Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Fredrick R. Schumacher; Stephanie L. Schmit; Shuo Jiao; Christopher K. Edlund; Hansong Wang; Ben Zhang; Li Hsu; Shu Chen Huang; Christopher P. Fischer; John F. Harju; Gregory E. Idos; Flavio Lejbkowicz; Frank J. Manion; Kevin McDonnell; Caroline E. McNeil; Marilena Melas; Hedy S. Rennert; Wei Shi; Duncan C. Thomas; David J. Van Den Berg; Carolyn M. Hutter; Aaron K. Aragaki; Katja Butterbach; Bette J. Caan; Christopher S. Carlson; Stephen J. Chanock; Keith R. Curtis; Charles S. Fuchs; Manish Gala; Edward L. Giocannucci; Stephanie M. Gogarten; Richard B. Hayes; Brian Henderson; David J. Hunter; Rebecca D. Jackson; Laurence N. Kolonel; Charles Kooperberg; Sebastian Kury; Andrea Lacroix; Cathy C. Laurie; Cecelia A. Laurie; Mathiew Lemire; David Levine; Jing Ma; Karen W. Makar; Conghui Qu; Darin Taverna; Cornelia M. Ulrich; Kana Wu; Suminori Kono; Dee W. West; Sonja I. Berndt; Stephane Bezieau; Hermann Brenner; Peter T. Campbell; Andrew T. Chan; Jenny Chang-Claude; Gerhard A. Coetzee; David V. Conti; David Duggan; Jane C. Figueiredo; Barbara K. Fortini; Steven J. Gallinger; W. James Gauderman; Graham Giles; Roger Green; Robert Haile; Tabitha A. Harrison; Michael Hoffmeister; John L. Hopper; Thomas J. Hudson; Eric Jacobs; Motoki Iwasaki; Sun Ha Jee; Mark Jenkins; Wei Hua Jia; Amit Joshi; Li Li; Noralene M. Lindor; Keitaro Matsuo; Victor Moreno; Bhramar Mukherjee; Polly A. Newcomb; John D. Potter; Leon Raskin; Gad Rennert; Stephanie Rosse; Gianluca Severi; Robert E. Schoen; Daniela Seminara; Xiao Ou Shu; Martha L. Slattery; Shoichiro Tsugane; Emily White; Yong Bing Xiang; Brent W. Zanke; Wei Zheng; Loic Le Marchand; Graham Casey; Stephen B. Gruber; Ulrike Peters

doi:10.1038/ncomms8138

Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Fredrick R. Schumacher, Stephanie L. Schmit, Shuo Jiao, Christopher K. Edlund, Hansong Wang, Ben Zhang, Li Hsu, Shu Chen Huang, Christopher P. Fischer, John F. Harju, Gregory E. Idos, Flavio Lejbkowicz, Frank J. Manion, Kevin McDonnell, Caroline E. McNeil, Marilena Melas, Hedy S. Rennert, Wei Shi, Duncan C. Thomas, David J. Van Den BergCarolyn M. Hutter, Aaron K. Aragaki, Katja Butterbach, Bette J. Caan, Christopher S. Carlson, Stephen J. Chanock, Keith R. Curtis, Charles S. Fuchs, Manish Gala, Edward L. Giocannucci, Stephanie M. Gogarten, Richard B. Hayes, Brian Henderson, David J. Hunter, Rebecca D. Jackson, Laurence N. Kolonel, Charles Kooperberg, Sebastian Kury, Andrea Lacroix, Cathy C. Laurie, Cecelia A. Laurie, Mathiew Lemire, David Levine, Jing Ma, Karen W. Makar, Conghui Qu, Darin Taverna, Cornelia M. Ulrich, Kana Wu, Suminori Kono, Dee W. West, Sonja I. Berndt, Stephane Bezieau, Hermann Brenner, Peter T. Campbell, Andrew T. Chan, Jenny Chang-Claude, Gerhard A. Coetzee, David V. Conti, David Duggan, Jane C. Figueiredo, Barbara K. Fortini, Steven J. Gallinger, W. James Gauderman, Graham Giles, Roger Green, Robert Haile, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Thomas J. Hudson, Eric Jacobs, Motoki Iwasaki, Sun Ha Jee, Mark Jenkins, Wei Hua Jia, Amit Joshi, Li Li, Noralene M. Lindor, Keitaro Matsuo, Victor Moreno, Bhramar Mukherjee, Polly A. Newcomb, John D. Potter, Leon Raskin, Gad Rennert, Stephanie Rosse, Gianluca Severi, Robert E. Schoen, Daniela Seminara, Xiao Ou Shu, Martha L. Slattery, Shoichiro Tsugane, Emily White, Yong Bing Xiang, Brent W. Zanke, Wei Zheng, Loic Le Marchand, Graham Casey, Stephen B. Gruber, Ulrike Peters

School of Medicine

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Abstract

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.

