Genome-wide association studies of refractive error and myopia, lessons learned, and implications for the future

Pirro G. Hysi, Robert Wojciechowski, Jugnoo S. Rahi, Chris J. Hammond

Research output: Contribution to journalReview articlepeer-review

Abstract

The investigation of the genetic basis of refractive error and myopia entered a new stage with the introduction of genome-wide association studies (GWAS). Multiple GWAS on many ethnic groups have been published over the years, providing new insight into the genetic architecture and pathophysiology of refractive error. This is a review of the GWAS published to date, the main lessons learned, and future possible directions of genetic studies of myopia and refractive error.

Original languageEnglish (US)
Pages (from-to)3344-3351
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume55
Issue number5
DOIs
StatePublished - May 29 2014

Keywords

  • GWAS
  • Genetic architecture
  • Refractive error

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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