Genome-wide association study identifies eight loci associated with blood pressure

Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D. Tobin, Murielle Bochud, Lachlan Coin, Samer S. Najjar, Jing Hua Zhao, Simon C. Heath, Susana Eyheramendy, Konstantinos Papadakis, Benjamin F. Voight, Laura J. Scott, Feng Zhang, Martin Farrall, Toshiko Tanaka, Chris Wallace, John C. Chambers, Kay Tee Khaw, Peter NilssonPim Van Der Harst, Silvia Polidoro, Diederick E. Grobbee, N. Charlotte Onland-Moret, Michiel L. Bots, Louise V. Wain, Katherine S. Elliott, Alexander Teumer, Jian'An Luan, Gavin Lucas, Johanna Kuusisto, Paul R. Burton, David Hadley, Wendy L. McArdle, Morris Brown, Anna Dominiczak, Stephen J. Newhouse, Nilesh J. Samani, John Webster, Eleftheria Zeggini, Jacques S. Beckmann, Sven Bergmann, Noha Lim, Kijoung Song, Peter Vollenweider, Gerard Waeber, Dawn M. Waterworth, Xin Yuan, Leif Groop, Marju Orho-Melander, Alessandra Allione, Alessandra Di Gregorio, Simonetta Guarrera, Salvatore Panico, Fulvio Ricceri, Valeria Romanazzi, Carlotta Sacerdote, Paolo Vineis, Inês Barroso, Manjinder S. Sandhu, Robert N. Luben, Gabriel J. Crawford, Pekka Jousilahti, Markus Perola, Michael Boehnke, Lori L. Bonnycastle, Francis S. Collins, Anne U. Jackson, Karen L. Mohlke, Heather M. Stringham, Timo T. Valle, Cristen J. Willer, Richard N. Bergman, Mario A. Morken, Angela Döring, Christian Gieger, Thomas Illig, Thomas Meitinger, Elin Org, Arne Pfeufer, H. Erich Wichmann, Sekar Kathiresan, Jaume Marrugat, Christopher J. O'Donnell, Stephen M. Schwartz, David S. Siscovick, Isaac Subirana, Nelson B. Freimer, Anna Liisa Hartikainen, Mark I. McCarthy, Paul F. O'Reilly, Leena Peltonen, Anneli Pouta, Paul E. De Jong, Harold Snieder, Wiek H. Van Gilst, Robert Clarke, Anuj Goel, Anders Hamsten, David Altshuler, Marjo Ritta Jarvelin, Paul Elliott, Edward Lakatta, Nita Forouhi, Nicholas J. Wareham, Ruth J F Loos, Panos Deloukas, Sheila A. Bingham, Diana Zelenika, David P. Strachan, Nicole Soranzo, Frances M. Williams, Guangju Zhai, Tim D. Spector, John F. Peden, Hugh Watkins, Luigi Ferrucci, Mark Caulfield, Patricia B. Munroe, Göran Berglund, Olle Melander, Guiseppe Matullo, Cuno S. Uiterwaal, Yvonne T. van der Schouw, Mattijs E. Numans, Florian Ernst, Georg Homuth, Uwe Völker, Roberto Eluosa, Markku Laakso, John M. Connell, Vincent Mooser, Veikko Salomaa, Jaakko Tuomilehto, Maris Laan, Gerjan Navis, Udo Seedorf, Ann Christine Syvänen, Giovanni Tognoni, Serena Sanna, Manuela Uda, Paul Scheet, David Schlessinger, Angelo Scuteri, Marcus Dörr, Stephan B. Felix, Thorsten Reffelmann, Roberto Lorbeer, Henry Völzke, Rainer Rettig, Pilar Galan, Serge Hercberg, Sheila A. Bingham, Jaspal S. Kooner, Stefania Bandinelli, Pierre Meneton, Gonçalo Abecasis, John R. Thompson, Carolina A. Braga Marcano, Beverley Barke, Richard Dobson, Johannie Gungadoo, Kate L. Lee, Abiodun Onipinla, I. Wallace, Mingzhan Xue, David G. Clayton, Hin Tak Leung, Sarah Nutland, Neil M. Walker, John A. Todd, Helen E. Stevens, David B. Dunger, Barry Widmer, Kate Downes, Lou R. Cardon, Dominic P. Kwiatkowski, Jeffrey C. Barrett, David Evans, Andrew P. Morris, Cecilia M. Lindgren, Nigel W. Rayner, Nicolas Timpson, Emily Lyons, Fredrik Vannberg, Adrian V S Hill, Yik Ying Teo, Kirk A. Rockett, Nick Craddock, Antony P. Attwood, Claire Bryan, Suzannah J. Bumpstead, Amy Chaney, Jilur Ghori, Rhian G. William, Sarah E. Hunt, Michael Inouye, Emma Keniry, Emma King, Ralph McGinnis, Simon Potter, Rathi Ravindrarajan, Pamela Whittaker, David Withers, David Bentley, Christopher J. Groves, Audrey Duncanson, Willem H. Ouwehand, James P. Boorman, Barbera Cant, Jennifer D. Jolley, Alexandra S. Knight, Kerstin Koch, Niall C. Taylor, Nicholas A. Watkins, Thilo Winzer, Peter S. Braund, Richard J. Dixon, Massimo Mangino, Suzanne Stevens, Peter Donnely, Dan Davidson, Jonathan L. Marchini, I. C A Spencer, Niall J. Cardin, Teresa Ferreira, Joanne Pereira-Gale, Ingeleif B. Hallgrimsdottir, Bryan N. Howie, Zhan Su, Damjan Vukcevic, Doug Easton, Ursula Everson, Judith M. Hussey, Elizabeth Meech, Christopher V. Prowse, Graham R. Walters, Richard W. Jones, Susan M. Ring, Marcus Prembey, Gerome Breen, David St. Clair, Sian Ceasar, Katherine Gordon-Smith, Lisa Jones, Elaine K. Green, Detelinea Grozeva, Marian L. Hamshere, Peter A. Holmans, Ian R. Jones, George Kirov, Valentina Moskovina, Ivan Nikolov, Michael C. O'Donovan, Michael J. Owen, Nick Craddock, David A. Collier, Amanda Elkin, Anne Farmer, Richard Williamson, Peter McGruffin, Allan H. Young, I. Nicol Ferrier, Stephen G. Ball, Anthony J. Balmforth, Jennifer H. Barrett, D. Timothy Bishop, Mark M. Iles, Azhar Maqbool, Nadira Yuldasheva, Alistair S. Hall, Francesca Bredin, Mark Tremelling, Miles Parkes, Hazel Drummond, Charles W. Lees, Elaine R. Nimmo, Jack Satsangi, Sheila A. Fisher, Cathryn M. Lewis, Clive M. Onnie, Nathalie J. Prescott, Christopher G. Mathew, Alastair Forbes, Jeremy Sanderson, Christopher Mathew, Jamie Barbour, M. Khalid Mohiuddin, Catherine E. Todhunter, John C. Mansfield, Tariq Ahmad, Fraser R. Cummings, Derek P. Jewell, Anne Barton, Ian N. Bruce, Hannah Donovan, Steve Eyre, Paul D. Gilbert, Samantha L. Hider, Anne M. Hinks, Sally L. John, Catherine Potter, Alan J. Silman, Deborah P M Symmons, Wendy Thomson, Jane Worthington, Timothy M. Frayling, Rachel M. Freathy, Hana Lango, John R B Perry, Michael N. Weedon, Andrew T. Hattersley, Beverley M. Shields, Graham A. Hitman, Mark Walker, Melanie Newport, Giorgio Sirugo, David Conway, Muminatou Jallow, Linda A. Bradbury, Jennifer L. Pointon, Matthew A. Brown, Claire Farrar, Paul Wordsworth, Jayne A. Franklyn, Joanne M. Heward, Matthew J. Simmonds, Stephen C L Cough, Sheila Seal, Michael R. Stratton, Nazneen Rahman, An Goris, Stephen J. Sawcer, Alastair Compston