Original language	English (US)
Article number	7138
Journal	Nature communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms8138
State	Published - Jul 7 2015

ASJC Scopus subject areas

General Physics and Astronomy
General Chemistry
General Biochemistry, Genetics and Molecular Biology

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10.1038/ncomms8138

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Schumacher, F. R., Schmit, S. L., Jiao, S., Edlund, C. K., Wang, H., Zhang, B., Hsu, L., Huang, S. C., Fischer, C. P., Harju, J. F., Idos, G. E., Lejbkowicz, F., Manion, F. J., McDonnell, K., McNeil, C. E., Melas, M., Rennert, H. S., Shi, W., Thomas, D. C., ... Peters, U. (2015). Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nature communications, 6, Article 7138. https://doi.org/10.1038/ncomms8138

Schumacher, FR, Schmit, SL, Jiao, S, Edlund, CK, Wang, H, Zhang, B, Hsu, L, Huang, SC, Fischer, CP, Harju, JF, Idos, GE, Lejbkowicz, F, Manion, FJ, McDonnell, K, McNeil, CE, Melas, M, Rennert, HS, Shi, W, Thomas, DC, Van Den Berg, DJ, Hutter, CM, Aragaki, AK, Butterbach, K, Caan, BJ, Carlson, CS, Chanock, SJ, Curtis, KR, Fuchs, CS, Gala, M, Giocannucci, EL, Gogarten, SM, Hayes, RB, Henderson, B, Hunter, DJ, Jackson, RD, Kolonel, LN, Kooperberg, C, Kury, S, Lacroix, A, Laurie, CC, Laurie, CA, Lemire, M, Levine, D, Ma, J, Makar, KW, Qu, C, Taverna, D, Ulrich, CM, Wu, K, Kono, S, West, DW, Berndt, SI, Bezieau, S, Brenner, H, Campbell, PT, Chan, AT, Chang-Claude, J, Coetzee, GA, Conti, DV, Duggan, D, Figueiredo, JC, Fortini, BK, Gallinger, SJ, Gauderman, WJ, Giles, G, Green, R, Haile, R, Harrison, TA, Hoffmeister, M, Hopper, JL, Hudson, TJ, Jacobs, E, Iwasaki, M, Jee, SH, Jenkins, M, Jia, WH, Joshi, A, Li, L, Lindor, NM, Matsuo, K, Moreno, V, Mukherjee, B, Newcomb, PA, Potter, JD, Raskin, L, Rennert, G, Rosse, S, Severi, G, Schoen, RE, Seminara, D, Shu, XO, Slattery, ML, Tsugane, S, White, E, Xiang, YB, Zanke, BW, Zheng, W, Le Marchand, L, Casey, G, Gruber, SB & Peters, U 2015, 'Genome-wide association study of colorectal cancer identifies six new susceptibility loci', Nature communications, vol. 6, 7138. https://doi.org/10.1038/ncomms8138

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title = "Genome-wide association study of colorectal cancer identifies six new susceptibility loci",

abstract = "Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.",

author = "Schumacher, {Fredrick R.} and Schmit, {Stephanie L.} and Shuo Jiao and Edlund, {Christopher K.} and Hansong Wang and Ben Zhang and Li Hsu and Huang, {Shu Chen} and Fischer, {Christopher P.} and Harju, {John F.} and Idos, {Gregory E.} and Flavio Lejbkowicz and Manion, {Frank J.} and Kevin McDonnell and McNeil, {Caroline E.} and Marilena Melas and Rennert, {Hedy S.} and Wei Shi and Thomas, {Duncan C.} and {Van Den Berg}, {David J.} and Hutter, {Carolyn M.} and Aragaki, {Aaron K.} and Katja Butterbach and Caan, {Bette J.} and Carlson, {Christopher S.} and Chanock, {Stephen J.} and Curtis, {Keith R.} and Fuchs, {Charles S.} and Manish Gala and Giocannucci, {Edward L.} and Gogarten, {Stephanie M.} and Hayes, {Richard B.} and Brian Henderson and Hunter, {David J.} and Jackson, {Rebecca D.} and Kolonel, {Laurence N.} and Charles Kooperberg and Sebastian Kury and Andrea Lacroix and Laurie, {Cathy C.} and Laurie, {Cecelia A.} and Mathiew Lemire and David Levine and Jing Ma and Makar, {Karen W.} and Conghui Qu and Darin Taverna and Ulrich, {Cornelia M.} and Kana Wu and Suminori Kono and West, {Dee W.} and Berndt, {Sonja I.} and Stephane Bezieau and Hermann Brenner and Campbell, {Peter T.} and Chan, {Andrew T.} and Jenny Chang-Claude and Coetzee, {Gerhard A.} and Conti, {David V.} and David Duggan and Figueiredo, {Jane C.} and Fortini, {Barbara K.} and Gallinger, {Steven J.} and Gauderman, {W. James} and Graham Giles and Roger Green and Robert Haile and Harrison, {Tabitha A.} and Michael Hoffmeister and Hopper, {John L.} and Hudson, {Thomas J.} and Eric Jacobs and Motoki Iwasaki and Jee, {Sun Ha} and Mark Jenkins and Jia, {Wei Hua} and Amit Joshi and Li Li and Lindor, {Noralene M.} and Keitaro Matsuo and Victor Moreno and Bhramar Mukherjee and Newcomb, {Polly A.} and Potter, {John D.} and Leon Raskin and Gad Rennert and Stephanie Rosse and Gianluca Severi and Schoen, {Robert E.} and Daniela Seminara and Shu, {Xiao Ou} and Slattery, {Martha L.} and Shoichiro Tsugane and Emily White and Xiang, {Yong Bing} and Zanke, {Brent W.} and Wei Zheng and {Le Marchand}, Loic and Graham Casey and Gruber, {Stephen B.} and Ulrike Peters",

