Genome scan on fifty-six multiplex bipolar pedigrees collected by the NIMH Genetics Initiative (Bipolar Disorder)

V. L. Willour, P. P. Zandi, E. S. Gershon, J. I. Nurnberger, T. Reich, J. R. Depaulo, M. G. McInnis

    Research output: Contribution to journalArticle

    Abstract

    The NIMH Genetics Initiative (Bipolar Disorder) has ascertained 153 multiplex bipolar pedigrees that have been genotyped in two waves. The results of the wave one analyses have been reported (Nurnberger et al., 1997). We are now reporting the wave two genome scan results for the twelve chromosomes that Johns Hopkins has genotyped: chromosomes 2, 4, 7, 9, 11, 13, 14, 18, 19, 20, 21, and X. The microsatellite marker maps range from 5.8 cM (chromosome X) to 10.3 cM (chromosome 7). Three affection status models (ASM I-III) were used in the linkage analyses. Multipoint nonparametric analyses using GENEHUNTER v 2.0 and XGENEHUNTER v 1.3 produced three candidate regions. A broad peak that spans 4q32-4q35 is visible under all affection status models; it reaches its maximum NPL of 2.70 (P = 0.005) under ASM III. The broad peak at 20p12 reaches an NPL of 2.63 (P = 0.006) under ASM III. The 11p15 peak reaches an NPL 2.42 (P = 0.006) under ASM II. All three of these regions have been previously implicated in bipolar disorder. Continued high-density genetic mapping in these regions is warranted.

    Original languageEnglish (US)
    Number of pages1
    JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
    Volume105
    Issue number7
    StatePublished - Oct 8 2001

    ASJC Scopus subject areas

    • Genetics(clinical)
    • Psychiatry and Mental health
    • Cellular and Molecular Neuroscience

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