Research output: Contribution to journalArticle

Abstract

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N 71,225 European ancestry, N 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10 24), CYP1A2 (P = 1 × 10 23), FGF5 (P = 1 × 10 21), SH2B3 (P = 3 × 10 18), MTHFR (P = 2 × 10 13), c10orf107 (P = 1 × 10 9), ZNF652 (P = 5 × 10 9) and PLCD3 (P = 1 × 10 8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)666-676
Number of pages11
JournalNature Genetics
Volume41
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

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Genome-Wide Association Study
Blood Pressure
Cardiovascular Diseases
Hypertension
Cytochrome P-450 CYP1A2
Computer Simulation
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Medicine(all)

Cite this

Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L., ... Compston, A. (2009). Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics, 41(6), 666-676. https://doi.org/10.1038/ng.361

Genome-wide association study identifies eight loci associated with blood pressure. / Newton-Cheh, Christopher; Johnson, Toby; Gateva, Vesela; Tobin, Martin D.; Bochud, Murielle; Coin, Lachlan; Najjar, Samer S.; Zhao, Jing Hua; Heath, Simon C.; Eyheramendy, Susana; Papadakis, Konstantinos; Voight, Benjamin F.; Scott, Laura J.; Zhang, Feng; Farrall, Martin; Tanaka, Toshiko; Wallace, Chris; Chambers, John C.; Khaw, Kay Tee; Nilsson, Peter; Van Der Harst, Pim; Polidoro, Silvia; Grobbee, Diederick E.; Onland-Moret, N. Charlotte; Bots, Michiel L.; Wain, Louise V.; Elliott, Katherine S.; Teumer, Alexander; Luan, Jian'An; Lucas, Gavin; Kuusisto, Johanna; Burton, Paul R.; Hadley, David; McArdle, Wendy L.; Brown, Morris; Dominiczak, Anna; Newhouse, Stephen J.; Samani, Nilesh J.; Webster, John; Zeggini, Eleftheria; Beckmann, Jacques S.; Bergmann, Sven; Lim, Noha; Song, Kijoung; Vollenweider, Peter; Waeber, Gerard; Waterworth, Dawn M.; Yuan, Xin; Groop, Leif; Orho-Melander, Marju; Allione, Alessandra; Di Gregorio, Alessandra; Guarrera, Simonetta; Panico, Salvatore; Ricceri, Fulvio; Romanazzi, Valeria; Sacerdote, Carlotta; Vineis, Paolo; Barroso, Inês; Sandhu, Manjinder S.; Luben, Robert N.; Crawford, Gabriel J.; Jousilahti, Pekka; Perola, Markus; Boehnke, Michael; Bonnycastle, Lori L.; Collins, Francis S.; Jackson, Anne U.; Mohlke, Karen L.; Stringham, Heather M.; Valle, Timo T.; Willer, Cristen J.; Bergman, Richard N.; Morken, Mario A.; Döring, Angela; Gieger, Christian; Illig, Thomas; Meitinger, Thomas; Org, Elin; Pfeufer, Arne; Wichmann, H. Erich; Kathiresan, Sekar; Marrugat, Jaume; O'Donnell, Christopher J.; Schwartz, Stephen M.; Siscovick, David S.; Subirana, Isaac; Freimer, Nelson B.; Hartikainen, Anna Liisa; McCarthy, Mark I.; O'Reilly, Paul F.; Peltonen, Leena; Pouta, Anneli; De Jong, Paul E.; Snieder, Harold; Van Gilst, Wiek H.; Clarke, Robert; Goel, Anuj; Hamsten, Anders; Altshuler, David; Jarvelin, Marjo Ritta; Elliott, Paul; Lakatta, Edward; Forouhi, Nita; Wareham, Nicholas J.; Loos, Ruth J F; Deloukas, Panos; Bingham, Sheila A.; Zelenika, Diana; Strachan, David P.; Soranzo, Nicole; Williams, Frances M.; Zhai, Guangju; Spector, Tim D.; Peden, John F.; Watkins, Hugh; Ferrucci, Luigi; Caulfield, Mark; Munroe, Patricia B.; Berglund, Göran; Melander, Olle; Matullo, Guiseppe; Uiterwaal, Cuno S.; van der Schouw, Yvonne T.; Numans, Mattijs E.; Ernst, Florian; Homuth, Georg; Völker, Uwe; Eluosa, Roberto; Laakso, Markku; Connell, John M.; Mooser, Vincent; Salomaa, Veikko; Tuomilehto, Jaakko; Laan, Maris; Navis, Gerjan; Seedorf, Udo; Syvänen, Ann Christine; Tognoni, Giovanni; Sanna, Serena; Uda, Manuela; Scheet, Paul; Schlessinger, David; Scuteri, Angelo; Dörr, Marcus; Felix, Stephan B.; Reffelmann, Thorsten; Lorbeer, Roberto; Völzke, Henry; Rettig, Rainer; Galan, Pilar; Hercberg, Serge; Bingham, Sheila A.; Kooner, Jaspal S.; Bandinelli, Stefania; Meneton, Pierre; Abecasis, Gonçalo; Thompson, John R.; Braga Marcano, Carolina A.; Barke, Beverley; Dobson, Richard; Gungadoo, Johannie; Lee, Kate L.; Onipinla, Abiodun; Wallace, I.; Xue, Mingzhan; Clayton, David G.; Leung, Hin Tak; Nutland, Sarah; Walker, Neil M.; Todd, John A.; Stevens, Helen E.; Dunger, David B.; Widmer, Barry; Downes, Kate; Cardon, Lou R.; Kwiatkowski, Dominic P.; Barrett, Jeffrey C.; Evans, David; Morris, Andrew P.; Lindgren, Cecilia M.; Rayner, Nigel W.; Timpson, Nicolas; Lyons, Emily; Vannberg, Fredrik; Hill, Adrian V S; Teo, Yik Ying; Rockett, Kirk A.; Craddock, Nick; Attwood, Antony P.; Bryan, Claire; Bumpstead, Suzannah J.; Chaney, Amy; Ghori, Jilur; William, Rhian G.; Hunt, Sarah E.; Inouye, Michael; Keniry, Emma; King, Emma; McGinnis, Ralph; Potter, Simon; Ravindrarajan, Rathi; Whittaker, Pamela; Withers, David; Bentley, David; Groves, Christopher J.; Duncanson, Audrey; Ouwehand, Willem H.; Boorman, James P.; Cant, Barbera; Jolley, Jennifer D.; Knight, Alexandra S.; Koch, Kerstin; Taylor, Niall C.; Watkins, Nicholas A.; Winzer, Thilo; Braund, Peter S.; Dixon, Richard J.; Mangino, Massimo; Stevens, Suzanne; Donnely, Peter; Davidson, Dan; Marchini, Jonathan L.; Spencer, I. C A; Cardin, Niall J.; Ferreira, Teresa; Pereira-Gale, Joanne; Hallgrimsdottir, Ingeleif B.; Howie, Bryan N.; Su, Zhan; Vukcevic, Damjan; Easton, Doug; Everson, Ursula; Hussey, Judith M.; Meech, Elizabeth; Prowse, Christopher V.; Walters, Graham R.; Jones, Richard W.; Ring, Susan M.; Prembey, Marcus; Breen, Gerome; St. Clair, David; Ceasar, Sian; Gordon-Smith, Katherine; Jones, Lisa; Green, Elaine K.; Grozeva, Detelinea; Hamshere, Marian L.; Holmans, Peter A.; Jones, Ian R.; Kirov, George; Moskovina, Valentina; Nikolov, Ivan; O'Donovan, Michael C.; Owen, Michael J.; Craddock, Nick; Collier, David A.; Elkin, Amanda; Farmer, Anne; Williamson, Richard; McGruffin, Peter; Young, Allan H.; Ferrier, I. Nicol; Ball, Stephen G.; Balmforth, Anthony J.; Barrett, Jennifer H.; Bishop, D. Timothy; Iles, Mark M.; Maqbool, Azhar; Yuldasheva, Nadira; Hall, Alistair S.; Bredin, Francesca; Tremelling, Mark; Parkes, Miles; Drummond, Hazel; Lees, Charles W.; Nimmo, Elaine R.; Satsangi, Jack; Fisher, Sheila A.; Lewis, Cathryn M.; Onnie, Clive M.; Prescott, Nathalie J.; Mathew, Christopher G.; Forbes, Alastair; Sanderson, Jeremy; Mathew, Christopher; Barbour, Jamie; Mohiuddin, M. Khalid; Todhunter, Catherine E.; Mansfield, John C.; Ahmad, Tariq; Cummings, Fraser R.; Jewell, Derek P.; Barton, Anne; Bruce, Ian N.; Donovan, Hannah; Eyre, Steve; Gilbert, Paul D.; Hider, Samantha L.; Hinks, Anne M.; John, Sally L.; Potter, Catherine; Silman, Alan J.; Symmons, Deborah P M; Thomson, Wendy; Worthington, Jane; Frayling, Timothy M.; Freathy, Rachel M.; Lango, Hana; Perry, John R B; Weedon, Michael N.; Hattersley, Andrew T.; Shields, Beverley M.; Hitman, Graham A.; Walker, Mark; Newport, Melanie; Sirugo, Giorgio; Conway, David; Jallow, Muminatou; Bradbury, Linda A.; Pointon, Jennifer L.; Brown, Matthew A.; Farrar, Claire; Wordsworth, Paul; Franklyn, Jayne A.; Heward, Joanne M.; Simmonds, Matthew J.; Cough, Stephen C L; Seal, Sheila; Stratton, Michael R.; Rahman, Nazneen; Goris, An; Sawcer, Stephen J.; Compston, Alastair.

