@article{c17c49b6f0784b47bf21ab6eeecadf14,
title = "Genome wide association study (GWAS) between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD)",
abstract = "Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.",
keywords = "ADHD, EQTL, GWAS, Meta-analysis, OCD, Polygenic score, Protein-protein link analysis",
author = "Ritter, {McKenzie L.} and Wei Guo and Samuel, {Jack F.} and Ying Wang and Nestadt, {Paul S.} and Janice Krasnow and Greenberg, {Benjamin D.} and Fyer, {Abby J.} and McCracken, {James T.} and Geller, {Daniel A.} and Murphy, {Dennis L.} and Knowles, {James A.} and Grados, {Marco A.} and Riddle, {Mark A.} and Rasmussen, {Steven A.} and McLaughlin, {Nicole C.} and Nurmi, {Erika L.} and Askland, {Kathleen D.} and Bernadette Cullen and John Piacentini and Pauls, {David L.} and Joseph Bienvenu and Evelyn Stewart and Goes, {Fernando S.} and Brion Maher and Pulver, {Ann E.} and Manuel Mattheisen and Ji Qian and Gerald Nestadt and Shugart, {Yin Yao}",
note = "Publisher Copyright: {\textcopyright} 2017 Ritter, Guo, Samuels, Wang, Nestadt, Krasnow, Greenberg, Fyer, McCracken, Geller, Murphy, Knowles, Grados, Riddle, Rasmussen, McLaughlin, Nurmi, Askland, Cullen, Piacentini, Pauls, Bienvenu, Stewart, Goes, Maher, Pulver, Mattheisen, Qian, Nestadt and Shugart.",
year = "2017",
month = mar,
day = "23",
doi = "10.3389/fnmol.2017.00083",
language = "English (US)",
volume = "10",
journal = "Frontiers in Molecular Neuroscience",
issn = "1662-5099",
publisher = "Frontiers Research Foundation",
}