Genome sequence of herpes simplex virus 1 strain KOS

Stuart J. MacDonald, Heba H. Mostafa, Lynda A. Morrison, David J. Davido

Research output: Contribution to journalComment/debatepeer-review

Abstract

Herpes simplex virus type 1 (HSV-1) strain KOS has been extensively used in many studies to examine HSV-1 replication, gene expression, and pathogenesis. Notably, strain KOS is known to be less pathogenic than the first sequenced genome of HSV-1, strain 17. To understand the genotypic differences between KOS and other phenotypically distinct strains of HSV-1, we sequenced the viral genome of strain KOS. When comparing strain KOS to strain 17, there are at least 1,024 small nucleotide polymorphisms (SNPs) and 172 insertions/deletions (indels). The polymorphisms observed in the KOS genome will likely provide insights into the genes, their protein products, and the cis elements that regulate the biology of this HSV-1 strain.

Original languageEnglish (US)
Pages (from-to)6371-6372
Number of pages2
JournalJournal of virology
Volume86
Issue number11
DOIs
StatePublished - Jun 2012
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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