Genome sequence of herpes simplex virus 1 strain mckrae

Stuart J. Macdonald, Heba H. Mostafa, Lynda A. Morrison, David J. Davido

Research output: Contribution to journalComment/debatepeer-review

Abstract

The herpes simplex virus 1 (HSV-1) strain McKrae is highly virulent compared to other wild-type strains of HSV-1. To help us better understand the genetic determinants that lead to differences in the pathogenicity of McKrae and other HSV-1 strains, we sequenced its genome. Comparing the sequence of McKrae's genome to that of strain 17 revealed that the genomes differ by at least 752 single nucleotide polymorphisms (SNPs) and 86 insertion/deletion events (indels). Although the majority of these polymorphisms reside in noncoding regions, 241 SNPs and 10 indels alter the protein-coding sequences of 58 open reading frames. Some of these variations are expected to contribute to the pathogenic phenotype of McKrae.

Original languageEnglish (US)
Pages (from-to)9540-9541
Number of pages2
JournalJournal of virology
Volume86
Issue number17
DOIs
StatePublished - Sep 2012
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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