Genetics of arterial prothrombotic risk states

Marlene S. Williams, Paul F. Bray

Research output: Contribution to journalShort surveypeer-review

Abstract

Coronary artery disease is a leading cause of death worldwide and the largest killer of men and women in the United States. The pathophysiology of myocardial infarction is multifactorial, and numerous physiologic systems converge to dictate the formation of the two fundamental lesions, thrombosis and atherosclerosis. In this review we address genetic aspects of arterial thrombosis and the key thrombotic factors that have been associated with the increased risk for its development. Specifically, we consider components of coagulation, fibrinolysis, and platelet adhesive receptors, and we review the genetic epidemiology and in vitro laboratory data regarding their risk for the acute coronary syndromes. In combination with traditional risk factor assessment, in the near future these inherited markers can be used to manage patients with vascular disease through a better utilization of invasive or expensive diagnostic testing, as well as pharmacologic intervention.

Original languageEnglish (US)
Pages (from-to)409-419
Number of pages11
JournalExperimental Biology and Medicine
Volume226
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Coronary artery
  • Genetics
  • Platelets
  • Risk factors
  • Thrombosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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