Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers

Tomas Drgon, Ivan Montoya, Catherine Johnson, Qing Rong Liu, Donna Walther, Dean Hamer, George R. Uhl

Research output: Contribution to journalArticle

Abstract

Phenotypes related to both nicotine dependence and ability to successfully quit smoking display substantial heritabilities in classical and molecular genetic studies. Twin studies suggest that some genetic components for dependence overlap with genetic components of ability to quit, but that many components do not overlap. Initial genome-wide association (GWA) studies have demonstrated haplotypes that distinguish nicotine-dependent from nondependent smokers. These haplotypes overlap partially with those that distinguish individuals who successfully quit smoking from those who were not able to quit smoking in clinical trials for smoking cessation. We now report novel genome-wide association results from National Institutes of Health research volunteers who reported smoking histories, symptoms of nicotine dependence, and ability to successfully quit smoking outside the context of a clinical trial. These results buttress data from several prior GWA studies. The data from these volunteers support the idea that previously reported studies of genes associated with smoking cessation success in clinical trial participants may also apply to smokers who are more or less able to initiate and sustain abstinence outside of clinical trial settings.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalMolecular Medicine
Volume15
Issue number1-2
DOIs
StatePublished - Jan 2009

Fingerprint

Tobacco Use Disorder
Smoking Cessation
Volunteers
Smoking
Aptitude
Genome
Clinical Trials
Research
Genome-Wide Association Study
Haplotypes
Twin Studies
National Institutes of Health (U.S.)
Nicotine
Molecular Biology
Phenotype
Genes

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)
  • Medicine(all)

Cite this

Drgon, T., Montoya, I., Johnson, C., Liu, Q. R., Walther, D., Hamer, D., & Uhl, G. R. (2009). Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. Molecular Medicine, 15(1-2), 21-27. https://doi.org/10.2119/molmed.2008.00096

Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. / Drgon, Tomas; Montoya, Ivan; Johnson, Catherine; Liu, Qing Rong; Walther, Donna; Hamer, Dean; Uhl, George R.

In: Molecular Medicine, Vol. 15, No. 1-2, 01.2009, p. 21-27.

Research output: Contribution to journalArticle

Drgon, T, Montoya, I, Johnson, C, Liu, QR, Walther, D, Hamer, D & Uhl, GR 2009, 'Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers', Molecular Medicine, vol. 15, no. 1-2, pp. 21-27. https://doi.org/10.2119/molmed.2008.00096
Drgon, Tomas ; Montoya, Ivan ; Johnson, Catherine ; Liu, Qing Rong ; Walther, Donna ; Hamer, Dean ; Uhl, George R. / Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. In: Molecular Medicine. 2009 ; Vol. 15, No. 1-2. pp. 21-27.
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