Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders

Frederick W. Miller, Robert G. Cooper, Jiří Vencovský, Lisa G. Rider, Katalin Danko, Lucy R. Wedderburn, Ingrid E. Lundberg, Lauren M. Pachman, Ann M. Reed, Steven R. Ytterberg, Leonid Padyukov, Albert Selva-O'Callaghan, Timothy R D J Radstake, David A. Isenberg, Hector Chinoy, William E R Ollier, Terrance P. O'Hanlon, Bo Peng, Annette Lee, Janine A. LambWei Chen, Christopher I. Amos, Peter K. Gregersen, Christopher Denton, David Hilton-Jones, Patrick Kiely, Paul H. Plotz, Mark Gourley, Paul Scheet, Hemlata Varsani

Research output: Contribution to journalArticlepeer-review


Objective: To identify new genetic associations with juvenile and adult dermatomyositis (DM). Methods: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM. Results: Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P <5 × 10-8) at 80 genotyped SNPs. An analysis of 141 non-MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of

Original languageEnglish (US)
Pages (from-to)3239-3247
Number of pages9
JournalArthritis and Rheumatism
Issue number12
StatePublished - Dec 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Rheumatology
  • Pharmacology (medical)

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