Genetics of Human Anxiety and Its Disorders

A. R. Hariri, D. R. Weinberger

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Normal variation in human emotionality, in temperament and risk for affective disorders, is explained to a large degree by genetic variation. The sequencing of the human genome has made it possible to test the role of specific genes on measures of human emotionality, on risk for affective disorders, and on the brain systems that appear to mediate emotion-related phenotypes. A novel approach, called imaging genetics, has shown that several genes that impact on brain serotonergic signaling affect the development and function of circuits of the limbic system involved in emotional experience and behavior.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages669-677
Number of pages9
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

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Keywords

  • 5HTTLPR
  • Anxiety
  • BDNF
  • Depression
  • FMRI
  • Genetics
  • MAOA
  • Neuroimaging
  • TPH
  • Temperament

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hariri, A. R., & Weinberger, D. R. (2009). Genetics of Human Anxiety and Its Disorders. In Encyclopedia of Neuroscience (pp. 669-677). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00845-7