Genital warts and cervical cancer. VI. The relationship between aneuploid and polyploid

R. Reid, Y. S. Fu, B. R. Herschman, C. P. Crum, L. Braun, K. V. Shah, S. J. Agronow, C. R. Stanhope

Research output: Contribution to journalArticle

Abstract

Human papillomaviral infection is now widely implicated in the causation of cervical neoplasia. Genotype analysis provides the best guide to biologic outcome; most polyploid lesions regress and most aneuploid ones persist or progress. This prospective survey examined the relationships between cell ploidy and 24 objectively validated criteria of human papillomaviral infection or premalignant change in 52 biopsies from a dysplasia clinic. Histologic evidence of benign warty expression and human papillomaviral capsid antigen production decreased steadily as DNA content ranged from diploidy to polyploid to aneuploid. In contrast, premalignant change increased with progressive distortion of nuclear DNA content. No absolute discriminants were found between polyploid and aneuploidy, as evidence by the detection of human papillomaviral proteins in three of 21 aneuploid epithelia and the recognition of abnormal mitotic figures in five of 17 polyploid lesions. Polyploid and aneuploid lesions differed only in severity, and it appears that some polyploid epithelia may be transition forms between diploidy and aneuploidy.

Original languageEnglish (US)
Pages (from-to)189-199
Number of pages11
JournalAmerican Journal of Obstetrics and Gynecology
Volume150
Issue number2
StatePublished - 1984

Fingerprint

Condylomata Acuminata
Polyploidy
Aneuploidy
Uterine Cervical Neoplasms
Diploidy
Epithelium
Ploidies
Capsid
DNA
Infection
Causality
Genotype
Biopsy
Antigens
Neoplasms
Proteins

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Reid, R., Fu, Y. S., Herschman, B. R., Crum, C. P., Braun, L., Shah, K. V., ... Stanhope, C. R. (1984). Genital warts and cervical cancer. VI. The relationship between aneuploid and polyploid. American Journal of Obstetrics and Gynecology, 150(2), 189-199.

Genital warts and cervical cancer. VI. The relationship between aneuploid and polyploid. / Reid, R.; Fu, Y. S.; Herschman, B. R.; Crum, C. P.; Braun, L.; Shah, K. V.; Agronow, S. J.; Stanhope, C. R.

In: American Journal of Obstetrics and Gynecology, Vol. 150, No. 2, 1984, p. 189-199.

Research output: Contribution to journalArticle

Reid, R, Fu, YS, Herschman, BR, Crum, CP, Braun, L, Shah, KV, Agronow, SJ & Stanhope, CR 1984, 'Genital warts and cervical cancer. VI. The relationship between aneuploid and polyploid', American Journal of Obstetrics and Gynecology, vol. 150, no. 2, pp. 189-199.
Reid, R. ; Fu, Y. S. ; Herschman, B. R. ; Crum, C. P. ; Braun, L. ; Shah, K. V. ; Agronow, S. J. ; Stanhope, C. R. / Genital warts and cervical cancer. VI. The relationship between aneuploid and polyploid. In: American Journal of Obstetrics and Gynecology. 1984 ; Vol. 150, No. 2. pp. 189-199.
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