Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Jennifer L. Bolton, Caroline Hayward, Nese Direk, John G. Lewis, Geoffrey L. Hammond, Lesley A. Hill, Anna Anderson, Jennifer Huffman, James F. Wilson, Harry Campbell, Igor Rudan, Alan Wright, Nicholas Hastie, Sarah H. Wild, Fleur P. Velders, Albert Hofman, Andre G. Uitterlinden, Jari Lahti, Katri Räikkönen, Eero KajantieElisabeth Widen, Aarno Palotie, Johan G. Eriksson, Marika Kaakinen, Marjo Riitta Järvelin, Nicholas J. Timpson, George Davey Smith, Susan M. Ring, David M. Evans, Beate St Pourcain, Toshiko Tanaka, Yuri Milaneschi, Stefania Bandinelli, Luigi Ferrucci, Pim van der Harst, Judith G M Rosmalen, Stephen J L Bakker, Niek Verweij, Robin P F Dullaart, Anubha Mahajan, Cecilia M. Lindgren, Andrew Morris, Lars Lind, Erik Ingelsson, Laura N. Anderson, Craig E. Pennell, Stephen J. Lye, Stephen G. Matthews, Joel Eriksson, Dan Mellstrom, Claes Ohlsson, Jackie F. Price, Mark W J Strachan, Rebecca M. Reynolds, Henning Tiemeier, Brian R. Walker

Research output: Contribution to journalArticle

Abstract

Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that

Original languageEnglish (US)
Article numbere1004474
JournalPLoS Genetics
Volume10
Issue number7
DOIs
Publication statusPublished - 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)
  • Medicine(all)

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