Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error

the CREAM consortium

Qing Li, Robert Wojciechowski, Claire L. Simpson, Pirro G. Hysi, Virginie J M Verhoeven, Mohammad Kamran Ikram, René Höhn, Veronique Vitart, Alex W. Hewitt, Konrad Oexle, Kari Matti Mäkelä, Stuart MacGregor, Mario Pirastu, Qiao Fan, Ching Yu Cheng, Beaté St Pourcain, George McMahon, John P. Kemp, Kate Northstone, Jugnoo S. Rahi & 69 others Phillippa M. Cumberland, Nicholas G. Martin, Paul G. Sanfilippo, Yi Lu, Ya Xing Wang, Caroline Hayward, Ozren Polašek, Harry Campbell, Goran Bencic, Alan F. Wright, Juho Wedenoja, Tanja Zeller, Arne Schillert, Alireza Mirshahi, Karl Lackner, Shea Ping Yip, Maurice K H Yap, Janina S. Ried, Christian Gieger, Federico Murgia, James F. Wilson, Brian Fleck, Seyhan Yazar, Johannes R. Vingerling, Albert Hofman, André Uitterlinden, Fernando Rivadeneira, Najaf Amin, Lennart Karssen, Ben A. Oostra, Xin Zhou, Yik Ying Teo, E. Shyong Tai, Eranga Vithana, Veluchamy Barathi, Yingfeng Zheng, Rosalynn Grace Siantar, Kumari Neelam, Youchan Shin, Janice Lam, Ekaterina Yonova-Doing, Cristina Venturini, S. Mohsen Hosseini, Hoi Suen Wong, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, Nicholas J. Timpson, David M. Evans, Chiea Chuen Khor, Tin Aung, Terri L. Young, Paul Mitchell, Barbara Klein, Cornelia M. van Duijn, Thomas Meitinger, Jost B. Jonas, Paul N. Baird, David A. Mackey, Tien Yin Wong, Seang Mei Saw, Olavi Pärssinen, Dwight Stambolian, Christopher J. Hammond, Caroline C W Klaver, Cathy Williams, Andrew D. Paterson, Joan E. Bailey-Wilson, Jeremy A. Guggenheim

Research output: Contribution to journalArticle

Abstract

To identify genetic variants associated with refractive astigmatism in the general population, meta-analyses of genome-wide association studies were performed for: White Europeans aged at least 25 years (20 cohorts, N = 31,968); Asian subjects aged at least 25 years (7 cohorts, N = 9,295); White Europeans aged

Original languageEnglish (US)
Pages (from-to)131-146
Number of pages16
JournalHuman Genetics
Volume134
Issue number2
DOIs
StatePublished - 2015

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Refractive Errors
Astigmatism
Genome-Wide Association Study
Meta-Analysis
Population

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error : the CREAM consortium. / Li, Qing; Wojciechowski, Robert; Simpson, Claire L.; Hysi, Pirro G.; Verhoeven, Virginie J M; Ikram, Mohammad Kamran; Höhn, René; Vitart, Veronique; Hewitt, Alex W.; Oexle, Konrad; Mäkelä, Kari Matti; MacGregor, Stuart; Pirastu, Mario; Fan, Qiao; Cheng, Ching Yu; St Pourcain, Beaté; McMahon, George; Kemp, John P.; Northstone, Kate; Rahi, Jugnoo S.; Cumberland, Phillippa M.; Martin, Nicholas G.; Sanfilippo, Paul G.; Lu, Yi; Wang, Ya Xing; Hayward, Caroline; Polašek, Ozren; Campbell, Harry; Bencic, Goran; Wright, Alan F.; Wedenoja, Juho; Zeller, Tanja; Schillert, Arne; Mirshahi, Alireza; Lackner, Karl; Yip, Shea Ping; Yap, Maurice K H; Ried, Janina S.; Gieger, Christian; Murgia, Federico; Wilson, James F.; Fleck, Brian; Yazar, Seyhan; Vingerling, Johannes R.; Hofman, Albert; Uitterlinden, André; Rivadeneira, Fernando; Amin, Najaf; Karssen, Lennart; Oostra, Ben A.; Zhou, Xin; Teo, Yik Ying; Tai, E. Shyong; Vithana, Eranga; Barathi, Veluchamy; Zheng, Yingfeng; Siantar, Rosalynn Grace; Neelam, Kumari; Shin, Youchan; Lam, Janice; Yonova-Doing, Ekaterina; Venturini, Cristina; Hosseini, S. Mohsen; Wong, Hoi Suen; Lehtimäki, Terho; Kähönen, Mika; Raitakari, Olli; Timpson, Nicholas J.; Evans, David M.; Khor, Chiea Chuen; Aung, Tin; Young, Terri L.; Mitchell, Paul; Klein, Barbara; van Duijn, Cornelia M.; Meitinger, Thomas; Jonas, Jost B.; Baird, Paul N.; Mackey, David A.; Wong, Tien Yin; Saw, Seang Mei; Pärssinen, Olavi; Stambolian, Dwight; Hammond, Christopher J.; Klaver, Caroline C W; Williams, Cathy; Paterson, Andrew D.; Bailey-Wilson, Joan E.; Guggenheim, Jeremy A.

