Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Lucia Conde, Eran Halperin, Nicholas K. Akers, Kevin M. Brown, Karin E. Smedby, Nathaniel Rothman, Alexandra Nieters, Susan L. Slager, Angela Brooks-Wilson, Luz Agana, Jacques Riby, Jianjun Liu, Hans Olov Adami, Hatef Darabi, Henrik Hjalgrim, Hui Qi Low, Keith Humphreys, Mads Melbye, Ellen T. Chang, Bengt GlimeliusWendy Cozen, Scott Davis, Patricia Hartge, Lindsay M. Morton, Maryjean Schenk, Sophia S. Wang, Bruce Armstrong, Anne Kricker, Sam Milliken, Mark P. Purdue, Claire M. Vajdic, Peter Boyle, Qing Lan, Shelia H. Zahm, Yawei Zhang, Tongzhang Zheng, Nikolaus Becker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Katja Butterbach, Pierluigi Cocco, Lenka Foretova, Marc Maynadié, Silvia De Sanjosé, Anthony Staines, John J. Spinelli, Sara J. Achenbach, Timothy G. Call, Nicola J. Camp, Martha Glenn, Neil E. Caporaso, James R. Cerhan, Julie M. Cunningham, Lynn R. Goldin, Curtis A. Hanson, Neil E. Kay, Mark C. Lanasa, Jose F. Leis, Gerald E. Marti, Kari G. Rabe, Laura Z. Rassenti, Logan G. Spector, Sara S. Strom, Celine M. Vachon, J. Brice Weinberg, Elizabeth A. Holly, Stephen Chanock, Martyn T. Smith, Paige M. Bracci, Christine F. Skibola

Research output: Contribution to journalArticle

Abstract

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10-29 and rs7755224, combined P = 2.00 × 10-19; r2 = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10-9).

Original languageEnglish (US)
Pages (from-to)661-664
Number of pages4
JournalNature genetics
Volume42
Issue number8
DOIs
StatePublished - Aug 2010

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32'. Together they form a unique fingerprint.

  • Cite this

    Conde, L., Halperin, E., Akers, N. K., Brown, K. M., Smedby, K. E., Rothman, N., Nieters, A., Slager, S. L., Brooks-Wilson, A., Agana, L., Riby, J., Liu, J., Adami, H. O., Darabi, H., Hjalgrim, H., Low, H. Q., Humphreys, K., Melbye, M., Chang, E. T., ... Skibola, C. F. (2010). Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nature genetics, 42(8), 661-664. https://doi.org/10.1038/ng.626