Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Jennifer L. Bolton; Caroline Hayward; Nese Direk; John G. Lewis; Geoffrey L. Hammond; Lesley A. Hill; Anna Anderson; Jennifer Huffman; James F. Wilson; Harry Campbell; Igor Rudan; Alan Wright; Nicholas Hastie; Sarah H. Wild; Fleur P. Velders; Albert Hofman; Andre G. Uitterlinden; Jari Lahti; Katri Räikkönen; Eero Kajantie; Elisabeth Widen; Aarno Palotie; Johan G. Eriksson; Marika Kaakinen; Marjo Riitta Järvelin; Nicholas J. Timpson; George Davey Smith; Susan M. Ring; David M. Evans; Beate St Pourcain; Toshiko Tanaka; Yuri Milaneschi; Stefania Bandinelli; Luigi Ferrucci; Pim van der Harst; Judith G M Rosmalen; Stephen J L Bakker; Niek Verweij; Robin P F Dullaart; Anubha Mahajan; Cecilia M. Lindgren; Andrew Morris; Lars Lind; Erik Ingelsson; Laura N. Anderson; Craig E. Pennell; Stephen J. Lye; Stephen G. Matthews; Joel Eriksson; Dan Mellstrom; Claes Ohlsson; Jackie F. Price; Mark W J Strachan; Rebecca M. Reynolds; Henning Tiemeier; Brian R. Walker

doi:10.1371/journal.pgen.1004474

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Jennifer L. Bolton, Caroline Hayward, Nese Direk, John G. Lewis, Geoffrey L. Hammond, Lesley A. Hill, Anna Anderson, Jennifer Huffman, James F. Wilson, Harry Campbell, Igor Rudan, Alan Wright, Nicholas Hastie, Sarah H. Wild, Fleur P. Velders, Albert Hofman, Andre G. Uitterlinden, Jari Lahti, Katri Räikkönen, Eero KajantieElisabeth Widen, Aarno Palotie, Johan G. Eriksson, Marika Kaakinen, Marjo Riitta Järvelin, Nicholas J. Timpson, George Davey Smith, Susan M. Ring, David M. Evans, Beate St Pourcain, Toshiko Tanaka, Yuri Milaneschi, Stefania Bandinelli, Luigi Ferrucci, Pim van der Harst, Judith G M Rosmalen, Stephen J L Bakker, Niek Verweij, Robin P F Dullaart, Anubha Mahajan, Cecilia M. Lindgren, Andrew Morris, Lars Lind, Erik Ingelsson, Laura N. Anderson, Craig E. Pennell, Stephen J. Lye, Stephen G. Matthews, Joel Eriksson, Dan Mellstrom, Claes Ohlsson, Jackie F. Price, Mark W J Strachan, Rebecca M. Reynolds, Henning Tiemeier, Brian R. Walker

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that

Original language	English (US)
Article number	e1004474
Journal	PLoS Genetics
Volume	10
Issue number	7
DOIs	https://doi.org/10.1371/journal.pgen.1004474
State	Published - 2014
Externally published	Yes

ASJC Scopus subject areas

Genetics
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Cancer Research
Genetics(clinical)
General Medicine

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10.1371/journal.pgen.1004474

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Bolton, J. L., Hayward, C., Direk, N., Lewis, J. G., Hammond, G. L., Hill, L. A., Anderson, A., Huffman, J., Wilson, J. F., Campbell, H., Rudan, I., Wright, A., Hastie, N., Wild, S. H., Velders, F. P., Hofman, A., Uitterlinden, A. G., Lahti, J., Räikkönen, K., ... Walker, B. R. (2014). Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin. PLoS Genetics, 10(7), Article e1004474. https://doi.org/10.1371/journal.pgen.1004474

Bolton, JL, Hayward, C, Direk, N, Lewis, JG, Hammond, GL, Hill, LA, Anderson, A, Huffman, J, Wilson, JF, Campbell, H, Rudan, I, Wright, A, Hastie, N, Wild, SH, Velders, FP, Hofman, A, Uitterlinden, AG, Lahti, J, Räikkönen, K, Kajantie, E, Widen, E, Palotie, A, Eriksson, JG, Kaakinen, M, Järvelin, MR, Timpson, NJ, Davey Smith, G, Ring, SM, Evans, DM, St Pourcain, B, Tanaka, T, Milaneschi, Y, Bandinelli, S, Ferrucci, L, van der Harst, P, Rosmalen, JGM, Bakker, SJL, Verweij, N, Dullaart, RPF, Mahajan, A, Lindgren, CM, Morris, A, Lind, L, Ingelsson, E, Anderson, LN, Pennell, CE, Lye, SJ, Matthews, SG, Eriksson, J, Mellstrom, D, Ohlsson, C, Price, JF, Strachan, MWJ, Reynolds, RM, Tiemeier, H & Walker, BR 2014, 'Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin', PLoS Genetics, vol. 10, no. 7, e1004474. https://doi.org/10.1371/journal.pgen.1004474

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title = "Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin",

abstract = "Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that ",

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AU - Bolton, Jennifer L.

AU - Hayward, Caroline

AU - Direk, Nese

AU - Lewis, John G.

AU - Hammond, Geoffrey L.

AU - Hill, Lesley A.

AU - Anderson, Anna

AU - Huffman, Jennifer

AU - Wilson, James F.

AU - Campbell, Harry

AU - Rudan, Igor

AU - Wright, Alan

AU - Hastie, Nicholas

AU - Wild, Sarah H.

AU - Velders, Fleur P.

AU - Hofman, Albert

AU - Uitterlinden, Andre G.

AU - Lahti, Jari

AU - Räikkönen, Katri

AU - Kajantie, Eero

AU - Widen, Elisabeth

AU - Palotie, Aarno

AU - Eriksson, Johan G.

AU - Kaakinen, Marika

AU - Järvelin, Marjo Riitta

AU - Timpson, Nicholas J.

AU - Davey Smith, George

AU - Ring, Susan M.

AU - Evans, David M.

AU - St Pourcain, Beate

AU - Tanaka, Toshiko

AU - Milaneschi, Yuri

AU - Bandinelli, Stefania

AU - Ferrucci, Luigi

AU - van der Harst, Pim

AU - Rosmalen, Judith G M

AU - Bakker, Stephen J L

AU - Verweij, Niek

AU - Dullaart, Robin P F

AU - Mahajan, Anubha

AU - Lindgren, Cecilia M.

AU - Morris, Andrew

AU - Lind, Lars

AU - Ingelsson, Erik

AU - Anderson, Laura N.

AU - Pennell, Craig E.

AU - Lye, Stephen J.

AU - Matthews, Stephen G.

AU - Eriksson, Joel

AU - Mellstrom, Dan

AU - Ohlsson, Claes

AU - Price, Jackie F.

AU - Strachan, Mark W J

AU - Reynolds, Rebecca M.

AU - Tiemeier, Henning

AU - Walker, Brian R.

PY - 2014

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Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Abstract

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