Genome scan for loci linked to mite sensitivity

The Collaborative Study on the Genetics of Asthma (CSGA)

M. N. Blumenthal, C. Ober, Terri L Beaty, E. R. Bleecker, C. D. Langefeld, R. A. King, L. Lester, N. Cox, K. Barnes, A. Togias, Rasika Mathias, D. A. Meyers, W. Oetting, S. S. Rich, Eva Ehrlich, Linda Freidhoff, Beverly Plunkett, Maria Stockton, Rhonda Peterson, Jennifer Anderson & 10 others Heidi Gidley, Lisa Daniels, Edward Corazalla, Marcia Brott, June Pierce, Mark Brown, Adrienne Hill, Cralen Davis, Tim Howard, Jianfeng Xu

Research output: Contribution to journalArticle

Abstract

Mite sensitivity has been reported to be a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome scan using mite reactivity (Dermatophagoides Pteronyssinus (Der p) and Dermatophagoides farinae (Der f)) as the phenotype was conducted. In 287 CSGA families, 122 were informative for linkage. Evidence supporting linkage was observed for regions on chromosome 19 (D19S591, lod=2.43, P = 0.0008; D19S1037, lod = 1.57, P= 0.007) and chromosome 20 (D20S473/D20S604, lod= 1.41, P= 0.01). All three ethnic groups appeared to contribute to the evidence for linkage on chromosome 20. African-American families gave strongest support for linkage on chromosomes 3 (D3S2409, lod= 1.33, P = 0.01), 12 (D12S373, lod= 1.51, P= 0.008) and 18 (ATA82B02, lod= 1.32, P= 0.01). Caucasian families showed strong evidence for linkage on chromosome 19 (D19S591, lod= 3.51, P = 0.00006). Hispanic families supported linkage on chromosomes 11 (D11S1984, lod= 1.56, P= 0.007), 13 (D13S787, lod= 1.30, P= 0.01) and 20 (D20S470, lod= 1.71, P= 0.005). These results suggest that multiple genes may be involved in controlling skin reactivity to Dermatophoigoies.

Original languageEnglish (US)
Pages (from-to)226-231
Number of pages6
JournalGenes and Immunity
Volume5
Issue number3
DOIs
StatePublished - May 2004

Fingerprint

Mites
Asthma
Genome
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 19
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 3
Hispanic Americans
Ethnic Groups
African Americans
Phenotype
Skin
Genes

Keywords

  • Asthma
  • Atopy
  • Genome scan
  • Mite sensitivity

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Genome scan for loci linked to mite sensitivity : The Collaborative Study on the Genetics of Asthma (CSGA). / Blumenthal, M. N.; Ober, C.; Beaty, Terri L; Bleecker, E. R.; Langefeld, C. D.; King, R. A.; Lester, L.; Cox, N.; Barnes, K.; Togias, A.; Mathias, Rasika; Meyers, D. A.; Oetting, W.; Rich, S. S.; Ehrlich, Eva; Freidhoff, Linda; Plunkett, Beverly; Stockton, Maria; Peterson, Rhonda; Anderson, Jennifer; Gidley, Heidi; Daniels, Lisa; Corazalla, Edward; Brott, Marcia; Pierce, June; Brown, Mark; Hill, Adrienne; Davis, Cralen; Howard, Tim; Xu, Jianfeng.

In: Genes and Immunity, Vol. 5, No. 3, 05.2004, p. 226-231.

Research output: Contribution to journalArticle

Blumenthal, MN, Ober, C, Beaty, TL, Bleecker, ER, Langefeld, CD, King, RA, Lester, L, Cox, N, Barnes, K, Togias, A, Mathias, R, Meyers, DA, Oetting, W, Rich, SS, Ehrlich, E, Freidhoff, L, Plunkett, B, Stockton, M, Peterson, R, Anderson, J, Gidley, H, Daniels, L, Corazalla, E, Brott, M, Pierce, J, Brown, M, Hill, A, Davis, C, Howard, T & Xu, J 2004, 'Genome scan for loci linked to mite sensitivity: The Collaborative Study on the Genetics of Asthma (CSGA)', Genes and Immunity, vol. 5, no. 3, pp. 226-231. https://doi.org/10.1038/sj.gene.6364063
Blumenthal, M. N. ; Ober, C. ; Beaty, Terri L ; Bleecker, E. R. ; Langefeld, C. D. ; King, R. A. ; Lester, L. ; Cox, N. ; Barnes, K. ; Togias, A. ; Mathias, Rasika ; Meyers, D. A. ; Oetting, W. ; Rich, S. S. ; Ehrlich, Eva ; Freidhoff, Linda ; Plunkett, Beverly ; Stockton, Maria ; Peterson, Rhonda ; Anderson, Jennifer ; Gidley, Heidi ; Daniels, Lisa ; Corazalla, Edward ; Brott, Marcia ; Pierce, June ; Brown, Mark ; Hill, Adrienne ; Davis, Cralen ; Howard, Tim ; Xu, Jianfeng. / Genome scan for loci linked to mite sensitivity : The Collaborative Study on the Genetics of Asthma (CSGA). In: Genes and Immunity. 2004 ; Vol. 5, No. 3. pp. 226-231.
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AU - Ober, C.

AU - Beaty, Terri L

AU - Bleecker, E. R.

AU - Langefeld, C. D.

AU - King, R. A.

AU - Lester, L.

AU - Cox, N.

AU - Barnes, K.

AU - Togias, A.

AU - Mathias, Rasika

AU - Meyers, D. A.

AU - Oetting, W.

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AU - Ehrlich, Eva

AU - Freidhoff, Linda

AU - Plunkett, Beverly

AU - Stockton, Maria

AU - Peterson, Rhonda

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AU - Daniels, Lisa

AU - Corazalla, Edward

AU - Brott, Marcia

AU - Pierce, June

AU - Brown, Mark

AU - Hill, Adrienne

AU - Davis, Cralen

AU - Howard, Tim

AU - Xu, Jianfeng

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N2 - Mite sensitivity has been reported to be a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome scan using mite reactivity (Dermatophagoides Pteronyssinus (Der p) and Dermatophagoides farinae (Der f)) as the phenotype was conducted. In 287 CSGA families, 122 were informative for linkage. Evidence supporting linkage was observed for regions on chromosome 19 (D19S591, lod=2.43, P = 0.0008; D19S1037, lod = 1.57, P= 0.007) and chromosome 20 (D20S473/D20S604, lod= 1.41, P= 0.01). All three ethnic groups appeared to contribute to the evidence for linkage on chromosome 20. African-American families gave strongest support for linkage on chromosomes 3 (D3S2409, lod= 1.33, P = 0.01), 12 (D12S373, lod= 1.51, P= 0.008) and 18 (ATA82B02, lod= 1.32, P= 0.01). Caucasian families showed strong evidence for linkage on chromosome 19 (D19S591, lod= 3.51, P = 0.00006). Hispanic families supported linkage on chromosomes 11 (D11S1984, lod= 1.56, P= 0.007), 13 (D13S787, lod= 1.30, P= 0.01) and 20 (D20S470, lod= 1.71, P= 0.005). These results suggest that multiple genes may be involved in controlling skin reactivity to Dermatophoigoies.

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