Genital tract sequestration of SIV following acute infection

James B. Whitney, Peter T. Hraber, Corinne Luedemann, Elena E. Giorgi, Marcus G. Daniels, Tanmoy Bhattacharya, Srinivas S. Rao, John R. Mascola, Gary J. Nabel, Bette T. Korber, Norman L. Letvin

Research output: Contribution to journalArticle

Abstract

We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.

Original languageEnglish (US)
Article numbere1001293
JournalPLoS pathogens
Volume7
Issue number2
DOIs
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

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    Whitney, J. B., Hraber, P. T., Luedemann, C., Giorgi, E. E., Daniels, M. G., Bhattacharya, T., Rao, S. S., Mascola, J. R., Nabel, G. J., Korber, B. T., & Letvin, N. L. (2011). Genital tract sequestration of SIV following acute infection. PLoS pathogens, 7(2), [e1001293]. https://doi.org/10.1371/journal.ppat.1001293