Genome scan for tourette disorder in affected-sibling-pair and multigenerational families

David Pauls; D. Cath; P. Heutink; M. Grados; H. S. Singer; J. T. Walkup; C. Illmann; J. M. Scharf; S. Santangelo; S. E. Stewart; J. Platko; D. L. Pauls; N. J. Cox; M. M. Robertson; S. Service; D. Keen-Kim; C. Sabatti; N. Freimer; G. A. Rouleau; J. B. Riviere; S. Chouinard; F. Richer; P. Lesperance; Y. Dion; R. A. King; J. R. Kidd; A. J. Pakstis; J. F. Leckman; K. K. Kidd; G. Gericke; R. Kurlan; P. Como; D. Palumbo; A. Verkerk; B. A. Oostra; W. McMahon; M. Leppert; H. Coon; C. Mathews; P. Sandor; C. L. Barr; C. Betard; D. Zelenika

doi:10.1086/511052

Genome scan for tourette disorder in affected-sibling-pair and multigenerational families

David Pauls, D. Cath, P. Heutink, M. Grados, H. S. Singer, J. T. Walkup, C. Illmann, J. M. Scharf, S. Santangelo, S. E. Stewart, J. Platko, D. L. Pauls, N. J. Cox, M. M. Robertson, S. Service, D. Keen-Kim, C. Sabatti, N. Freimer, G. A. Rouleau, J. B. RiviereS. Chouinard, F. Richer, P. Lesperance, Y. Dion, R. A. King, J. R. Kidd, A. J. Pakstis, J. F. Leckman, K. K. Kidd, G. Gericke, R. Kurlan, P. Como, D. Palumbo, A. Verkerk, B. A. Oostra, W. McMahon, M. Leppert, H. Coon, C. Mathews, P. Sandor, C. L. Barr, C. Betard, D. Zelenika

School of Medicine

Research output: Contribution to journal › Article

Abstract

Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 "independent" sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (- logP = 4.42, P = 3.8 × 10^-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (- logP >2.0) of additional susceptibility loci for TD.

Original language	English (US)
Pages (from-to)	265-272
Number of pages	8
Journal	American journal of human genetics
Volume	80
Issue number	2
DOIs	https://doi.org/10.1086/511052
State	Published - Feb 2007

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1086/511052

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Pauls, D., Cath, D., Heutink, P., Grados, M., Singer, H. S., Walkup, J. T., Illmann, C., Scharf, J. M., Santangelo, S., Stewart, S. E., Platko, J., Pauls, D. L., Cox, N. J., Robertson, M. M., Service, S., Keen-Kim, D., Sabatti, C., Freimer, N., Rouleau, G. A., ... Zelenika, D. (2007). Genome scan for tourette disorder in affected-sibling-pair and multigenerational families. American journal of human genetics, 80(2), 265-272. https://doi.org/10.1086/511052

Genome scan for tourette disorder in affected-sibling-pair and multigenerational families. / Pauls, David; Cath, D.; Heutink, P.; Grados, M.; Singer, H. S.; Walkup, J. T.; Illmann, C.; Scharf, J. M.; Santangelo, S.; Stewart, S. E.; Platko, J.; Pauls, D. L.; Cox, N. J.; Robertson, M. M.; Service, S.; Keen-Kim, D.; Sabatti, C.; Freimer, N.; Rouleau, G. A.; Riviere, J. B.; Chouinard, S.; Richer, F.; Lesperance, P.; Dion, Y.; King, R. A.; Kidd, J. R.; Pakstis, A. J.; Leckman, J. F.; Kidd, K. K.; Gericke, G.; Kurlan, R.; Como, P.; Palumbo, D.; Verkerk, A.; Oostra, B. A.; McMahon, W.; Leppert, M.; Coon, H.; Mathews, C.; Sandor, P.; Barr, C. L.; Betard, C.; Zelenika, D.

In: American journal of human genetics, Vol. 80, No. 2, 02.2007, p. 265-272.

Research output: Contribution to journal › Article

Pauls, D, Cath, D, Heutink, P, Grados, M , Singer, HS, Walkup, JT, Illmann, C, Scharf, JM, Santangelo, S, Stewart, SE, Platko, J, Pauls, DL, Cox, NJ, Robertson, MM, Service, S, Keen-Kim, D, Sabatti, C, Freimer, N, Rouleau, GA, Riviere, JB, Chouinard, S, Richer, F, Lesperance, P, Dion, Y, King, RA, Kidd, JR, Pakstis, AJ, Leckman, JF, Kidd, KK, Gericke, G, Kurlan, R, Como, P, Palumbo, D, Verkerk, A, Oostra, BA, McMahon, W, Leppert, M, Coon, H, Mathews, C, Sandor, P, Barr, CL, Betard, C & Zelenika, D 2007, 'Genome scan for tourette disorder in affected-sibling-pair and multigenerational families', American journal of human genetics, vol. 80, no. 2, pp. 265-272. https://doi.org/10.1086/511052

Pauls, David ; Cath, D. ; Heutink, P. ; Grados, M. ; Singer, H. S. ; Walkup, J. T. ; Illmann, C. ; Scharf, J. M. ; Santangelo, S. ; Stewart, S. E. ; Platko, J. ; Pauls, D. L. ; Cox, N. J. ; Robertson, M. M. ; Service, S. ; Keen-Kim, D. ; Sabatti, C. ; Freimer, N. ; Rouleau, G. A. ; Riviere, J. B. ; Chouinard, S. ; Richer, F. ; Lesperance, P. ; Dion, Y. ; King, R. A. ; Kidd, J. R. ; Pakstis, A. J. ; Leckman, J. F. ; Kidd, K. K. ; Gericke, G. ; Kurlan, R. ; Como, P. ; Palumbo, D. ; Verkerk, A. ; Oostra, B. A. ; McMahon, W. ; Leppert, M. ; Coon, H. ; Mathews, C. ; Sandor, P. ; Barr, C. L. ; Betard, C. ; Zelenika, D. / Genome scan for tourette disorder in affected-sibling-pair and multigenerational families. In: American journal of human genetics. 2007 ; Vol. 80, No. 2. pp. 265-272.

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abstract = "Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 {"}independent{"} sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (- logP = 4.42, P = 3.8 × 10-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (- logP >2.0) of additional susceptibility loci for TD.",

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AU - Illmann, C.

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