Genital tract sequestration of SIV following acute infection

James B. Whitney, Peter T. Hraber, Corinne Luedemann, Elena E. Giorgi, Marcus G. Daniels, Tanmoy Bhattacharya, Srinivas S. Rao, John R. Mascola, Gary J. Nabel, Bette T. Korber, Norman L. Letvin

Research output: Contribution to journalArticle

Abstract

We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.

Original languageEnglish (US)
Article numbere1001293
JournalPLoS Pathogens
Volume7
Issue number2
DOIs
StatePublished - Feb 2011
Externally publishedYes

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Simian Immunodeficiency Virus
Viremia
Virus Replication
Viruses
Semen
Infection
Satellite Viruses
Gene Flow
Macaca mulatta
Haplorhini

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Cite this

Whitney, J. B., Hraber, P. T., Luedemann, C., Giorgi, E. E., Daniels, M. G., Bhattacharya, T., ... Letvin, N. L. (2011). Genital tract sequestration of SIV following acute infection. PLoS Pathogens, 7(2), [e1001293]. https://doi.org/10.1371/journal.ppat.1001293

Genital tract sequestration of SIV following acute infection. / Whitney, James B.; Hraber, Peter T.; Luedemann, Corinne; Giorgi, Elena E.; Daniels, Marcus G.; Bhattacharya, Tanmoy; Rao, Srinivas S.; Mascola, John R.; Nabel, Gary J.; Korber, Bette T.; Letvin, Norman L.

In: PLoS Pathogens, Vol. 7, No. 2, e1001293, 02.2011.

Research output: Contribution to journalArticle

Whitney, JB, Hraber, PT, Luedemann, C, Giorgi, EE, Daniels, MG, Bhattacharya, T, Rao, SS, Mascola, JR, Nabel, GJ, Korber, BT & Letvin, NL 2011, 'Genital tract sequestration of SIV following acute infection', PLoS Pathogens, vol. 7, no. 2, e1001293. https://doi.org/10.1371/journal.ppat.1001293
Whitney JB, Hraber PT, Luedemann C, Giorgi EE, Daniels MG, Bhattacharya T et al. Genital tract sequestration of SIV following acute infection. PLoS Pathogens. 2011 Feb;7(2). e1001293. https://doi.org/10.1371/journal.ppat.1001293
Whitney, James B. ; Hraber, Peter T. ; Luedemann, Corinne ; Giorgi, Elena E. ; Daniels, Marcus G. ; Bhattacharya, Tanmoy ; Rao, Srinivas S. ; Mascola, John R. ; Nabel, Gary J. ; Korber, Bette T. ; Letvin, Norman L. / Genital tract sequestration of SIV following acute infection. In: PLoS Pathogens. 2011 ; Vol. 7, No. 2.
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