Genome evolution in yeast reveals connections between rare mutations in human cancers

Xinchen Teng; J. Marie Hardwick

doi:10.15698/mic2014.06.153

Genome evolution in yeast reveals connections between rare mutations in human cancers

Xinchen Teng, J. Marie Hardwick

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.

Original language	English (US)
Pages (from-to)	206-209
Number of pages	4
Journal	Microbial Cell
Volume	1
Issue number	6
DOIs	https://doi.org/10.15698/mic2014.06.153
State	Published - Jun 2014

Keywords

Cancer progression
Genome evolution
Secondary mutations
Yeast knockouts

ASJC Scopus subject areas

Immunology and Microbiology (miscellaneous)
Biochemistry, Genetics and Molecular Biology (miscellaneous)

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10.15698/mic2014.06.153

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title = "Genome evolution in yeast reveals connections between rare mutations in human cancers",

abstract = "Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.",

keywords = "Cancer progression, Genome evolution, Secondary mutations, Yeast knockouts",

author = "Xinchen Teng and Hardwick, {J. Marie}",

note = "Funding Information: This work was supported by the National Institutes of Health USA NS037402, NS083373, and GM077875 (J.M.H.). Publisher Copyright: {\textcopyright} 2014 Teng and Hardwick.",

year = "2014",

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language = "English (US)",

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AU - Teng, Xinchen

AU - Hardwick, J. Marie

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N2 - Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.

AB - Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.

KW - Cancer progression

KW - Genome evolution

KW - Secondary mutations

KW - Yeast knockouts

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DO - 10.15698/mic2014.06.153

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Genome evolution in yeast reveals connections between rare mutations in human cancers

Abstract

Keywords

ASJC Scopus subject areas

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