In: Nature Genetics, Vol. 41, No. 6, 06.2009, p. 666-676.

Research output: Contribution to journalArticle

Newton-Cheh, C, Johnson, T, Gateva, V, Tobin, MD, Bochud, M, Coin, L, Najjar, SS, Zhao, JH, Heath, SC, Eyheramendy, S, Papadakis, K, Voight, BF, Scott, LJ, Zhang, F, Farrall, M, Tanaka, T, Wallace, C, Chambers, JC, Khaw, KT, Nilsson, P, Van Der Harst, P, Polidoro, S, Grobbee, DE, Onland-Moret, NC, Bots, ML, Wain, LV, Elliott, KS, Teumer, A, Luan, JA, Lucas, G, Kuusisto, J, Burton, PR, Hadley, D, McArdle, WL, Brown, M, Dominiczak, A, Newhouse, SJ, Samani, NJ, Webster, J, Zeggini, E, Beckmann, JS, Bergmann, S, Lim, N, Song, K, Vollenweider, P, Waeber, G, Waterworth, DM, Yuan, X, Groop, L, Orho-Melander, M, Allione, A, Di Gregorio, A, Guarrera, S, Panico, S, Ricceri, F, Romanazzi, V, Sacerdote, C, Vineis, P, Barroso, I, Sandhu, MS, Luben, RN, Crawford, GJ, Jousilahti, P, Perola, M, Boehnke, M, Bonnycastle, LL, Collins, FS, Jackson, AU, Mohlke, KL, Stringham, HM, Valle, TT, Willer, CJ, Bergman, RN, Morken, MA, Döring, A, Gieger, C, Illig, T, Meitinger, T, Org, E, Pfeufer, A, Wichmann, HE, Kathiresan, S, Marrugat, J, O'Donnell, CJ, Schwartz, SM, Siscovick, DS, Subirana, I, Freimer, NB, Hartikainen, AL, McCarthy, MI, O'Reilly, PF, Peltonen, L, Pouta, A, De Jong, PE, Snieder, H, Van Gilst, WH, Clarke, R, Goel, A, Hamsten, A, Altshuler, D, Jarvelin, MR, Elliott, P, Lakatta, E, Forouhi, N, Wareham, NJ, Loos, RJF, Deloukas, P, Bingham, SA, Zelenika, D, Strachan, DP, Soranzo, N, Williams, FM, Zhai, G, Spector, TD, Peden, JF, Watkins, H, Ferrucci, L, Caulfield, M, Munroe, PB, Berglund, G, Melander, O, Matullo, G, Uiterwaal, CS, van der Schouw, YT, Numans, ME, Ernst, F, Homuth, G, Völker, U, Eluosa, R, Laakso, M, Connell, JM, Mooser, V, Salomaa, V, Tuomilehto, J, Laan, M, Navis, G, Seedorf, U, Syvänen, AC, Tognoni, G, Sanna, S, Uda, M, Scheet, P, Schlessinger, D, Scuteri, A, Dörr, M, Felix, SB, Reffelmann, T, Lorbeer, R, Völzke, H, Rettig, R, Galan, P, Hercberg, S, Bingham, SA, Kooner, JS, Bandinelli, S, Meneton, P, Abecasis, G, Thompson, JR, Braga Marcano, CA, Barke, B, Dobson, R, Gungadoo, J, Lee, KL, Onipinla, A, Wallace, I, Xue, M, Clayton, DG, Leung, HT, Nutland, S, Walker, NM, Todd, JA, Stevens, HE, Dunger, DB, Widmer, B, Downes, K, Cardon, LR, Kwiatkowski, DP, Barrett, JC, Evans, D, Morris, AP, Lindgren, CM, Rayner, NW, Timpson, N, Lyons, E, Vannberg, F, Hill, AVS, Teo, YY, Rockett, KA, Craddock, N, Attwood, AP, Bryan, C, Bumpstead, SJ, Chaney, A, Ghori, J, William, RG, Hunt, SE, Inouye, M, Keniry, E, King, E, McGinnis, R, Potter, S, Ravindrarajan, R, Whittaker, P, Withers, D, Bentley, D, Groves, CJ, Duncanson, A, Ouwehand, WH, Boorman, JP, Cant, B, Jolley, JD, Knight, AS, Koch, K, Taylor, NC, Watkins, NA, Winzer, T, Braund, PS, Dixon, RJ, Mangino, M, Stevens, S, Donnely, P, Davidson, D, Marchini, JL, Spencer, ICA, Cardin, NJ, Ferreira, T, Pereira-Gale, J, Hallgrimsdottir, IB, Howie, BN, Su, Z, Vukcevic, D, Easton, D, Everson, U, Hussey, JM, Meech, E, Prowse, CV, Walters, GR, Jones, RW, Ring, SM, Prembey, M, Breen, G, St. Clair, D, Ceasar, S, Gordon-Smith, K, Jones, L, Green, EK, Grozeva, D, Hamshere, ML, Holmans, PA, Jones, IR, Kirov, G, Moskovina, V, Nikolov, I, O'Donovan, MC, Owen, MJ, Craddock, N, Collier, DA, Elkin, A, Farmer, A, Williamson, R, McGruffin, P, Young, AH, Ferrier, IN, Ball, SG, Balmforth, AJ, Barrett, JH, Bishop, DT, Iles, MM, Maqbool, A, Yuldasheva, N, Hall, AS, Bredin, F, Tremelling, M, Parkes, M, Drummond, H, Lees, CW, Nimmo, ER, Satsangi, J, Fisher, SA, Lewis, CM, Onnie, CM, Prescott, NJ, Mathew, CG, Forbes, A, Sanderson, J, Mathew, C, Barbour, J, Mohiuddin, MK, Todhunter, CE, Mansfield, JC, Ahmad, T, Cummings, FR, Jewell, DP, Barton, A, Bruce, IN, Donovan, H, Eyre, S, Gilbert, PD, Hider, SL, Hinks, AM, John, SL, Potter, C, Silman, AJ, Symmons, DPM, Thomson, W, Worthington, J, Frayling, TM, Freathy, RM, Lango, H, Perry, JRB, Weedon, MN, Hattersley, AT, Shields, BM, Hitman, GA, Walker, M, Newport, M, Sirugo, G, Conway, D, Jallow, M, Bradbury, LA, Pointon, JL, Brown, MA, Farrar, C, Wordsworth, P, Franklyn, JA, Heward, JM, Simmonds, MJ, Cough, SCL, Seal, S, Stratton, MR, Rahman, N, Goris, A, Sawcer, SJ & Compston, A 2009, 'Genome-wide association study identifies eight loci associated with blood pressure', Nature Genetics, vol. 41, no. 6, pp. 666-676. https://doi.org/10.1038/ng.361
Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L et al. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics. 2009 Jun;41(6):666-676. https://doi.org/10.1038/ng.361
