Genome wide association study (GWAS) between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD)

McKenzie L. Ritter, Wei Guo, Jack F. Samuel, Ying Wang, Paul Nestadt, Janice Krasnow, Benjamin D. Greenberg, Abby J. Fyer, James T. McCracken, Daniel A. Geller, Dennis L. Murphy, James A. Knowles, Marco Grados, Mark A Riddle, Steven A. Rasmussen, Nicole C. McLaughlin, Erika L. Nurmi, Kathleen D. Askland, Bernadette Cullen, John PiacentiniDavid L. Pauls, Oscar J Bienvenu, Evelyn Stewart, Fernando S Goes, Brion Maher, Ann E Pulver, Manuel Mattheisen, Ji Qian, Gerald Nestadt, Yin Yao Shugart

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.

Original languageEnglish (US)
Article number83
JournalFrontiers in Molecular Neuroscience
Volume10
DOIs
StatePublished - Mar 23 2017

Keywords

  • ADHD
  • EQTL
  • GWAS
  • Meta-analysis
  • OCD
  • Polygenic score
  • Protein-protein link analysis

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Genome wide association study (GWAS) between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD)'. Together they form a unique fingerprint.

  • Cite this

    Ritter, M. L., Guo, W., Samuel, J. F., Wang, Y., Nestadt, P., Krasnow, J., Greenberg, B. D., Fyer, A. J., McCracken, J. T., Geller, D. A., Murphy, D. L., Knowles, J. A., Grados, M., Riddle, M. A., Rasmussen, S. A., McLaughlin, N. C., Nurmi, E. L., Askland, K. D., Cullen, B., ... Shugart, Y. Y. (2017). Genome wide association study (GWAS) between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). Frontiers in Molecular Neuroscience, 10, [83]. https://doi.org/10.3389/fnmol.2017.00083