Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.

Li Dong Wang, Fu You Zhou, Xue Min Li, Liang Dan Sun, Xin Song, Yan Jin, Jiang Man Li, Guo Qiang Kong, Hong Qi, Juan Cui, Lian Qun Zhang, Jie Zhi Yang, Ji Lin Li, Xing Chuan Li, Jing Li Ren, Zhi Cai Liu, Wen Jun Gao, Ling Yuan, W. Wei, Yan Rui ZhangWei Peng Wang, Ilyar Sheyhidin, Feng Li, Bao Ping Chen, Shu Wei Ren, Bin Liu, Dan Li, Jian Wei Ku, Zong Min Fan, Sheng Li Zhou, Zhi Gang Guo, Xue Ke Zhao, N. Liu, Yong Hong Ai, Fang Fang Shen, Wen Yan Cui, Shuang Song, Tao Guo, Jing Huang, Chao Yuan, Jia Huang, Yue Wu, Wen Bin Yue, Chang Wei Feng, Hong Lei Li, Yan Wang, Jin Ya Tian, Yue Lu, Y. Yuan, Wen Liang Zhu, Min Liu, Wen Jing Fu, Xia Yang, Han Jing Wang, Suo Li Han, Jie Chen, Min Han, Hai Yan Wang, Peng Zhang, Xiu Min Li, Jin Cheng Dong, Guo Lan Xing, Ran Wang, Ming Guo, Zhi Wei Chang, Hai Lin Liu, L. Guo, Zhi Qing Yuan, Hai Liu, Qin Lu, Liu Qin Yang, Fu Guo Zhu, Xiu Feng Yang, Xiao Shan Feng, Zhou Wang, Yin Li, She Gan Gao, Qirenwang Qige, Long Tang Bai, Wen Jun Yang, Guang Yan Lei, Zhong Ying Shen, Long Qi Chen, En Min Li, Li Yan Xu, Zhi Yong Wu, Wei Ke Cao, Jian Po Wang, Zhi Qin Bao, Ji Li Chen, Guang Cheng Ding, Xiang Zhuang, Ying Fa Zhou, Hou Feng Zheng, Zheng Zhang, Xian Bo Zuo, Zi Ming Dong, Dong Mei Fan, Xin He

Research output: Contribution to journalArticle

Abstract

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

Original languageEnglish (US)
Pages (from-to)759-763
Number of pages5
JournalNature Genetics
Volume42
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

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Genome-Wide Association Study
Odds Ratio
Esophageal Squamous Cell Carcinoma
Riboflavin Deficiency
Cardia
Riboflavin
Single Nucleotide Polymorphism
Cell Differentiation
Stomach
Adenocarcinoma
Apoptosis

ASJC Scopus subject areas

  • Genetics

Cite this

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. / Wang, Li Dong; Zhou, Fu You; Li, Xue Min; Sun, Liang Dan; Song, Xin; Jin, Yan; Li, Jiang Man; Kong, Guo Qiang; Qi, Hong; Cui, Juan; Zhang, Lian Qun; Yang, Jie Zhi; Li, Ji Lin; Li, Xing Chuan; Ren, Jing Li; Liu, Zhi Cai; Gao, Wen Jun; Yuan, Ling; Wei, W.; Zhang, Yan Rui; Wang, Wei Peng; Sheyhidin, Ilyar; Li, Feng; Chen, Bao Ping; Ren, Shu Wei; Liu, Bin; Li, Dan; Ku, Jian Wei; Fan, Zong Min; Zhou, Sheng Li; Guo, Zhi Gang; Zhao, Xue Ke; Liu, N.; Ai, Yong Hong; Shen, Fang Fang; Cui, Wen Yan; Song, Shuang; Guo, Tao; Huang, Jing; Yuan, Chao; Huang, Jia; Wu, Yue; Yue, Wen Bin; Feng, Chang Wei; Li, Hong Lei; Wang, Yan; Tian, Jin Ya; Lu, Yue; Yuan, Y.; Zhu, Wen Liang; Liu, Min; Fu, Wen Jing; Yang, Xia; Wang, Han Jing; Han, Suo Li; Chen, Jie; Han, Min; Wang, Hai Yan; Zhang, Peng; Li, Xiu Min; Dong, Jin Cheng; Xing, Guo Lan; Wang, Ran; Guo, Ming; Chang, Zhi Wei; Liu, Hai Lin; Guo, L.; Yuan, Zhi Qing; Liu, Hai; Lu, Qin; Yang, Liu Qin; Zhu, Fu Guo; Yang, Xiu Feng; Feng, Xiao Shan; Wang, Zhou; Li, Yin; Gao, She Gan; Qige, Qirenwang; Bai, Long Tang; Yang, Wen Jun; Lei, Guang Yan; Shen, Zhong Ying; Chen, Long Qi; Li, En Min; Xu, Li Yan; Wu, Zhi Yong; Cao, Wei Ke; Wang, Jian Po; Bao, Zhi Qin; Chen, Ji Li; Ding, Guang Cheng; Zhuang, Xiang; Zhou, Ying Fa; Zheng, Hou Feng; Zhang, Zheng; Zuo, Xian Bo; Dong, Zi Ming; Fan, Dong Mei; He, Xin.