Newton-Cheh, Christopher ; Johnson, Toby ; Gateva, Vesela ; Tobin, Martin D. ; Bochud, Murielle ; Coin, Lachlan ; Najjar, Samer S. ; Zhao, Jing Hua ; Heath, Simon C. ; Eyheramendy, Susana ; Papadakis, Konstantinos ; Voight, Benjamin F. ; Scott, Laura J. ; Zhang, Feng ; Farrall, Martin ; Tanaka, Toshiko ; Wallace, Chris ; Chambers, John C. ; Khaw, Kay Tee ; Nilsson, Peter ; Van Der Harst, Pim ; Polidoro, Silvia ; Grobbee, Diederick E. ; Onland-Moret, N. Charlotte ; Bots, Michiel L. ; Wain, Louise V. ; Elliott, Katherine S. ; Teumer, Alexander ; Luan, Jian'An ; Lucas, Gavin ; Kuusisto, Johanna ; Burton, Paul R. ; Hadley, David ; McArdle, Wendy L. ; Brown, Morris ; Dominiczak, Anna ; Newhouse, Stephen J. ; Samani, Nilesh J. ; Webster, John ; Zeggini, Eleftheria ; Beckmann, Jacques S. ; Bergmann, Sven ; Lim, Noha ; Song, Kijoung ; Vollenweider, Peter ; Waeber, Gerard ; Waterworth, Dawn M. ; Yuan, Xin ; Groop, Leif ; Orho-Melander, Marju ; Allione, Alessandra ; Di Gregorio, Alessandra ; Guarrera, Simonetta ; Panico, Salvatore ; Ricceri, Fulvio ; Romanazzi, Valeria ; Sacerdote, Carlotta ; Vineis, Paolo ; Barroso, Inês ; Sandhu, Manjinder S. ; Luben, Robert N. ; Crawford, Gabriel J. ; Jousilahti, Pekka ; Perola, Markus ; Boehnke, Michael ; Bonnycastle, Lori L. ; Collins, Francis S. ; Jackson, Anne U. ; Mohlke, Karen L. ; Stringham, Heather M. ; Valle, Timo T. ; Willer, Cristen J. ; Bergman, Richard N. ; Morken, Mario A. ; Döring, Angela ; Gieger, Christian ; Illig, Thomas ; Meitinger, Thomas ; Org, Elin ; Pfeufer, Arne ; Wichmann, H. Erich ; Kathiresan, Sekar ; Marrugat, Jaume ; O'Donnell, Christopher J. ; Schwartz, Stephen M. ; Siscovick, David S. ; Subirana, Isaac ; Freimer, Nelson B. ; Hartikainen, Anna Liisa ; McCarthy, Mark I. ; O'Reilly, Paul F. ; Peltonen, Leena ; Pouta, Anneli ; De Jong, Paul E. ; Snieder, Harold ; Van Gilst, Wiek H. ; Clarke, Robert ; Goel, Anuj ; Hamsten, Anders ; Altshuler, David ; Jarvelin, Marjo Ritta ; Elliott, Paul ; Lakatta, Edward ; Forouhi, Nita ; Wareham, Nicholas J. ; Loos, Ruth J F ; Deloukas, Panos ; Bingham, Sheila A. ; Zelenika, Diana ; Strachan, David P. ; Soranzo, Nicole ; Williams, Frances M. ; Zhai, Guangju ; Spector, Tim D. ; Peden, John F. ; Watkins, Hugh ; Ferrucci, Luigi ; Caulfield, Mark ; Munroe, Patricia B. ; Berglund, Göran ; Melander, Olle ; Matullo, Guiseppe ; Uiterwaal, Cuno S. ; van der Schouw, Yvonne T. ; Numans, Mattijs E. ; Ernst, Florian ; Homuth, Georg ; Völker, Uwe ; Eluosa, Roberto ; Laakso, Markku ; Connell, John M. ; Mooser, Vincent ; Salomaa, Veikko ; Tuomilehto, Jaakko ; Laan, Maris ; Navis, Gerjan ; Seedorf, Udo ; Syvänen, Ann Christine ; Tognoni, Giovanni ; Sanna, Serena ; Uda, Manuela ; Scheet, Paul ; Schlessinger, David ; Scuteri, Angelo ; Dörr, Marcus ; Felix, Stephan B. ; Reffelmann, Thorsten ; Lorbeer, Roberto ; Völzke, Henry ; Rettig, Rainer ; Galan, Pilar ; Hercberg, Serge ; Bingham, Sheila A. ; Kooner, Jaspal S. ; Bandinelli, Stefania ; Meneton, Pierre ; Abecasis, Gonçalo ; Thompson, John R. ; Braga Marcano, Carolina A. ; Barke, Beverley ; Dobson, Richard ; Gungadoo, Johannie ; Lee, Kate L. ; Onipinla, Abiodun ; Wallace, I. ; Xue, Mingzhan ; Clayton, David G. ; Leung, Hin Tak ; Nutland, Sarah ; Walker, Neil M. ; Todd, John A. ; Stevens, Helen E. ; Dunger, David B. ; Widmer, Barry ; Downes, Kate ; Cardon, Lou R. ; Kwiatkowski, Dominic P. ; Barrett, Jeffrey C. ; Evans, David ; Morris, Andrew P. ; Lindgren, Cecilia M. ; Rayner, Nigel W. ; Timpson, Nicolas ; Lyons, Emily ; Vannberg, Fredrik ; Hill, Adrian V S ; Teo, Yik Ying ; Rockett, Kirk A. ; Craddock, Nick ; Attwood, Antony P. ; Bryan, Claire ; Bumpstead, Suzannah J. ; Chaney, Amy ; Ghori, Jilur ; William, Rhian G. ; Hunt, Sarah E. ; Inouye, Michael ; Keniry, Emma ; King, Emma ; McGinnis, Ralph ; Potter, Simon ; Ravindrarajan, Rathi ; Whittaker, Pamela ; Withers, David ; Bentley, David ; Groves, Christopher J. ; Duncanson, Audrey ; Ouwehand, Willem H. ; Boorman, James P. ; Cant, Barbera ; Jolley, Jennifer D. ; Knight, Alexandra S. ; Koch, Kerstin ; Taylor, Niall C. ; Watkins, Nicholas A. ; Winzer, Thilo ; Braund, Peter S. ; Dixon, Richard J. ; Mangino, Massimo ; Stevens, Suzanne ; Donnely, Peter ; Davidson, Dan ; Marchini, Jonathan L. ; Spencer, I. C A ; Cardin, Niall J. ; Ferreira, Teresa ; Pereira-Gale, Joanne ; Hallgrimsdottir, Ingeleif B. ; Howie, Bryan N. ; Su, Zhan ; Vukcevic, Damjan ; Easton, Doug ; Everson, Ursula ; Hussey, Judith M. ; Meech, Elizabeth ; Prowse, Christopher V. ; Walters, Graham R. ; Jones, Richard W. ; Ring, Susan M. ; Prembey, Marcus ; Breen, Gerome ; St. Clair, David ; Ceasar, Sian ; Gordon-Smith, Katherine ; Jones, Lisa ; Green, Elaine K. ; Grozeva, Detelinea ; Hamshere, Marian L. ; Holmans, Peter A. ; Jones, Ian R. ; Kirov, George ; Moskovina, Valentina ; Nikolov, Ivan ; O'Donovan, Michael C. ; Owen, Michael J. ; Craddock, Nick ; Collier, David A. ; Elkin, Amanda ; Farmer, Anne ; Williamson, Richard ; McGruffin, Peter ; Young, Allan