TY - JOUR
T1 - Genome-wide association study identifies common variants associated with circulating vitamin E levels
AU - Major, Jacqueline M.
AU - Yu, Kai
AU - Wheeler, William
AU - Zhang, Hong
AU - Cornelis, Marilyn C.
AU - Wright, Margaret E.
AU - Yeager, Meredith
AU - Snyder, Kirk
AU - Weinstein, Stephanie J.
AU - Mondul, Alison
AU - Eliassen, Heather
AU - Purdue, Mark
AU - Hazra, Aditi
AU - McCarty, Catherine A.
AU - Hendrickson, Sara
AU - Virtamo, Jarmo
AU - Hunter, David
AU - Chanock, Stephen
AU - Kraft, Peter
AU - Albanes, Demetrius
N1 - Funding Information:
This work was supported in part by the Intramural Research Program of the National Institutes of Health and the National Cancer Institute. Additionally, the research was supported by Public Health Service contracts (N01-CN-45165, N01-RC-45035, N01-RC-37004 and HHSN261201000006C) from the National Cancer Institute, Department of Health and Human Services. S.H. is supported in part by training grant NIH 5 T32 CA09001-35. H.E. is supported in part by grant NIH R01 CA131218.
PY - 2011/10
Y1 - 2011/10
N2 - In genome-wide association studies (GWAS) of common genetic variants associated with circulating alphaand gamma-tocopherol concentrations in two adult cohorts comprising 5006 men of European descent, we observed three loci associated with alpha-tocopherol levels, two novel single-nucleotide polymorphisms (SNPs), rs2108622 on 19pter-p13.11 (P = 1.7 × 10 -8) and rs11057830 on 12q24.31 (P = 2.0 × 10 -8) and confirmed a previously reported locus marked by rs964184 on 11q23.3 (P = 2.7 × 10 -10). The three SNPs have been reported to be associated with lipid metabolism and/or regulation. We replicated these findings in a combined meta-analysis with two independent samples, P = 7.8 × 10 -12 (rs964184 on 11q23.3 near BUD13, ZNF259 and APOA1/C3/A4/A5), P = 1.4 × 10 -10 (rs2108622 on 19pter-p13.11 near CYP4F2) and P = 8.2 × 10 -9 (rs11057830 on 12q24.31 near SCARB1). Combined, these SNPs explain 1.7% of the residual variance in log alpha-tocopherol levels. In one of the two male GWAS cohorts (n = 992), no SNPs were significantly associated with gamma-tocopherol concentrations after including data from the replication sample for 71 independent SNPs with P < 1 × 10 -4 identified. Published by Oxford University Press 2011.
AB - In genome-wide association studies (GWAS) of common genetic variants associated with circulating alphaand gamma-tocopherol concentrations in two adult cohorts comprising 5006 men of European descent, we observed three loci associated with alpha-tocopherol levels, two novel single-nucleotide polymorphisms (SNPs), rs2108622 on 19pter-p13.11 (P = 1.7 × 10 -8) and rs11057830 on 12q24.31 (P = 2.0 × 10 -8) and confirmed a previously reported locus marked by rs964184 on 11q23.3 (P = 2.7 × 10 -10). The three SNPs have been reported to be associated with lipid metabolism and/or regulation. We replicated these findings in a combined meta-analysis with two independent samples, P = 7.8 × 10 -12 (rs964184 on 11q23.3 near BUD13, ZNF259 and APOA1/C3/A4/A5), P = 1.4 × 10 -10 (rs2108622 on 19pter-p13.11 near CYP4F2) and P = 8.2 × 10 -9 (rs11057830 on 12q24.31 near SCARB1). Combined, these SNPs explain 1.7% of the residual variance in log alpha-tocopherol levels. In one of the two male GWAS cohorts (n = 992), no SNPs were significantly associated with gamma-tocopherol concentrations after including data from the replication sample for 71 independent SNPs with P < 1 × 10 -4 identified. Published by Oxford University Press 2011.
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U2 - 10.1093/hmg/ddr296
DO - 10.1093/hmg/ddr296
M3 - Article
C2 - 21729881
AN - SCOPUS:80052708806
VL - 20
SP - 3876
EP - 3883
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 19
M1 - ddr296
ER -