In: Human Genetics, Vol. 134, No. 2, 2015, p. 131-146.

Research output: Contribution to journalArticle

Li, Q, Wojciechowski, R, Simpson, CL, Hysi, PG, Verhoeven, VJM, Ikram, MK, Höhn, R, Vitart, V, Hewitt, AW, Oexle, K, Mäkelä, KM, MacGregor, S, Pirastu, M, Fan, Q, Cheng, CY, St Pourcain, B, McMahon, G, Kemp, JP, Northstone, K, Rahi, JS, Cumberland, PM, Martin, NG, Sanfilippo, PG, Lu, Y, Wang, YX, Hayward, C, Polašek, O, Campbell, H, Bencic, G, Wright, AF, Wedenoja, J, Zeller, T, Schillert, A, Mirshahi, A, Lackner, K, Yip, SP, Yap, MKH, Ried, JS, Gieger, C, Murgia, F, Wilson, JF, Fleck, B, Yazar, S, Vingerling, JR, Hofman, A, Uitterlinden, A, Rivadeneira, F, Amin, N, Karssen, L, Oostra, BA, Zhou, X, Teo, YY, Tai, ES, Vithana, E, Barathi, V, Zheng, Y, Siantar, RG, Neelam, K, Shin, Y, Lam, J, Yonova-Doing, E, Venturini, C, Hosseini, SM, Wong, HS, Lehtimäki, T, Kähönen, M, Raitakari, O, Timpson, NJ, Evans, DM, Khor, CC, Aung, T, Young, TL, Mitchell, P, Klein, B, van Duijn, CM, Meitinger, T, Jonas, JB, Baird, PN, Mackey, DA, Wong, TY, Saw, SM, Pärssinen, O, Stambolian, D, Hammond, CJ, Klaver, CCW, Williams, C, Paterson, AD, Bailey-Wilson, JE & Guggenheim, JA 2015, 'Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium', Human Genetics, vol. 134, no. 2, pp. 131-146. https://doi.org/10.1007/s00439-014-1500-y
Li, Qing ; Wojciechowski, Robert ; Simpson, Claire L. ; Hysi, Pirro G. ; Verhoeven, Virginie J M ; Ikram, Mohammad Kamran ; Höhn, René ; Vitart, Veronique ; Hewitt, Alex W. ; Oexle, Konrad ; Mäkelä, Kari Matti ; MacGregor, Stuart ; Pirastu, Mario ; Fan, Qiao ; Cheng, Ching Yu ; St Pourcain, Beaté ; McMahon, George ; Kemp, John P. ; Northstone, Kate ; Rahi, Jugnoo S. ; Cumberland, Phillippa M. ; Martin, Nicholas G. ; Sanfilippo, Paul G. ; Lu, Yi ; Wang, Ya Xing ; Hayward, Caroline ; Polašek, Ozren ; Campbell, Harry ; Bencic, Goran ; Wright, Alan F. ; Wedenoja, Juho ; Zeller, Tanja ; Schillert, Arne ; Mirshahi, Alireza ; Lackner, Karl ; Yip, Shea Ping ; Yap, Maurice K H ; Ried, Janina S. ; Gieger, Christian ; Murgia, Federico ; Wilson, James F. ; Fleck, Brian ; Yazar, Seyhan ; Vingerling, Johannes R. ; Hofman, Albert ; Uitterlinden, André ; Rivadeneira, Fernando ; Amin, Najaf ; Karssen, Lennart ; Oostra, Ben A. ; Zhou, Xin ; Teo, Yik Ying ; Tai, E. Shyong ; Vithana, Eranga ; Barathi, Veluchamy ; Zheng, Yingfeng ; Siantar, Rosalynn Grace ; Neelam, Kumari ; Shin, Youchan ; Lam, Janice ; Yonova-Doing, Ekaterina ; Venturini, Cristina ; Hosseini, S. Mohsen ; Wong, Hoi Suen ; Lehtimäki, Terho ; Kähönen, Mika ; Raitakari, Olli ; Timpson, Nicholas J. ; Evans, David M. ; Khor, Chiea Chuen ; Aung, Tin ; Young, Terri L. ; Mitchell, Paul ; Klein, Barbara ; van Duijn, Cornelia M. ; Meitinger, Thomas ; Jonas, Jost B. ; Baird, Paul N. ; Mackey, David A. ; Wong, Tien Yin ; Saw, Seang Mei ; Pärssinen, Olavi ; Stambolian, Dwight ; Hammond, Christopher J. ; Klaver, Caroline C W ; Williams, Cathy ; Paterson, Andrew D. ; Bailey-Wilson, Joan E. ; Guggenheim, Jeremy A. / Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error : the CREAM consortium. In: Human Genetics. 2015 ; Vol. 134, No. 2. pp. 131-146.
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AU - Li, Qing

