Genetics of inflammatory bowel disease

Amir Karban, Rami Eliakim, Steven R. Brant

Research output: Contribution to journalReview article

Abstract

The etiology of inflammatory bowel diseases, Crohn's disease and ulcerative colitis, is uncertain. Studies of specific environmental factors and immune dysfunction have provided limited insight into disease pathogenesis. There is ample evidence that these diseases are in part the result of genetic predisposition. The early search for candidate genes focused on genes involved in the regulation of immune function. Recent genome-wide searches reported several susceptibility loci for Crohn's disease and ulcerative colitis. The recent identification of the IBD1 gene (NOD2) with mutations that are associated with susceptibility to Crohn's disease will have a major impact on the understanding of the genetics of this disease.

Original languageEnglish (US)
Pages (from-to)798-802
Number of pages5
JournalIsrael Medical Association Journal
Volume4
Issue number10
StatePublished - Oct 1 2002

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Keywords

  • Crohn's disease
  • Genetic counseling
  • Genetics
  • Inflammatory bowel disease
  • NOD2 gene
  • Ulcerative colitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Karban, A., Eliakim, R., & Brant, S. R. (2002). Genetics of inflammatory bowel disease. Israel Medical Association Journal, 4(10), 798-802.