Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.
- Cancer progression
- Genome evolution
- Secondary mutations
- Yeast knockouts
ASJC Scopus subject areas
- Immunology and Microbiology (miscellaneous)
- Biochemistry, Genetics and Molecular Biology (miscellaneous)