Genetics of Psychiatric Disorders Methods: Molecular Approaches

Research output: Contribution to journalArticle

Abstract

The practice of psychiatry has long suffered from the limited information available on the biological basis of mental disorders. This limitation is now coming to an end. Advances in DNA analysis technologies and in our understanding of the human genome, together with our new knowledge of the properties of the genome and significant efforts toward generating large patient and control sample collections, have paved the way for successful genome-wide association studies. As a result, reports now appear in the literature every week identifying new genes for complex disorders. Next-generation sequencing methods, combined with the results of association and perhaps linkage studies, will help us uncover missing heritability factors, achieve a better understanding of the genetic aspects of psychiatric disease, and devise the best strategies for incorporating genetics in the service of patients.

Original languageEnglish (US)
Pages (from-to)815-827
Number of pages13
JournalClinics in Laboratory Medicine
Volume30
Issue number4
DOIs
StatePublished - Dec 2010

Fingerprint

Inborn Genetic Diseases
Psychiatry
Genes
Genetic Services
Genome-Wide Association Study
Human Genome
Mental Disorders
Genome
Technology
DNA
Genetics

Keywords

  • Epigenetics
  • Genetic association studies
  • Human Genome Project
  • Linkage analysis
  • Next-generation sequencing methods

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry

Cite this

Genetics of Psychiatric Disorders Methods : Molecular Approaches. / Avramopoulos, Dimitrios.

In: Clinics in Laboratory Medicine, Vol. 30, No. 4, 12.2010, p. 815-827.

Research output: Contribution to journalArticle

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