Genital warts, papillomaviruses, and genital malignancies

K. V. Shah, J. Buscema

Research output: Contribution to journalReview articlepeer-review

Abstract

Human papillomavirus (HPV) infections of the genital tract are widespread and often subclinical. Of about a dozen genital tract HPVs, types 16 and 18 are strongly associated with squamous cell carcinoma of the cervix and of other sites in the lower genital tract. In invasive cervical cancers, the viral genomes are often integrated into the cellular DNA and are transcriptionally active. These viruses, with additional cofactors, play a role in genital tract malignancies.

Original languageEnglish (US)
Pages (from-to)371-379
Number of pages9
JournalAnnual review of medicine
Volume39
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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