@article{28b63ada242c4db7a03c404f0fa8739a,
title = "Genital warts and cervical cancer: VI. The relationship between aneuploid and polyploid cervical lesions",
abstract = "Human papillomaviral infection is now widely implicated in the causation of cervical neoplasia. Genotype analysis provides the best guide to biologic outcome; most polyploid lesions regress and most aneuploid ones persist or progress. This prospective survey examined the relationships between cell ploidy and 24 objectively validated criteria of human papillomaviral infection or premalignant change in 52 biopsies from a dysplasia clinic. Histologic evidence of benign warty expression and human papillomaviral capsid antigen production decreased steadily as DNA content ranged from diploidy to polyploidy to aneuploidy. In contrast, premalignant change increased with progressive distortion of nuclear DNA content. No absolute discriminants were found between polyploidy and aneuploidy, as evidenced by the detection of human papillomaviral proteins in three of 21 aneuploid epithelia and the recognition of abnormal mitotic figures in five of 17 polyploid lesions. Polyploid and aneuploid lesions differed only in severity, and it appears that some polyploid epithelia may be transition forms between diploidy and aneuploidy.",
author = "Richard Reid and Fu, {Yao Shi} and Herschman, {Barry R.} and Crum, {Christopher P.} and Lundy Braun and Shah, {Keerti V.} and Agronow, {Samuel J.} and Robert Stanhope",
note = "Funding Information: From the Department ofObstetrics and Gynecology, Sinai Hospital of Detroit, and the C. S. Mott Center for Human Gr:owth and Devel-opment, Wayne State University School of Medicine, Detroit, the Department ofPathology, Providence Hospital, Southfield, the De-partment ofPathology, Center for the Health Sciences, University of California at Los Angeles, the Department of Obstetric and Gy-necologic Pathology, College of Physicians and Surgeons of Co-lumbia University, New York, the Department ofPaihoMology, The Johns Hopkins University, Baltimore, and the Division of Gyneco-logic Surgery, Mayo Clinic and Mayo Foundation, Rochester. Supported in part by Grant CA22453 from the Michigan Cancer Foundation, by Grant 24932 from the National Cancer Institute, Department of Health and Human Services, and Grant 1 POI AI 16959 from the National Institutes of Health. Received for publication January 13, 1984; revised March 28, 1984; accepted April3, 1984. Reprint requests: Richard Reid, M.D., Department of Obstetrics and Gynecology, Sinai Hospital ofDetroit; 6767 West Outer Dr., De-troit, MI 48235.",
year = "1984",
doi = "10.1016/S0002-9378(84)80015-0",
language = "English (US)",
volume = "150",
pages = "189--199",
journal = "American journal of obstetrics and gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",
}