Genetics of carbon tetrachloride-induced liver injury in mice. II. Multigenic regulation

K. W. Biesel, M. N. Ehrinpreis, P. S. Bhathal, I. R. Mackay, N. R. Rose

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Abstract

Mice from many different congenic inbred strains were given an intramuscular injection of carbon tetrachloride (CCl4) in olive oil to determine the genetic influences on induction of, and recovery from, liver damage. Liver and blood samples were taken at days 1, 4 and 7. The degree of necrosis and lymphoid infiltration appeared to be controlled, qualitatively and quantitatively, by both H-2-linked and Ah-linked genes. Strain differences were noted in the patterns of hepatocellular necrosis and the proportions of lymphoid, monocytic and other inflammatory cells which characterized the infiltrating population. Kinetic studies of F1 hybrids from matings between the susceptible BALB/cJ male parent and the resistant SJL/J female parent suggested that two dominant genetic influences play a major role in liver necrosis and a second gene from SJL/J augments recovery. These results suggest, therefore, that the CCl4-induced liver damage and subsequent recovery are under multigenic control by H-2, Ah and possibly other genes.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalBritish Journal of Experimental Pathology
Volume65
Issue number1
Publication statusPublished - 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Biesel, K. W., Ehrinpreis, M. N., Bhathal, P. S., Mackay, I. R., & Rose, N. R. (1984). Genetics of carbon tetrachloride-induced liver injury in mice. II. Multigenic regulation. British Journal of Experimental Pathology, 65(1), 125-131.