H. ; Ferrier, I. Nicol ; Ball, Stephen G. ; Balmforth, Anthony J. ; Barrett, Jennifer H. ; Bishop, D. Timothy ; Iles, Mark M. ; Maqbool, Azhar ; Yuldasheva, Nadira ; Hall, Alistair S. ; Bredin, Francesca ; Tremelling, Mark ; Parkes, Miles ; Drummond, Hazel ; Lees, Charles W. ; Nimmo, Elaine R. ; Satsangi, Jack ; Fisher, Sheila A. ; Lewis, Cathryn M. ; Onnie, Clive M. ; Prescott, Nathalie J. ; Mathew, Christopher G. ; Forbes, Alastair ; Sanderson, Jeremy ; Mathew, Christopher ; Barbour, Jamie ; Mohiuddin, M. Khalid ; Todhunter, Catherine E. ; Mansfield, John C. ; Ahmad, Tariq ; Cummings, Fraser R. ; Jewell, Derek P. ; Barton, Anne ; Bruce, Ian N. ; Donovan, Hannah ; Eyre, Steve ; Gilbert, Paul D. ; Hider, Samantha L. ; Hinks, Anne M. ; John, Sally L. ; Potter, Catherine ; Silman, Alan J. ; Symmons, Deborah P M ; Thomson, Wendy ; Worthington, Jane ; Frayling, Timothy M. ; Freathy, Rachel M. ; Lango, Hana ; Perry, John R B ; Weedon, Michael N. ; Hattersley, Andrew T. ; Shields, Beverley M. ; Hitman, Graham A. ; Walker, Mark ; Newport, Melanie ; Sirugo, Giorgio ; Conway, David ; Jallow, Muminatou ; Bradbury, Linda A. ; Pointon, Jennifer L. ; Brown, Matthew A. ; Farrar, Claire ; Wordsworth, Paul ; Franklyn, Jayne A. ; Heward, Joanne M. ; Simmonds, Matthew J. ; Cough, Stephen C L ; Seal, Sheila ; Stratton, Michael R. ; Rahman, Nazneen ; Goris, An ; Sawcer, Stephen J. ; Compston, Alastair. / Genome-wide association study identifies eight loci associated with blood pressure. In: Nature Genetics. 2009 ; Vol. 41, No. 6. pp. 666-676.
@article{6ed947727cca4f88ad0f3ee8e94d8cbe,
title = "Genome-wide association study identifies eight loci associated with blood pressure",
abstract = "Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N 71,225 European ancestry, N 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10 24), CYP1A2 (P = 1 × 10 23), FGF5 (P = 1 × 10 21), SH2B3 (P = 3 × 10 18), MTHFR (P = 2 × 10 13), c10orf107 (P = 1 × 10 9), ZNF652 (P = 5 × 10 9) and PLCD3 (P = 1 × 10 8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.",
author = "Christopher Newton-Cheh and Toby Johnson and Vesela Gateva and Tobin, {Martin D.} and Murielle Bochud and Lachlan Coin and Najjar, {Samer S.} and Zhao, {Jing Hua} and Heath, {Simon C.} and Susana Eyheramendy and Konstantinos Papadakis and Voight, {Benjamin F.} and Scott, {Laura J.} and Feng Zhang and Martin Farrall and Toshiko Tanaka and Chris Wallace and Chambers, {John C.} and Khaw, {Kay Tee} and Peter Nilsson and {Van Der Harst}, Pim and Silvia Polidoro and Grobbee, {Diederick E.} and Onland-Moret, {N. Charlotte} and Bots, {Michiel L.} and Wain, {Louise V.} and Elliott, {Katherine S.} and Alexander Teumer and Jian'An Luan and Gavin Lucas and Johanna Kuusisto and Burton, {Paul R.} and David Hadley and McArdle, {Wendy L.} and Morris Brown and Anna Dominiczak and Newhouse, {Stephen J.} and Samani, {Nilesh J.} and John Webster and Eleftheria Zeggini and Beckmann, {Jacques S.} and Sven Bergmann and Noha Lim and Kijoung Song and Peter Vollenweider and Gerard Waeber and Waterworth, {Dawn M.} and Xin Yuan and Leif Groop and Marju Orho-Melander and Alessandra Allione and {Di Gregorio}, Alessandra and Simonetta Guarrera and Salvatore Panico and Fulvio Ricceri and Valeria Romanazzi and Carlotta Sacerdote and Paolo Vineis and In{\^e}s Barroso and Sandhu, {Manjinder S.} and Luben, {Robert N.} and Crawford, {Gabriel J.} and Pekka Jousilahti and Markus Perola and Michael Boehnke and Bonnycastle, {Lori L.} and Collins, {Francis S.} and Jackson, {Anne U.} and Mohlke, {Karen L.} and Stringham, {Heather M.} and Valle, {Timo T.} and Willer, {Cristen J.} and Bergman, {Richard N.} and Morken, {Mario A.} and Angela D{\"o}ring and Christian Gieger and Thomas Illig and Thomas Meitinger and Elin Org and Arne Pfeufer and Wichmann, {H. Erich} and Sekar Kathiresan and Jaume Marrugat and O'Donnell, {Christopher J.} and Schwartz, {Stephen M.} and Siscovick, {David S.} and Isaac Subirana and Freimer, {Nelson B.} and Hartikainen, {Anna Liisa} and McCarthy, {Mark I.} and O'Reilly, {Paul F.} and Leena Peltonen and Anneli Pouta and {De Jong}, {Paul E.} and Harold Snieder and {Van Gilst}, {Wiek H.} and Robert Clarke and Anuj Goel and Anders Hamsten and David Altshuler and Jarvelin, {Marjo Ritta} and Paul Elliott and Edward Lakatta and Nita Forouhi and Wareham, {Nicholas J.} and Loos, {Ruth J F} and Panos Deloukas and Bingham, {Sheila A.} and Diana Zelenika and Strachan, {David P.} and Nicole Soranzo and Williams, {Frances M.} and Guangju Zhai and Spector, {Tim D.} and Peden, {John F.} and Hugh Watkins and Luigi Ferrucci and Mark Caulfield and Munroe, {Patricia B.} and G{\"o}ran Berglund and Olle Melander and Guiseppe Matullo and Uiterwaal, {Cuno S.} and {van der Schouw}, {Yvonne T.