AU - Wojciechowski, Robert

AU - Simpson, Claire L.

AU - Hysi, Pirro G.

AU - Verhoeven, Virginie J M

AU - Ikram, Mohammad Kamran

AU - Höhn, René

AU - Vitart, Veronique

AU - Hewitt, Alex W.

AU - Oexle, Konrad

AU - Mäkelä, Kari Matti

AU - MacGregor, Stuart

AU - Pirastu, Mario

AU - Fan, Qiao

AU - Cheng, Ching Yu

AU - St Pourcain, Beaté

AU - McMahon, George

AU - Kemp, John P.

AU - Northstone, Kate

AU - Rahi, Jugnoo S.

AU - Cumberland, Phillippa M.

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AU - Sanfilippo, Paul G.

AU - Lu, Yi

AU - Wang, Ya Xing

AU - Hayward, Caroline

AU - Polašek, Ozren

AU - Campbell, Harry

AU - Bencic, Goran

AU - Wright, Alan F.

AU - Wedenoja, Juho

AU - Zeller, Tanja

AU - Schillert, Arne

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AU - Lackner, Karl

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AU - Yap, Maurice K H

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AU - Wilson, James F.

AU - Fleck, Brian

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AU - Hofman, Albert

AU - Uitterlinden, André

AU - Rivadeneira, Fernando

AU - Amin, Najaf

AU - Karssen, Lennart

AU - Oostra, Ben A.

AU - Zhou, Xin

AU - Teo, Yik Ying

AU - Tai, E. Shyong

AU - Vithana, Eranga

AU - Barathi, Veluchamy

AU - Zheng, Yingfeng

AU - Siantar, Rosalynn Grace

AU - Neelam, Kumari

AU - Shin, Youchan

AU - Lam, Janice

AU - Yonova-Doing, Ekaterina

AU - Venturini, Cristina

AU - Hosseini, S. Mohsen

AU - Wong, Hoi Suen

AU - Lehtimäki, Terho

AU - Kähönen, Mika

AU - Raitakari, Olli

AU - Timpson, Nicholas J.

AU - Evans, David M.

AU - Khor, Chiea Chuen

AU - Aung, Tin

AU - Young, Terri L.

AU - Mitchell, Paul

AU - Klein, Barbara

AU - van Duijn, Cornelia M.

AU - Meitinger, Thomas

AU - Jonas, Jost B.

AU - Baird, Paul N.

AU - Mackey, David A.

AU - Wong, Tien Yin

AU - Saw, Seang Mei

AU - Pärssinen, Olavi

AU - Stambolian, Dwight

AU - Hammond, Christopher J.

AU - Klaver, Caroline C W

AU - Williams, Cathy

AU - Paterson, Andrew D.

AU - Bailey-Wilson, Joan E.

AU - Guggenheim, Jeremy A.

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