In: Nature Genetics, Vol. 42, No. 9, 09.2010, p. 759-763.

Research output: Contribution to journalArticle

Wang, LD, Zhou, FY, Li, XM, Sun, LD, Song, X, Jin, Y, Li, JM, Kong, GQ, Qi, H, Cui, J, Zhang, LQ, Yang, JZ, Li, JL, Li, XC, Ren, JL, Liu, ZC, Gao, WJ, Yuan, L, Wei, W, Zhang, YR, Wang, WP, Sheyhidin, I, Li, F, Chen, BP, Ren, SW, Liu, B, Li, D, Ku, JW, Fan, ZM, Zhou, SL, Guo, ZG, Zhao, XK, Liu, N, Ai, YH, Shen, FF, Cui, WY, Song, S, Guo, T, Huang, J, Yuan, C, Huang, J, Wu, Y, Yue, WB, Feng, CW, Li, HL, Wang, Y, Tian, JY, Lu, Y, Yuan, Y, Zhu, WL, Liu, M, Fu, WJ, Yang, X, Wang, HJ, Han, SL, Chen, J, Han, M, Wang, HY, Zhang, P, Li, XM, Dong, JC, Xing, GL, Wang, R, Guo, M, Chang, ZW, Liu, HL, Guo, L, Yuan, ZQ, Liu, H, Lu, Q, Yang, LQ, Zhu, FG, Yang, XF, Feng, XS, Wang, Z, Li, Y, Gao, SG, Qige, Q, Bai, LT, Yang, WJ, Lei, GY, Shen, ZY, Chen, LQ, Li, EM, Xu, LY, Wu, ZY, Cao, WK, Wang, JP, Bao, ZQ, Chen, JL, Ding, GC, Zhuang, X, Zhou, YF, Zheng, HF, Zhang, Z, Zuo, XB, Dong, ZM, Fan, DM & He, X 2010, 'Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.', Nature Genetics, vol. 42, no. 9, pp. 759-763. https://doi.org/10.1038/ng.648
Wang, Li Dong ; Zhou, Fu You ; Li, Xue Min ; Sun, Liang Dan ; Song, Xin ; Jin, Yan ; Li, Jiang Man ; Kong, Guo Qiang ; Qi, Hong ; Cui, Juan ; Zhang, Lian Qun ; Yang, Jie Zhi ; Li, Ji Lin ; Li, Xing Chuan ; Ren, Jing Li ; Liu, Zhi Cai ; Gao, Wen Jun ; Yuan, Ling ; Wei, W. ; Zhang, Yan Rui ; Wang, Wei Peng ; Sheyhidin, Ilyar ; Li, Feng ; Chen, Bao Ping ; Ren, Shu Wei ; Liu, Bin ; Li, Dan ; Ku, Jian Wei ; Fan, Zong Min ; Zhou, Sheng Li ; Guo, Zhi Gang ; Zhao, Xue Ke ; Liu, N. ; Ai, Yong Hong ; Shen, Fang Fang ; Cui, Wen Yan ; Song, Shuang ; Guo, Tao ; Huang, Jing ; Yuan, Chao ; Huang, Jia ; Wu, Yue ; Yue, Wen Bin ; Feng, Chang Wei ; Li, Hong Lei ; Wang, Yan ; Tian, Jin Ya ; Lu, Yue ; Yuan, Y. ; Zhu, Wen Liang ; Liu, Min ; Fu, Wen Jing ; Yang, Xia ; Wang, Han Jing ; Han, Suo Li ; Chen, Jie ; Han, Min ; Wang, Hai Yan ; Zhang, Peng ; Li, Xiu Min ; Dong, Jin Cheng ; Xing, Guo Lan ; Wang, Ran ; Guo, Ming ; Chang, Zhi Wei ; Liu, Hai Lin ; Guo, L. ; Yuan, Zhi Qing ; Liu, Hai ; Lu, Qin ; Yang, Liu Qin ; Zhu, Fu Guo ; Yang, Xiu Feng ; Feng, Xiao Shan ; Wang, Zhou ; Li, Yin ; Gao, She Gan ; Qige, Qirenwang ; Bai, Long Tang ; Yang, Wen Jun ; Lei, Guang Yan ; Shen, Zhong Ying ; Chen, Long Qi ; Li, En Min ; Xu, Li Yan ; Wu, Zhi Yong ; Cao, Wei Ke ; Wang, Jian Po ; Bao, Zhi Qin ; Chen, Ji Li ; Ding, Guang Cheng ; Zhuang, Xiang ; Zhou, Ying Fa ; Zheng, Hou Feng ; Zhang, Zheng ; Zuo, Xian Bo ; Dong, Zi Ming ; Fan, Dong Mei ; He, Xin. / Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. In: Nature Genetics. 2010 ; Vol. 42, No. 9. pp. 759-763.