} and Numans, {Mattijs E.} and Florian Ernst and Georg Homuth and Uwe V{\"o}lker and Roberto Eluosa and Markku Laakso and Connell, {John M.} and Vincent Mooser and Veikko Salomaa and Jaakko Tuomilehto and Maris Laan and Gerjan Navis and Udo Seedorf and Syv{\"a}nen, {Ann Christine} and Giovanni Tognoni and Serena Sanna and Manuela Uda and Paul Scheet and David Schlessinger and Angelo Scuteri and Marcus D{\"o}rr and Felix, {Stephan B.} and Thorsten Reffelmann and Roberto Lorbeer and Henry V{\"o}lzke and Rainer Rettig and Pilar Galan and Serge Hercberg and Bingham, {Sheila A.} and Kooner, {Jaspal S.} and Stefania Bandinelli and Pierre Meneton and Gon{\cc}alo Abecasis and Thompson, {John R.} and {Braga Marcano}, {Carolina A.} and Beverley Barke and Richard Dobson and Johannie Gungadoo and Lee, {Kate L.} and Abiodun Onipinla and I. Wallace and Mingzhan Xue and Clayton, {David G.} and Leung, {Hin Tak} and Sarah Nutland and Walker, {Neil M.} and Todd, {John A.} and Stevens, {Helen E.} and Dunger, {David B.} and Barry Widmer and Kate Downes and Cardon, {Lou R.} and Kwiatkowski, {Dominic P.} and Barrett, {Jeffrey C.} and David Evans and Morris, {Andrew P.} and Lindgren, {Cecilia M.} and Rayner, {Nigel W.} and Nicolas Timpson and Emily Lyons and Fredrik Vannberg and Hill, {Adrian V S} and Teo, {Yik Ying} and Rockett, {Kirk A.} and Nick Craddock and Attwood, {Antony P.} and Claire Bryan and Bumpstead, {Suzannah J.} and Amy Chaney and Jilur Ghori and William, {Rhian G.} and Hunt, {Sarah E.} and Michael Inouye and Emma Keniry and Emma King and Ralph McGinnis and Simon Potter and Rathi Ravindrarajan and Pamela Whittaker and David Withers and David Bentley and Groves, {Christopher J.} and Audrey Duncanson and Ouwehand, {Willem H.} and Boorman, {James P.} and Barbera Cant and Jolley, {Jennifer D.} and Knight, {Alexandra S.} and Kerstin Koch and Taylor, {Niall C.} and Watkins, {Nicholas A.} and Thilo Winzer and Braund, {Peter S.} and Dixon, {Richard J.} and Massimo Mangino and Suzanne Stevens and Peter Donnely and Dan Davidson and Marchini, {Jonathan L.} and Spencer, {I. C A} and Cardin, {Niall J.} and Teresa Ferreira and Joanne Pereira-Gale and Hallgrimsdottir, {Ingeleif B.} and Howie, {Bryan N.} and Zhan Su and Damjan Vukcevic and Doug Easton and Ursula Everson and Hussey, {Judith M.} and Elizabeth Meech and Prowse, {Christopher V.} and Walters, {Graham R.} and Jones, {Richard W.} and Ring, {Susan M.} and Marcus Prembey and Gerome Breen and {St. Clair}, David and Sian Ceasar and Katherine Gordon-Smith and Lisa Jones and Green, {Elaine K.} and Detelinea Grozeva and Hamshere, {Marian L.} and Holmans, {Peter A.} and Jones, {Ian R.} and George Kirov and Valentina Moskovina and Ivan Nikolov and O'Donovan, {Michael C.} and Owen, {Michael J.} and Nick Craddock and Collier, {David A.} and Amanda Elkin and Anne Farmer and Richard Williamson and Peter McGruffin and Young, {Allan H.} and Ferrier, {I. Nicol} and Ball, {Stephen G.} and Balmforth, {Anthony J.} and Barrett, {Jennifer H.} and Bishop, {D. Timothy} and Iles, {Mark M.} and Azhar Maqbool and Nadira Yuldasheva and Hall, {Alistair S.} and Francesca Bredin and Mark Tremelling and Miles Parkes and Hazel Drummond and Lees, {Charles W.} and Nimmo, {Elaine R.} and Jack Satsangi and Fisher, {Sheila A.} and Lewis, {Cathryn M.} and Onnie, {Clive M.} and Prescott, {Nathalie J.} and Mathew, {Christopher G.} and Alastair Forbes and Jeremy Sanderson and Christopher Mathew and Jamie Barbour and Mohiuddin, {M. Khalid} and Todhunter, {Catherine E.} and Mansfield, {John C.} and Tariq Ahmad and Cummings, {Fraser R.} and Jewell, {Derek P.} and Anne Barton and Bruce, {Ian N.} and Hannah Donovan and Steve Eyre and Gilbert, {Paul D.} and Hider, {Samantha L.} and Hinks, {Anne M.} and John, {Sally L.} and Catherine Potter and Silman, {Alan J.} and Symmons, {Deborah P M} and Wendy Thomson and Jane Worthington and Frayling, {Timothy M.} and Freathy, {Rachel M.} and Hana Lango and Perry, {John R B} and Weedon, {Michael N.} and Hattersley, {Andrew T.} and Shields, {Beverley M.} and Hitman, {Graham A.} and Mark Walker and Melanie Newport and Giorgio Sirugo and David Conway and Muminatou Jallow and Bradbury, {Linda A.} and Pointon, {Jennifer L.} and Brown, {Matthew A.} and Claire Farrar and Paul Wordsworth and Franklyn, {Jayne A.} and Heward, {Joanne M.} and Simmonds, {Matthew J.} and Cough, {Stephen C L} and Sheila Seal and Stratton, {Michael R.} and Nazneen Rahman and An Goris and Sawcer, {Stephen J.} and Alastair Compston",
year = "2009",
month = "6",
doi = "10.1038/ng.361",
language = "English (US)",
volume = "41",
pages = "666--676",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Genome-wide association study identifies eight loci associated with blood pressure

