TY - JOUR
T1 - Genome sequence of herpes simplex virus 1 strain KOS
AU - MacDonald, Stuart J.
AU - Mostafa, Heba H.
AU - Morrison, Lynda A.
AU - Davido, David J.
PY - 2012/6
Y1 - 2012/6
N2 - Herpes simplex virus type 1 (HSV-1) strain KOS has been extensively used in many studies to examine HSV-1 replication, gene expression, and pathogenesis. Notably, strain KOS is known to be less pathogenic than the first sequenced genome of HSV-1, strain 17. To understand the genotypic differences between KOS and other phenotypically distinct strains of HSV-1, we sequenced the viral genome of strain KOS. When comparing strain KOS to strain 17, there are at least 1,024 small nucleotide polymorphisms (SNPs) and 172 insertions/deletions (indels). The polymorphisms observed in the KOS genome will likely provide insights into the genes, their protein products, and the cis elements that regulate the biology of this HSV-1 strain.
AB - Herpes simplex virus type 1 (HSV-1) strain KOS has been extensively used in many studies to examine HSV-1 replication, gene expression, and pathogenesis. Notably, strain KOS is known to be less pathogenic than the first sequenced genome of HSV-1, strain 17. To understand the genotypic differences between KOS and other phenotypically distinct strains of HSV-1, we sequenced the viral genome of strain KOS. When comparing strain KOS to strain 17, there are at least 1,024 small nucleotide polymorphisms (SNPs) and 172 insertions/deletions (indels). The polymorphisms observed in the KOS genome will likely provide insights into the genes, their protein products, and the cis elements that regulate the biology of this HSV-1 strain.
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U2 - 10.1128/JVI.00646-12
DO - 10.1128/JVI.00646-12
M3 - Comment/debate
C2 - 22570244
AN - SCOPUS:84863568603
VL - 86
SP - 6371
EP - 6372
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 11
ER -