Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Jennifer L. Bolton, Caroline Hayward, Nese Direk, John G. Lewis, Geoffrey L. Hammond, Lesley A. Hill, Anna Anderson, Jennifer Huffman, James F. Wilson, Harry Campbell, Igor Rudan, Alan Wright, Nicholas Hastie, Sarah H. Wild, Fleur P. Velders, Albert Hofman, Andre G. Uitterlinden, Jari Lahti, Katri Räikkönen, Eero KajantieElisabeth Widen, Aarno Palotie, Johan G. Eriksson, Marika Kaakinen, Marjo Riitta Järvelin, Nicholas J. Timpson, George Davey Smith, Susan M. Ring, David M. Evans, Beate St Pourcain, Toshiko Tanaka, Yuri Milaneschi, Stefania Bandinelli, Luigi Ferrucci, Pim van der Harst, Judith G M Rosmalen, Stephen J L Bakker, Niek Verweij, Robin P F Dullaart, Anubha Mahajan, Cecilia M. Lindgren, Andrew Morris, Lars Lind, Erik Ingelsson, Laura N. Anderson, Craig E. Pennell, Stephen J. Lye, Stephen G. Matthews, Joel Eriksson, Dan Mellstrom, Claes Ohlsson, Jackie F. Price, Mark W J Strachan, Rebecca M. Reynolds, Henning Tiemeier, Brian R. Walker

Research output: Contribution to journalArticle

Abstract

Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that

Original languageEnglish (US)
Article numbere1004474
JournalPLoS Genetics
Volume10
Issue number7
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Transcortin
adrenal cortex hormones
globulins
cortisol
Hydrocortisone
genome
Genome
plasma
loci
meta-analysis
heritability
hormone
Genome-Wide Association Study
Meta-Analysis
stress response
hormones
Hormones
cortisol binding globulin
Population

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)
  • Medicine(all)

Cite this

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin. / Bolton, Jennifer L.; Hayward, Caroline; Direk, Nese; Lewis, John G.; Hammond, Geoffrey L.; Hill, Lesley A.; Anderson, Anna; Huffman, Jennifer; Wilson, James F.; Campbell, Harry; Rudan, Igor; Wright, Alan; Hastie, Nicholas; Wild, Sarah H.; Velders, Fleur P.; Hofman, Albert; Uitterlinden, Andre G.; Lahti, Jari; Räikkönen, Katri; Kajantie, Eero; Widen, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Kaakinen, Marika; Järvelin, Marjo Riitta; Timpson, Nicholas J.; Davey Smith, George; Ring, Susan M.; Evans, David M.; St Pourcain, Beate; Tanaka, Toshiko; Milaneschi, Yuri; Bandinelli, Stefania; Ferrucci, Luigi; van der Harst, Pim; Rosmalen, Judith G M; Bakker, Stephen J L; Verweij, Niek; Dullaart, Robin P F; Mahajan, Anubha; Lindgren, Cecilia M.; Morris, Andrew; Lind, Lars; Ingelsson, Erik; Anderson, Laura N.; Pennell, Craig E.; Lye, Stephen J.; Matthews, Stephen G.; Eriksson, Joel; Mellstrom, Dan; Ohlsson, Claes; Price, Jackie F.; Strachan, Mark W J; Reynolds, Rebecca M.; Tiemeier, Henning; Walker, Brian R.

In: PLoS Genetics, Vol. 10, No. 7, e1004474, 2014.

Research output: Contribution to journalArticle

Bolton, JL, Hayward, C, Direk, N, Lewis, JG, Hammond, GL, Hill, LA, Anderson, A, Huffman, J, Wilson, JF, Campbell, H, Rudan, I, Wright, A, Hastie, N, Wild, SH, Velders, FP, Hofman, A, Uitterlinden, AG, Lahti, J, Räikkönen, K, Kajantie, E, Widen, E, Palotie, A, Eriksson, JG, Kaakinen, M, Järvelin, MR, Timpson, NJ, Davey Smith, G, Ring, SM, Evans, DM, St Pourcain, B, Tanaka, T, Milaneschi, Y, Bandinelli, S, Ferrucci, L, van der Harst, P, Rosmalen, JGM, Bakker, SJL, Verweij, N, Dullaart, RPF, Mahajan, A, Lindgren, CM, Morris, A, Lind, L, Ingelsson, E, Anderson, LN, Pennell, CE, Lye, SJ, Matthews, SG, Eriksson, J, Mellstrom, D, Ohlsson, C, Price, JF, Strachan, MWJ, Reynolds, RM, Tiemeier, H & Walker, BR 2014, 'Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin', PLoS Genetics, vol. 10, no. 7, e1004474. https://doi.org/10.1371/journal.pgen.1004474
Bolton, Jennifer L. ; Hayward, Caroline ; Direk, Nese ; Lewis, John G. ; Hammond, Geoffrey L. ; Hill, Lesley A. ; Anderson, Anna ; Huffman, Jennifer ; Wilson, James F. ; Campbell, Harry ; Rudan, Igor ; Wright, Alan ; Hastie, Nicholas ; Wild, Sarah H. ; Velders, Fleur P. ; Hofman, Albert ; Uitterlinden, Andre G. ; Lahti, Jari ; Räikkönen, Katri ; Kajantie, Eero ; Widen, Elisabeth ; Palotie, Aarno ; Eriksson, Johan G. ; Kaakinen, Marika ; Järvelin, Marjo Riitta ; Timpson, Nicholas J. ; Davey Smith, George ; Ring, Susan M. ; Evans, David M. ; St Pourcain, Beate ; Tanaka, Toshiko ; Milaneschi, Yuri ; Bandinelli, Stefania ; Ferrucci, Luigi ; van der Harst, Pim ; Rosmalen, Judith G M ; Bakker, Stephen J L ; Verweij, Niek ; Dullaart, Robin P F ; Mahajan, Anubha ; Lindgren, Cecilia M. ; Morris, Andrew ; Lind, Lars ; Ingelsson, Erik ; Anderson, Laura N. ; Pennell, Craig E. ; Lye, Stephen J. ; Matthews, Stephen G. ; Eriksson, Joel ; Mellstrom, Dan ; Ohlsson, Claes ; Price, Jackie F. ; Strachan, Mark W J ; Reynolds, Rebecca M. ; Tiemeier, Henning ; Walker, Brian R. / Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin. In: PLoS Genetics. 2014 ; Vol. 10, No. 7.
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abstract = "Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60{\%} but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that",
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AU - Lewis, John G.

AU - Hammond, Geoffrey L.

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AU - Timpson, Nicholas J.

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AU - Ring, Susan M.

AU - Evans, David M.

AU - St Pourcain, Beate

AU - Tanaka, Toshiko

AU - Milaneschi, Yuri

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