note = "Publisher Copyright: {\textcopyright} 2015 Macmillan Publishers Limited.",

year = "2015",

month = jul,

day = "7",

doi = "10.1038/ncomms8138",

language = "English (US)",

volume = "6",

journal = "Nature communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Genome-wide association study of colorectal cancer identifies six new susceptibility loci

AU - Schumacher, Fredrick R.

AU - Schmit, Stephanie L.

AU - Jiao, Shuo

AU - Edlund, Christopher K.

AU - Wang, Hansong

AU - Zhang, Ben

AU - Hsu, Li

AU - Huang, Shu Chen

AU - Fischer, Christopher P.

AU - Harju, John F.

AU - Idos, Gregory E.

AU - Lejbkowicz, Flavio

AU - Manion, Frank J.

AU - McDonnell, Kevin

AU - McNeil, Caroline E.

AU - Melas, Marilena

AU - Rennert, Hedy S.

AU - Shi, Wei

AU - Thomas, Duncan C.

AU - Van Den Berg, David J.

AU - Hutter, Carolyn M.

AU - Aragaki, Aaron K.

AU - Butterbach, Katja

AU - Caan, Bette J.

AU - Carlson, Christopher S.

AU - Chanock, Stephen J.

AU - Curtis, Keith R.

AU - Fuchs, Charles S.

AU - Gala, Manish

AU - Giocannucci, Edward L.

AU - Gogarten, Stephanie M.

AU - Hayes, Richard B.

AU - Henderson, Brian

AU - Hunter, David J.

AU - Jackson, Rebecca D.

AU - Kolonel, Laurence N.

AU - Kooperberg, Charles

AU - Kury, Sebastian

AU - Lacroix, Andrea

AU - Laurie, Cathy C.

AU - Laurie, Cecelia A.

AU - Lemire, Mathiew

AU - Levine, David

AU - Ma, Jing

AU - Makar, Karen W.

AU - Qu, Conghui

AU - Taverna, Darin

AU - Ulrich, Cornelia M.

AU - Wu, Kana

AU - Kono, Suminori

AU - West, Dee W.

AU - Berndt, Sonja I.

AU - Bezieau, Stephane

AU - Brenner, Hermann

AU - Campbell, Peter T.

AU - Chan, Andrew T.

AU - Chang-Claude, Jenny

AU - Coetzee, Gerhard A.

AU - Conti, David V.

AU - Duggan, David

AU - Figueiredo, Jane C.

AU - Fortini, Barbara K.

AU - Gallinger, Steven J.

AU - Gauderman, W. James

AU - Giles, Graham

AU - Green, Roger

AU - Haile, Robert

AU - Harrison, Tabitha A.

AU - Hoffmeister, Michael

AU - Hopper, John L.

AU - Hudson, Thomas J.

AU - Jacobs, Eric

AU - Iwasaki, Motoki

AU - Jee, Sun Ha

AU - Jenkins, Mark

AU - Jia, Wei Hua

AU - Joshi, Amit

AU - Li, Li

AU - Lindor, Noralene M.

AU - Matsuo, Keitaro

AU - Moreno, Victor

AU - Mukherjee, Bhramar

AU - Newcomb, Polly A.

AU - Potter, John D.

AU - Raskin, Leon

AU - Rennert, Gad

AU - Rosse, Stephanie

AU - Severi, Gianluca

AU - Schoen, Robert E.

AU - Seminara, Daniela

AU - Shu, Xiao Ou

AU - Slattery, Martha L.

AU - Tsugane, Shoichiro

AU - White, Emily

AU - Xiang, Yong Bing

AU - Zanke, Brent W.

AU - Zheng, Wei

AU - Le Marchand, Loic

AU - Casey, Graham

AU - Gruber, Stephen B.

AU - Peters, Ulrike

PY - 2015/7/7

Y1 - 2015/7/7

N2 - Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.

AB - Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.

UR - http://www.scopus.com/inward/record.url?scp=84936745391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84936745391&partnerID=8YFLogxK

U2 - 10.1038/ncomms8138

DO - 10.1038/ncomms8138

M3 - Article

C2 - 26151821

AN - SCOPUS:84936745391

SN - 2041-1723

VL - 6

JO - Nature communications

JF - Nature communications

M1 - 7138

ER -

Genome-wide association study of colorectal cancer identifies six new susceptibility loci

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