Genetics of pancreatic neuroendocrine tumors: Implications for the clinic

Research output: Contribution to journalReview article

Abstract

Pancreatic neuroendocrine tumors (PanNETs) are a common and deadly neoplasm of the pancreas. Although the importance of genetic alterations in PanNETs has been known for many years, recent comprehensive sequencing studies have greatly expanded our knowledge of neuroendocrine tumorigenesis in the pancreas. These studies have identified specific cellular processes that are altered in PanNETs, highlighted alterations with prognostic implications, and pointed to pathways for targeted therapies. In this review, we will discuss the genetic alterations that play a key role in PanNET tumorigenesis, with a specific focus on those alterations with the potential to change the way patients with these neoplasms are diagnosed and treated.

Original languageEnglish (US)
Pages (from-to)1407-1419
Number of pages13
JournalExpert Review of Gastroenterology and Hepatology
Volume9
Issue number11
DOIs
StatePublished - Nov 2 2015

Keywords

  • PanNET
  • genetics
  • islet cell tumor
  • mutation
  • pancreatic neuroendocrine tumor
  • sequencing

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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