Genetics of Parkinson's disease and parkinsonism

John Hardy, Huaiban Cai, Mark R. Cookson, Katrina Gwinn-Hardy, Andrew Singleton

Research output: Contribution to journalArticle

Abstract

Until 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of sevetal genes that derive from the loci given the nomenclature PARK1-PARK12 (OMIM 168600). Recently, these research findings have begun to impact clinical practice, and this impact is likely to increase. The primary purpose of this article is to outline these genetic advances, discuss their importance for current practice in clinical and related settings, and outline briefly how they are influencing research into the causes of and possible future treatments for this prevalent disorder.

Original languageEnglish (US)
Pages (from-to)389-398
Number of pages10
JournalAnnals of Neurology
Volume60
Issue number4
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Inborn Genetic Diseases
Parkinsonian Disorders
Parkinson Disease
Genetic Databases
Research
Terminology
Organism Cloning
Genes
Therapeutics
Parkinson Disease 12

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hardy, J., Cai, H., Cookson, M. R., Gwinn-Hardy, K., & Singleton, A. (2006). Genetics of Parkinson's disease and parkinsonism. Annals of Neurology, 60(4), 389-398. https://doi.org/10.1002/ana.21022

Genetics of Parkinson's disease and parkinsonism. / Hardy, John; Cai, Huaiban; Cookson, Mark R.; Gwinn-Hardy, Katrina; Singleton, Andrew.

In: Annals of Neurology, Vol. 60, No. 4, 10.2006, p. 389-398.

Research output: Contribution to journalArticle

Hardy, J, Cai, H, Cookson, MR, Gwinn-Hardy, K & Singleton, A 2006, 'Genetics of Parkinson's disease and parkinsonism', Annals of Neurology, vol. 60, no. 4, pp. 389-398. https://doi.org/10.1002/ana.21022
Hardy J, Cai H, Cookson MR, Gwinn-Hardy K, Singleton A. Genetics of Parkinson's disease and parkinsonism. Annals of Neurology. 2006 Oct;60(4):389-398. https://doi.org/10.1002/ana.21022
Hardy, John ; Cai, Huaiban ; Cookson, Mark R. ; Gwinn-Hardy, Katrina ; Singleton, Andrew. / Genetics of Parkinson's disease and parkinsonism. In: Annals of Neurology. 2006 ; Vol. 60, No. 4. pp. 389-398.
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