Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D

Motomichi Matsuzaki, Osami Misumi, Tadasu Shin-I, Shinichiro Maruyama, Manabu Takahara, Shin Ya Miyagishima, Toshiyuki Mori, Keiji Nishida, Fumi Yagisawa, Keishin Nishida, Yamato Yoshida, Yoshiki Nishimura, Shunsuke Nakao, Tamaki Kobayashi, Yu Momoyama, Tetsuya Higashiyama, Ayumi Minoda, Masako Sano, Hisayo Nomoto, Kazuko OishiHiroko Hayashi, Fumiko Ohta, Satoko Nishizaka, Shinobu Haga, Sachiko Miura, Tomomi Morishita, Yukihiro Kabeya, Kimihiro Terasawa, Yutaka Suzuki, Yasuyaki Ishii, Shuichi Asakawa, Hiroyoshi Takano, Niji Ohta, Haruko Kuroiwa, Kan Tanaka, Nobuyoshi Shimizu, Sumio Sugano, Naoki Sato, Hisayoshi Nozaki, Naotake Ogasawara, Yuji Kohara, Tsuneyoshi Kuroiwa

Research output: Contribution to journalArticle

Abstract

Small, compact genomes of ultrasmall unicellular algae provide information on the basic and essential genes that support the lives of photosynthetic eukaryotes, including higher plants. Here we report the 16,520,305-base-pair sequence of the 20 chromosomes of the unicellular red alga Cyanidioschyzon merolae 10D as the first complete algal genome. We identified 5,331 genes in total, of which at least 86.3% were expressed. Unique characteristics of this genomic structure include: a lack of introns in all but 26 genes; only three copies of ribosomal DNA units that maintain the nucleolus; and two dynamin genes that are involved only in the division of mitochondria and plastids. The conserved mosaic origin of Calvin cycle enzymes in this red alga and in green plants supports the hypothesis of the existence of single primary plastid endosymbiosis. The lack of a myosin gene, in addition to the unexpressed actin gene, suggests a simpler system of cytokinesis. These results indicate that the C. merolae genome provides a model system with a simple gene composition for studying the origin, evolution and fundamental mechanisms of eukaryotic cells.

Original languageEnglish (US)
Pages (from-to)653-657
Number of pages5
JournalNature
Volume428
Issue number6983
DOIs
StatePublished - Apr 8 2004

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    Matsuzaki, M., Misumi, O., Shin-I, T., Maruyama, S., Takahara, M., Miyagishima, S. Y., Mori, T., Nishida, K., Yagisawa, F., Nishida, K., Yoshida, Y., Nishimura, Y., Nakao, S., Kobayashi, T., Momoyama, Y., Higashiyama, T., Minoda, A., Sano, M., Nomoto, H., ... Kuroiwa, T. (2004). Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D. Nature, 428(6983), 653-657. https://doi.org/10.1038/nature02398