Genome analysis linking recent European and African influenza (H5N1) viruses

Steven L Salzberg, Carl Kingsford, Giovanni Cattoli, David J. Spiro, Daniel A. Janies, Mona Mehrez Aly, Ian H. Brown, Emmanuel Couacy-Hymann, Gian Mario De Mia, Huu Dung Do, Annalisa Guercio, Tony Joannis, Ali Safar Maken Ali, Azizullah Osmani, Iolanda Padalino, Magdi D. Saad, Vladimir Savić, Naomi A. Sengamalay, Samuel Yingst, Jennifer Zaborsky & 3 others Olga Zorman-Rojs, Elodie Ghedin, Ilaria Capua

Research output: Contribution to journalArticle

Abstract

To better understand the ecology and epidemiology of the highly pathogenic avian influenza virus in its transcontinental spread, we sequenced and analyzed the complete genomes of 36 recent influenza A (H5N1) viruses collected from birds in Europe, northern Africa, and southeastern Asia. These sequences, among the first complete genomes of influenza (H5N1) viruses outside Asia, clearly depict the lineages now infecting wild and domestic birds in Europe and Africa and show the relationships among these isolates and other strains affecting both birds and humans. The isolates fall into 3 distinct lineages, 1 of which contains all known non-Asian isolates. This new Euro-African lineage, which was the cause of several recent (2006) fatal human infections in Egypt and Iraq, has been introduced at least 3 times into the European-African region and has split into 3 distinct, independently evolving sublineages. One isolate provides evidence that 2 of these sublineages have recently reassorted.

Original languageEnglish (US)
Pages (from-to)713-718
Number of pages6
JournalEmerging Infectious Diseases
Volume13
Issue number5
StatePublished - May 2007
Externally publishedYes

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H5N1 Subtype Influenza A Virus
Orthomyxoviridae
Birds
Genome
Northern Asia
Northern Africa
Iraq
Southeastern Asia
Influenza in Birds
Egypt
Influenza A virus
Ecology
Epidemiology
Infection

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Salzberg, S. L., Kingsford, C., Cattoli, G., Spiro, D. J., Janies, D. A., Aly, M. M., ... Capua, I. (2007). Genome analysis linking recent European and African influenza (H5N1) viruses. Emerging Infectious Diseases, 13(5), 713-718.

Genome analysis linking recent European and African influenza (H5N1) viruses. / Salzberg, Steven L; Kingsford, Carl; Cattoli, Giovanni; Spiro, David J.; Janies, Daniel A.; Aly, Mona Mehrez; Brown, Ian H.; Couacy-Hymann, Emmanuel; De Mia, Gian Mario; Do, Huu Dung; Guercio, Annalisa; Joannis, Tony; Ali, Ali Safar Maken; Osmani, Azizullah; Padalino, Iolanda; Saad, Magdi D.; Savić, Vladimir; Sengamalay, Naomi A.; Yingst, Samuel; Zaborsky, Jennifer; Zorman-Rojs, Olga; Ghedin, Elodie; Capua, Ilaria.

In: Emerging Infectious Diseases, Vol. 13, No. 5, 05.2007, p. 713-718.

Research output: Contribution to journalArticle

Salzberg, SL, Kingsford, C, Cattoli, G, Spiro, DJ, Janies, DA, Aly, MM, Brown, IH, Couacy-Hymann, E, De Mia, GM, Do, HD, Guercio, A, Joannis, T, Ali, ASM, Osmani, A, Padalino, I, Saad, MD, Savić, V, Sengamalay, NA, Yingst, S, Zaborsky, J, Zorman-Rojs, O, Ghedin, E & Capua, I 2007, 'Genome analysis linking recent European and African influenza (H5N1) viruses', Emerging Infectious Diseases, vol. 13, no. 5, pp. 713-718.
Salzberg SL, Kingsford C, Cattoli G, Spiro DJ, Janies DA, Aly MM et al. Genome analysis linking recent European and African influenza (H5N1) viruses. Emerging Infectious Diseases. 2007 May;13(5):713-718.
Salzberg, Steven L ; Kingsford, Carl ; Cattoli, Giovanni ; Spiro, David J. ; Janies, Daniel A. ; Aly, Mona Mehrez ; Brown, Ian H. ; Couacy-Hymann, Emmanuel ; De Mia, Gian Mario ; Do, Huu Dung ; Guercio, Annalisa ; Joannis, Tony ; Ali, Ali Safar Maken ; Osmani, Azizullah ; Padalino, Iolanda ; Saad, Magdi D. ; Savić, Vladimir ; Sengamalay, Naomi A. ; Yingst, Samuel ; Zaborsky, Jennifer ; Zorman-Rojs, Olga ; Ghedin, Elodie ; Capua, Ilaria. / Genome analysis linking recent European and African influenza (H5N1) viruses. In: Emerging Infectious Diseases. 2007 ; Vol. 13, No. 5. pp. 713-718.
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