TY - JOUR
T1 - Genital warts and cervical cancer. V. The tissue basis of colposcopic change
AU - Reid, Richard
AU - Herschman, Barry R.
AU - Crum, Christopher P.
AU - Fu, Yao Shi
AU - Braun, Lundy
AU - Shah, Keerti V.
AU - Agronow, Samuel J.
AU - Stanhope, C. Robert
N1 - Funding Information:
Supported in part by Grant No. CA22453 from the Michigan Cancer Foundation, Grant No. 24932 from the National Cancer Institute, Department of Health and Human Services, and Grant No. POl AI 16959 from the National Institutes of Health.
PY - 1984/6/1
Y1 - 1984/6/1
N2 - Histologic differences between subclinical papillomaviral infection and cervical intraepithelial neoplasia are quantitative rather than qualitative. Both entities are characterized colposcopically by acetowhite epithelium and aberrant surface capillaries. This study correlates five new colposcopic signs (variations in contour, thickness, color, vascular patterns, and iodine staining) with 12 histologic signs of human papillomaviral infection and 12 features of premalignant change. Acetowhitening and capillary abnormalities in minor colposcopic lesions are attributable to human papillomaviral disturbance of cell growth and maturation, seen histologically as parabasal layer proliferation, papillomatosis, koilocytosis, and dyskeratosis. Alteration in cell ploidy is usually minimal. Major colposcopic abnormalities reflect extensive disorganization of cell phenotype and tissue architecture, increased DNA content, and aneuploid stem cell populations. Intermediate colposcopic patterns generally denote polyploid lesions in which tissue changes are a composite of two reciprocal events: the extent of benign warty expression and the severity of premalignant change.
AB - Histologic differences between subclinical papillomaviral infection and cervical intraepithelial neoplasia are quantitative rather than qualitative. Both entities are characterized colposcopically by acetowhite epithelium and aberrant surface capillaries. This study correlates five new colposcopic signs (variations in contour, thickness, color, vascular patterns, and iodine staining) with 12 histologic signs of human papillomaviral infection and 12 features of premalignant change. Acetowhitening and capillary abnormalities in minor colposcopic lesions are attributable to human papillomaviral disturbance of cell growth and maturation, seen histologically as parabasal layer proliferation, papillomatosis, koilocytosis, and dyskeratosis. Alteration in cell ploidy is usually minimal. Major colposcopic abnormalities reflect extensive disorganization of cell phenotype and tissue architecture, increased DNA content, and aneuploid stem cell populations. Intermediate colposcopic patterns generally denote polyploid lesions in which tissue changes are a composite of two reciprocal events: the extent of benign warty expression and the severity of premalignant change.
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U2 - 10.1016/0002-9378(84)90229-1
DO - 10.1016/0002-9378(84)90229-1
M3 - Article
C2 - 6328996
AN - SCOPUS:0021245016
SN - 0002-9378
VL - 149
SP - 293
EP - 303
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 3
ER -