Genetics of nonsyndromic oral clefts revisited

Diego F. Wyszynski, Terri H. Beaty, Nancy E. Maestri

Research output: Contribution to journalReview articlepeer-review

Abstract

Nonsyndromic oral clefts are among the most common birth defects, affecting approximately 1 in 1000 Caucasian newborns. In recent decades, many investigators have used genetic and epidemiologic methods to identify etiologic factors, but results have often been inconclusive or contradictory. Etiologic heterogeneity is undoubtedly a major component in these birth defects, and there may not be a single answer to this problem. Here, we describe the main features of published studies pointing out their strengths and limitations. Additionally, we give insight into current methods for detecting the presence of interaction between genetic markers and environmental exposures in the etiology of oral clefts.

Original languageEnglish (US)
Pages (from-to)406-417
Number of pages12
JournalCleft Palate-Craniofacial Journal
Volume33
Issue number5
DOIs
StatePublished - Sep 1996

Keywords

  • birth defects
  • cleft lip
  • cleft palate
  • genetics
  • malformations

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology

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