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title = "Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.",
abstract = "We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.",
author = "Wang, {Li Dong} and Zhou, {Fu You} and Li, {Xue Min} and Sun, {Liang Dan} and Xin Song and Yan Jin and Li, {Jiang Man} and Kong, {Guo Qiang} and Hong Qi and Juan Cui and Zhang, {Lian Qun} and Yang, {Jie Zhi} and Li, {Ji Lin} and Li, {Xing Chuan} and Ren, {Jing Li} and Liu, {Zhi Cai} and Gao, {Wen Jun} and Ling Yuan and W. Wei and Zhang, {Yan Rui} and Wang, {Wei Peng} and Ilyar Sheyhidin and Feng Li and Chen, {Bao Ping} and Ren, {Shu Wei} and Bin Liu and Dan Li and Ku, {Jian Wei} and Fan, {Zong Min} and Zhou, {Sheng Li} and Guo, {Zhi Gang} and Zhao, {Xue Ke} and N. Liu and Ai, {Yong Hong} and Shen, {Fang Fang} and Cui, {Wen Yan} and Shuang Song and Tao Guo and Jing Huang and Chao Yuan and Jia Huang and Yue Wu and Yue, {Wen Bin} and Feng, {Chang Wei} and Li, {Hong Lei} and Yan Wang and Tian, {Jin Ya} and Yue Lu and Y. Yuan and Zhu, {Wen Liang} and Min Liu and Fu, {Wen Jing} and Xia Yang and Wang, {Han Jing} and Han, {Suo Li} and Jie Chen and Min Han and Wang, {Hai Yan} and Peng Zhang and Li, {Xiu Min} and Dong, {Jin Cheng} and Xing, {Guo Lan} and Ran Wang and Ming Guo and Chang, {Zhi Wei} and Liu, {Hai Lin} and L. Guo and Yuan, {Zhi Qing} and Hai Liu and Qin Lu and Yang, {Liu Qin} and Zhu, {Fu Guo} and Yang, {Xiu Feng} and Feng, {Xiao Shan} and Zhou Wang and Yin Li and Gao, {She Gan} and Qirenwang Qige and Bai, {Long Tang} and Yang, {Wen Jun} and Lei, {Guang Yan} and Shen, {Zhong Ying} and Chen, {Long Qi} and Li, {En Min} and Xu, {Li Yan} and Wu, {Zhi Yong} and Cao, {Wei Ke} and Wang, {Jian Po} and Bao, {Zhi Qin} and Chen, {Ji Li} and Ding, {Guang Cheng} and Xiang Zhuang and Zhou, {Ying Fa} and Zheng, {Hou Feng} and Zheng Zhang and Zuo, {Xian Bo} and Dong, {Zi Ming} and Fan, {Dong Mei} and Xin He",
year = "2010",
month = "9",
doi = "10.1038/ng.648",
language = "English (US)",
volume = "42",
pages = "759--763",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
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TY - JOUR

