yunxian; Bartell, Tami; Tan, Xiao Di; Schleimer, Robert P.; Weeks, Daniel E.; Pongracic, Jacqueline A.; Wang, Xiaobin.

In: Medicine, Vol. 97, No. 9, 01.03.2018, p. e0043.

Research output: Contribution to journalArticle

Liu, X, Hong, X, Tsai, HJ, Mestan, KK, Shi, M, Kefi, A, Hao, K, Chen, Q, Wang, G, Caruso, D, Geng, H, Gao, Y, He, J, Kumar, R, Wang, H, Yu, Y, Bartell, T, Tan, XD, Schleimer, RP, Weeks, DE, Pongracic, JA & Wang, X 2018, 'Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy', Medicine, vol. 97, no. 9, pp. e0043. https://doi.org/10.1097/MD.0000000000010043
Liu, Xin ; Hong, Xiumei ; Tsai, Hui Ju ; Mestan, Karen K. ; Shi, Min ; Kefi, Amira ; Hao, Ke ; Chen, Qi ; Wang, Guoying ; Caruso, Deanna ; Geng, Hua ; Gao, Yufeng ; He, Jianlin ; Kumar, Rajesh ; Wang, Hongjian ; Yu, Yunxian ; Bartell, Tami ; Tan, Xiao Di ; Schleimer, Robert P. ; Weeks, Daniel E. ; Pongracic, Jacqueline A. ; Wang, Xiaobin. / Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. In: Medicine. 2018 ; Vol. 97, No. 9. pp. e0043.
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AU - Shi, Min

AU - Kefi, Amira

AU - Hao, Ke

AU - Chen, Qi

AU - Wang, Guoying

AU - Caruso, Deanna

AU - Geng, Hua

AU - Gao, Yufeng

AU - He, Jianlin

AU - Kumar, Rajesh

AU - Wang, Hongjian

AU - Yu, Yunxian

AU - Bartell, Tami

AU - Tan, Xiao Di

AU - Schleimer, Robert P.

AU - Weeks, Daniel E.

AU - Pongracic, Jacqueline A.

AU - Wang, Xiaobin

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