AU - Newton-Cheh, Christopher

AU - Johnson, Toby

AU - Gateva, Vesela

AU - Tobin, Martin D.

AU - Bochud, Murielle

AU - Coin, Lachlan

AU - Najjar, Samer S.

AU - Zhao, Jing Hua

AU - Heath, Simon C.

AU - Eyheramendy, Susana

AU - Papadakis, Konstantinos

AU - Voight, Benjamin F.

AU - Scott, Laura J.

AU - Zhang, Feng

AU - Farrall, Martin

AU - Tanaka, Toshiko

AU - Wallace, Chris

AU - Chambers, John C.

AU - Khaw, Kay Tee

AU - Nilsson, Peter

AU - Van Der Harst, Pim

AU - Polidoro, Silvia

AU - Grobbee, Diederick E.

AU - Onland-Moret, N. Charlotte

AU - Bots, Michiel L.

AU - Wain, Louise V.

AU - Elliott, Katherine S.

AU - Teumer, Alexander

AU - Luan, Jian'An

AU - Lucas, Gavin

AU - Kuusisto, Johanna

AU - Burton, Paul R.

AU - Hadley, David

AU - McArdle, Wendy L.

AU - Brown, Morris

AU - Dominiczak, Anna

AU - Newhouse, Stephen J.

AU - Samani, Nilesh J.

AU - Webster, John

AU - Zeggini, Eleftheria

AU - Beckmann, Jacques S.

AU - Bergmann, Sven

AU - Lim, Noha

AU - Song, Kijoung

AU - Vollenweider, Peter

AU - Waeber, Gerard

AU - Waterworth, Dawn M.

AU - Yuan, Xin

AU - Groop, Leif

AU - Orho-Melander, Marju

AU - Allione, Alessandra

AU - Di Gregorio, Alessandra

AU - Guarrera, Simonetta

AU - Panico, Salvatore

AU - Ricceri, Fulvio

AU - Romanazzi, Valeria

AU - Sacerdote, Carlotta

AU - Vineis, Paolo

AU - Barroso, Inês

AU - Sandhu, Manjinder S.

AU - Luben, Robert N.

AU - Crawford, Gabriel J.

AU - Jousilahti, Pekka

AU - Perola, Markus

AU - Boehnke, Michael

AU - Bonnycastle, Lori L.

AU - Collins, Francis S.

AU - Jackson, Anne U.

AU - Mohlke, Karen L.

AU - Stringham, Heather M.

AU - Valle, Timo T.

AU - Willer, Cristen J.

AU - Bergman, Richard N.

AU - Morken, Mario A.

AU - Döring, Angela

AU - Gieger, Christian

AU - Illig, Thomas

AU - Meitinger, Thomas

AU - Org, Elin

AU - Pfeufer, Arne

AU - Wichmann, H. Erich

AU - Kathiresan, Sekar

AU - Marrugat, Jaume

AU - O'Donnell, Christopher J.

AU - Schwartz, Stephen M.

AU - Siscovick, David S.

AU - Subirana, Isaac

AU - Freimer, Nelson B.

AU - Hartikainen, Anna Liisa

AU - McCarthy, Mark I.

AU - O'Reilly, Paul F.

AU - Peltonen, Leena

AU - Pouta, Anneli

AU - De Jong, Paul E.

AU - Snieder, Harold

AU - Van Gilst, Wiek H.

AU - Clarke, Robert

AU - Goel, Anuj

AU - Hamsten, Anders

AU - Altshuler, David

AU - Jarvelin, Marjo Ritta

AU - Elliott, Paul

AU - Lakatta, Edward

AU - Forouhi, Nita

AU - Wareham, Nicholas J.

AU - Loos, Ruth J F

AU - Deloukas, Panos

AU - Bingham, Sheila A.

AU - Zelenika, Diana

AU - Strachan, David P.

AU - Soranzo, Nicole

AU - Williams, Frances M.

AU - Zhai, Guangju

AU - Spector, Tim D.

AU - Peden, John F.

AU - Watkins, Hugh

AU - Ferrucci, Luigi

AU - Caulfield, Mark

AU - Munroe, Patricia B.

AU - Berglund, Göran

AU - Melander, Olle

AU - Matullo, Guiseppe

AU - Uiterwaal, Cuno S.

AU - van der Schouw, Yvonne T.

AU - Numans, Mattijs E.

AU - Ernst, Florian

AU - Homuth, Georg

AU - Völker, Uwe

AU - Eluosa, Roberto

AU - Laakso, Markku

AU - Connell, John M.

AU - Mooser, Vincent

AU - Salomaa, Veikko

AU - Tuomilehto, Jaakko

AU - Laan, Maris

AU - Navis, Gerjan

AU - Seedorf, Udo

AU - Syvänen, Ann Christine

AU - Tognoni, Giovanni

AU - Sanna, Serena

AU - Uda, Manuela

AU - Scheet, Paul

AU - Schlessinger, David

AU - Scuteri, Angelo

AU - Dörr, Marcus

AU - Felix, Stephan B.

AU - Reffelmann, Thorsten

AU - Lorbeer, Roberto

AU - Völzke, Henry

AU - Rettig, Rainer

AU - Galan, Pilar

AU - Hercberg, Serge

AU - Bingham, Sheila A.

AU - Kooner, Jaspal S.