T1 - Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.

AU - Wang, Li Dong

AU - Zhou, Fu You

AU - Li, Xue Min

AU - Sun, Liang Dan

AU - Song, Xin

AU - Jin, Yan

AU - Li, Jiang Man

AU - Kong, Guo Qiang

AU - Qi, Hong

AU - Cui, Juan

AU - Zhang, Lian Qun

AU - Yang, Jie Zhi

AU - Li, Ji Lin

AU - Li, Xing Chuan

AU - Ren, Jing Li

AU - Liu, Zhi Cai

AU - Gao, Wen Jun

AU - Yuan, Ling

AU - Wei, W.

AU - Zhang, Yan Rui

AU - Wang, Wei Peng

AU - Sheyhidin, Ilyar

AU - Li, Feng

AU - Chen, Bao Ping

AU - Ren, Shu Wei

AU - Liu, Bin

AU - Li, Dan

AU - Ku, Jian Wei

AU - Fan, Zong Min

AU - Zhou, Sheng Li

AU - Guo, Zhi Gang

AU - Zhao, Xue Ke

AU - Liu, N.

AU - Ai, Yong Hong

AU - Shen, Fang Fang

AU - Cui, Wen Yan

AU - Song, Shuang

AU - Guo, Tao

AU - Huang, Jing

AU - Yuan, Chao

AU - Huang, Jia

AU - Wu, Yue

AU - Yue, Wen Bin

AU - Feng, Chang Wei

AU - Li, Hong Lei

AU - Wang, Yan

AU - Tian, Jin Ya

AU - Lu, Yue

AU - Yuan, Y.

AU - Zhu, Wen Liang

AU - Liu, Min

AU - Fu, Wen Jing

AU - Yang, Xia

AU - Wang, Han Jing

AU - Han, Suo Li

AU - Chen, Jie

AU - Han, Min

AU - Wang, Hai Yan

AU - Zhang, Peng

AU - Li, Xiu Min

AU - Dong, Jin Cheng

AU - Xing, Guo Lan

AU - Wang, Ran

AU - Guo, Ming

AU - Chang, Zhi Wei

AU - Liu, Hai Lin

AU - Guo, L.

AU - Yuan, Zhi Qing

AU - Liu, Hai

AU - Lu, Qin

AU - Yang, Liu Qin

AU - Zhu, Fu Guo

AU - Yang, Xiu Feng

AU - Feng, Xiao Shan

AU - Wang, Zhou

AU - Li, Yin

AU - Gao, She Gan

AU - Qige, Qirenwang

AU - Bai, Long Tang

AU - Yang, Wen Jun

AU - Lei, Guang Yan

AU - Shen, Zhong Ying

AU - Chen, Long Qi

AU - Li, En Min

AU - Xu, Li Yan

AU - Wu, Zhi Yong

AU - Cao, Wei Ke

AU - Wang, Jian Po

AU - Bao, Zhi Qin

AU - Chen, Ji Li

AU - Ding, Guang Cheng

AU - Zhuang, Xiang

AU - Zhou, Ying Fa

AU - Zheng, Hou Feng

AU - Zhang, Zheng

AU - Zuo, Xian Bo

AU - Dong, Zi Ming

AU - Fan, Dong Mei

AU - He, Xin

PY - 2010/9

Y1 - 2010/9

N2 - We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

AB - We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

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