Genome scan for tourette disorder in affected-sibling-pair and multigenerational families

David Pauls, D. Cath, P. Heutink, M. Grados, H. S. Singer, J. T. Walkup, C. Illmann, J. M. Scharf, S. Santangelo, S. E. Stewart, J. Platko, D. L. Pauls, N. J. Cox, M. M. Robertson, S. Service, D. Keen-Kim, C. Sabatti, N. Freimer, G. A. Rouleau, J. B. RiviereS. Chouinard, F. Richer, P. Lesperance, Y. Dion, R. A. King, J. R. Kidd, A. J. Pakstis, J. F. Leckman, K. K. Kidd, G. Gericke, R. Kurlan, P. Como, D. Palumbo, A. Verkerk, B. A. Oostra, W. McMahon, M. Leppert, H. Coon, C. Mathews, P. Sandor, C. L. Barr, C. Betard, D. Zelenika

Research output: Contribution to journalArticle

Abstract

Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 "independent" sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (- logP = 4.42, P = 3.8 × 10-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (- logP >2.0) of additional susceptibility loci for TD.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalAmerican journal of human genetics
Volume80
Issue number2
DOIs
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Pauls, D., Cath, D., Heutink, P., Grados, M., Singer, H. S., Walkup, J. T., Illmann, C., Scharf, J. M., Santangelo, S., Stewart, S. E., Platko, J., Pauls, D. L., Cox, N. J., Robertson, M. M., Service, S., Keen-Kim, D., Sabatti, C., Freimer, N., Rouleau, G. A., ... Zelenika, D. (2007). Genome scan for tourette disorder in affected-sibling-pair and multigenerational families. American journal of human genetics, 80(2), 265-272. https://doi.org/10.1086/511052