Genome-scale models of microbial cells: Evaluating the consequences of constraints

Nathan D. Price, Jennifer L. Reed, Bernhard Palsson

Research output: Contribution to journalReview articlepeer-review

Abstract

Microbial cells operate under governing constraints that limit their range of possible functions. With the availability of annotated genome sequences, it has become possible to reconstruct genome-scale biochemical reaction networks for microorganisms. The imposition of governing constraints on a reconstructed biochemical network leads to the definition of achievable cellular functions. In recent years, a substantial and growing toolbox of computational analysis methods has been developed to study the characteristics and capabilities of microorganisms using a constraint-based reconstruction and analysis (COBRA) approach. This approach provides a biochemically and genetically consistent framework for the generation of hypotheses and the testing of functions of microbial cells.

Original languageEnglish (US)
Pages (from-to)886-897
Number of pages12
JournalNature Reviews Microbiology
Volume2
Issue number11
DOIs
StatePublished - Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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