Genome-wide association for methamphetamine dependence: Convergent results from 2 samples

George R. Uhl, Tomas Drgon, Qing Rong Liu, Catherine Johnson, Donna Walther, Tokutaro Komiyama, Mutsuo Harano, Yoshimoto Sekine, Toshiya Inada, Norio Ozaki, Masaomi Iyo, Nakao Iwata, Mitsuhiko Yamada, Ichiro Sora, Chih Ken Chen, Hsing Cheng Liu, Hiroshi Ujike, Shih Ku Lin

Research output: Contribution to journalArticle

Abstract

Context: We can improve understanding of human methamphetamine dependence, and possibly our abilities to prevent and treat this devastating disorder, by identifying genes whose allelic variants predispose to methamphetamine dependence. Objective: To find "methamphetamine dependence" genes identified by each of 2 genome-wide association (GWA) studies of independent samples of methamphetamine-dependent individuals and matched controls. Design: Replicated GWA results in each of 2 casecontrol studies. Setting: Japan and Taiwan. Participants: Individuals with methamphetamine dependence and matched control subjects free from psychiatric, substance abuse, or substance dependence diagnoses (N=580). Main Outcome Measures: "Methamphetamine dependence" genes that were reproducibly identified by clusters of nominally positive single-nucleotide polymorphisms (SNPs) in both samples in ways that were unlikely to represent chance observations, based on Monte Carlo simulations that corrected for multiple comparisons, and subsets of "methamphetamine dependence" genes that were also identified by GWA studies of dependence on other addictive substances, success in quitting smoking, and memory. Results: Genes identified by clustered nominally positive SNPs from both samples were unlikely to represent chance observations (Monte Carlo P

Original languageEnglish (US)
Pages (from-to)345-385
Number of pages41
JournalArchives of General Psychiatry
Volume65
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Uhl, G. R., Drgon, T., Liu, Q. R., Johnson, C., Walther, D., Komiyama, T., Harano, M., Sekine, Y., Inada, T., Ozaki, N., Iyo, M., Iwata, N., Yamada, M., Sora, I., Chen, C. K., Liu, H. C., Ujike, H., & Lin, S. K. (2008). Genome-wide association for methamphetamine dependence: Convergent results from 2 samples. Archives of General Psychiatry, 65(3), 345-385. https://doi.org/10.1001/archpsyc.65.3.345