TY - JOUR
T1 - Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders
AU - Miller, Frederick W.
AU - Cooper, Robert G.
AU - Vencovský, Jiří
AU - Rider, Lisa G.
AU - Danko, Katalin
AU - Wedderburn, Lucy R.
AU - Lundberg, Ingrid E.
AU - Pachman, Lauren M.
AU - Reed, Ann M.
AU - Ytterberg, Steven R.
AU - Padyukov, Leonid
AU - Selva-O'Callaghan, Albert
AU - Radstake, Timothy R D J
AU - Isenberg, David A.
AU - Chinoy, Hector
AU - Ollier, William E R
AU - O'Hanlon, Terrance P.
AU - Peng, Bo
AU - Lee, Annette
AU - Lamb, Janine A.
AU - Chen, Wei
AU - Amos, Christopher I.
AU - Gregersen, Peter K.
AU - Denton, Christopher
AU - Hilton-Jones, David
AU - Kiely, Patrick
AU - Plotz, Paul H.
AU - Gourley, Mark
AU - Scheet, Paul
AU - Varsani, Hemlata
PY - 2013/12
Y1 - 2013/12
N2 - Objective: To identify new genetic associations with juvenile and adult dermatomyositis (DM). Methods: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM. Results: Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P <5 × 10-8) at 80 genotyped SNPs. An analysis of 141 non-MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of
AB - Objective: To identify new genetic associations with juvenile and adult dermatomyositis (DM). Methods: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM. Results: Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P <5 × 10-8) at 80 genotyped SNPs. An analysis of 141 non-MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of
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U2 - 10.1002/art.38137
DO - 10.1002/art.38137
M3 - Article
C2 - 23983088
AN - SCOPUS:84889070882
SN - 0004-3591
VL - 65
SP - 3239
EP - 3247
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
IS - 12
ER -