Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma

Jason D. Christie; Mark M. Wurfel; Rui Feng; Grant E. O'Keefe; Jonathan Bradfield; Lorraine B. Ware; David C. Christiani; Carolyn S. Calfee; Mitchell J. Cohen; Michael Matthay; Nuala J. Meyer; Cecilia Kim; Mingyao Li; Joshua Akey; Kathleen C. Barnes; Jonathan Sevransky; Paul N. Lanken; Addison K. May; Richard Aplenc; James P. Maloney; Hakon Hakonarson

doi:10.1371/journal.pone.0028268

Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma

Jason D. Christie, Mark M. Wurfel, Rui Feng, Grant E. O'Keefe, Jonathan Bradfield, Lorraine B. Ware, David C. Christiani, Carolyn S. Calfee, Mitchell J. Cohen, Michael Matthay, Nuala J. Meyer, Cecilia Kim, Mingyao Li, Joshua Akey, Kathleen C. Barnes, Jonathan Sevransky, Paul N. Lanken, Addison K. May, Richard Aplenc, James P. MaloneyHakon Hakonarson

School of Medicine

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA) approach to identify putative risk variants for ALI. Genome wide genotyping was performed using the Illumina Human Quad 610 BeadChip. We performed a two-stage GWA study followed by a third stage of functional characterization. In the discovery phase (Phase 1), we compared 600 European American trauma-associated ALI cases with 2266 European American population-based controls. We carried forward the top 1% of single nucleotide polymorphisms (SNPs) at p

Original language	English (US)
Article number	e28268
Journal	PLoS One
Volume	7
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0028268
State	Published - Jan 25 2012

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology
General Medicine

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Christie, J. D., Wurfel, M. M., Feng, R., O'Keefe, G. E., Bradfield, J., Ware, L. B., Christiani, D. C., Calfee, C. S., Cohen, M. J., Matthay, M., Meyer, N. J., Kim, C., Li, M., Akey, J., Barnes, K. C., Sevransky, J., Lanken, P. N., May, A. K., Aplenc, R., ... Hakonarson, H. (2012). Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One, 7(1), Article e28268. https://doi.org/10.1371/journal.pone.0028268

Christie, JD, Wurfel, MM, Feng, R, O'Keefe, GE, Bradfield, J, Ware, LB, Christiani, DC, Calfee, CS, Cohen, MJ, Matthay, M, Meyer, NJ, Kim, C, Li, M, Akey, J, Barnes, KC, Sevransky, J, Lanken, PN, May, AK, Aplenc, R, Maloney, JP & Hakonarson, H 2012, 'Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma', PLoS One, vol. 7, no. 1, e28268. https://doi.org/10.1371/journal.pone.0028268

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abstract = "Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA) approach to identify putative risk variants for ALI. Genome wide genotyping was performed using the Illumina Human Quad 610 BeadChip. We performed a two-stage GWA study followed by a third stage of functional characterization. In the discovery phase (Phase 1), we compared 600 European American trauma-associated ALI cases with 2266 European American population-based controls. We carried forward the top 1% of single nucleotide polymorphisms (SNPs) at p",

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Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma

Abstract

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