AU - Bandinelli, Stefania

AU - Meneton, Pierre

AU - Abecasis, Gonçalo

AU - Thompson, John R.

AU - Braga Marcano, Carolina A.

AU - Barke, Beverley

AU - Dobson, Richard

AU - Gungadoo, Johannie

AU - Lee, Kate L.

AU - Onipinla, Abiodun

AU - Wallace, I.

AU - Xue, Mingzhan

AU - Clayton, David G.

AU - Leung, Hin Tak

AU - Nutland, Sarah

AU - Walker, Neil M.

AU - Todd, John A.

AU - Stevens, Helen E.

AU - Dunger, David B.

AU - Widmer, Barry

AU - Downes, Kate

AU - Cardon, Lou R.

AU - Kwiatkowski, Dominic P.

AU - Barrett, Jeffrey C.

AU - Evans, David

AU - Morris, Andrew P.

AU - Lindgren, Cecilia M.

AU - Rayner, Nigel W.

AU - Timpson, Nicolas

AU - Lyons, Emily

AU - Vannberg, Fredrik

AU - Hill, Adrian V S

AU - Teo, Yik Ying

AU - Rockett, Kirk A.

AU - Craddock, Nick

AU - Attwood, Antony P.

AU - Bryan, Claire

AU - Bumpstead, Suzannah J.

AU - Chaney, Amy

AU - Ghori, Jilur

AU - William, Rhian G.

AU - Hunt, Sarah E.

AU - Inouye, Michael

AU - Keniry, Emma

AU - King, Emma

AU - McGinnis, Ralph

AU - Potter, Simon

AU - Ravindrarajan, Rathi

AU - Whittaker, Pamela

AU - Withers, David

AU - Bentley, David

AU - Groves, Christopher J.

AU - Duncanson, Audrey

AU - Ouwehand, Willem H.

AU - Boorman, James P.

AU - Cant, Barbera

AU - Jolley, Jennifer D.

AU - Knight, Alexandra S.

AU - Koch, Kerstin

AU - Taylor, Niall C.

AU - Watkins, Nicholas A.

AU - Winzer, Thilo

AU - Braund, Peter S.

AU - Dixon, Richard J.

AU - Mangino, Massimo

AU - Stevens, Suzanne

AU - Donnely, Peter

AU - Davidson, Dan

AU - Marchini, Jonathan L.

AU - Spencer, I. C A

AU - Cardin, Niall J.

AU - Ferreira, Teresa

AU - Pereira-Gale, Joanne

AU - Hallgrimsdottir, Ingeleif B.

AU - Howie, Bryan N.

AU - Su, Zhan

AU - Vukcevic, Damjan

AU - Easton, Doug

AU - Everson, Ursula

AU - Hussey, Judith M.

AU - Meech, Elizabeth

AU - Prowse, Christopher V.

AU - Walters, Graham R.

AU - Jones, Richard W.

AU - Ring, Susan M.

AU - Prembey, Marcus

AU - Breen, Gerome

AU - St. Clair, David

AU - Ceasar, Sian

AU - Gordon-Smith, Katherine

AU - Jones, Lisa

AU - Green, Elaine K.

AU - Grozeva, Detelinea

AU - Hamshere, Marian L.

AU - Holmans, Peter A.

AU - Jones, Ian R.

AU - Kirov, George

AU - Moskovina, Valentina

AU - Nikolov, Ivan

AU - O'Donovan, Michael C.

AU - Owen, Michael J.

AU - Craddock, Nick

AU - Collier, David A.

AU - Elkin, Amanda

AU - Farmer, Anne

AU - Williamson, Richard

AU - McGruffin, Peter

AU - Young, Allan H.

AU - Ferrier, I. Nicol

AU - Ball, Stephen G.

AU - Balmforth, Anthony J.

AU - Barrett, Jennifer H.

AU - Bishop, D. Timothy

AU - Iles, Mark M.

AU - Maqbool, Azhar

AU - Yuldasheva, Nadira

AU - Hall, Alistair S.

AU - Bredin, Francesca

AU - Tremelling, Mark

AU - Parkes, Miles

AU - Drummond, Hazel

AU - Lees, Charles W.

AU - Nimmo, Elaine R.

AU - Satsangi, Jack

AU - Fisher, Sheila A.

AU - Lewis, Cathryn M.

AU - Onnie, Clive M.

AU - Prescott, Nathalie J.

AU - Mathew, Christopher G.

AU - Forbes, Alastair

AU - Sanderson, Jeremy

AU - Mathew, Christopher

AU - Barbour, Jamie

AU - Mohiuddin, M. Khalid

AU - Todhunter, Catherine E.

AU - Mansfield, John C.

AU - Ahmad, Tariq

AU - Cummings, Fraser R.

AU - Jewell, Derek P.

AU - Barton, Anne

AU - Bruce, Ian N.

AU - Donovan, Hannah

AU - Eyre, Steve

AU - Gilbert, Paul D.

AU - Hider, Samantha L.

AU - Hinks, Anne M.

AU - John, Sally L.

AU - Potter, Catherine

AU - Silman, Alan J.

AU - Symmons, Deborah P M

AU - Thomson, Wendy

AU - Worthington, Jane

AU - Frayling, Timothy M.

AU - Freathy, Rachel M.

AU - Lango, Hana

AU - Perry, John R B

AU - Weedon, Michael N.

AU - Hattersley, Andrew T.

AU - Shields, Beverley M.

AU - Hitman, Graham A.

AU - Walker, Mark

AU - Newport, Melanie

AU - Sirugo, Giorgio

AU - Conway, David

AU - Jallow, Muminatou

AU - Bradbury, Linda A.

AU - Pointon, Jennifer L.

AU - Brown, Matthew A.

AU - Farrar, Claire

AU - Wordsworth, Paul

AU - Franklyn, Jayne A.

AU - Heward, Joanne M.

AU - Simmonds, Matthew J.

AU - Cough, Stephen C L

AU - Seal, Sheila

AU - Stratton, Michael R.

AU - Rahman, Nazneen

AU - Goris, An

AU - Sawcer, Stephen J.

AU - Compston, Alastair

PY - 2009/6

Y1 - 2009/6

N2 - Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N 71,225 European ancestry, N 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10 24), CYP1A2 (P = 1 × 10 23), FGF5 (P = 1 × 10 21), SH2B3 (P = 3 × 10 18), MTHFR (P = 2 × 10 13), c10orf107 (P = 1 × 10 9), ZNF652 (P = 5 × 10 9) and PLCD3 (P = 1 × 10 8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

AB - Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N 71,225 European ancestry, N 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10 24), CYP1A2 (P = 1 × 10 23), FGF5 (P = 1 × 10 21), SH2B3 (P = 3 × 10 18), MTHFR (P = 2 × 10 13), c10orf107 (P = 1 × 10 9), ZNF652 (P = 5 × 10 9) and PLCD3 (P = 1 × 10 8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

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U2 - 10.1038/ng.361

DO - 10.1038/ng.361

M3 - Article

C2 - 19430483

AN - SCOPUS:67349085063

VL - 41

SP - 666

EP - 676

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 6

ER -