TY - JOUR
T1 - Genetics of pancreatic cancer
T2 - From genes to families
AU - Hruban, R. H.
AU - Petersen, G. M.
AU - Ha, P. K.
AU - Kern, S. E.
PY - 1998
Y1 - 1998
N2 - Cancer of the pancreas is a genetic disease. Sporadic cancers of the pancreas are frequently associated with the activation of an oncogene, K- ras, and the inactivation of multiple tumor suppressor genes, including p53, DPC4, p16, and BRCA2. An improved understanding of the genetics of pancreas cancer should lead to new tests to screen for this disease and novel rational gene-based therapies.
AB - Cancer of the pancreas is a genetic disease. Sporadic cancers of the pancreas are frequently associated with the activation of an oncogene, K- ras, and the inactivation of multiple tumor suppressor genes, including p53, DPC4, p16, and BRCA2. An improved understanding of the genetics of pancreas cancer should lead to new tests to screen for this disease and novel rational gene-based therapies.
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U2 - 10.1016/s1055-3207(18)30282-5
DO - 10.1016/s1055-3207(18)30282-5
M3 - Review article
C2 - 9443984
AN - SCOPUS:0031909196
SN - 1055-3207
VL - 7
SP - 1
EP - 23
JO - Surgical Oncology Clinics of North America
JF - Surgical Oncology Clinics of North America
IS - 1
ER -