Genetics of Alzheimer's disease: Recent advances

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease is a progressive neurodegenerative disorder with high prevalence in old age.t is the most common cause of dementia, with a risk reaching 50% after the age of 85 years, and with the increasing age of the population it is one of the biggest healthcare challenges of the 21st century. Genetic variation is an important contributor to the risk for this disease, underlying an estimated heritability of about 70%. Alzheimer's genetics research in the 1990s was successful in identifying three genes accounting for most cases of early-onset disease with autosomal dominant inheritance, and one gene involved in the more common late-onset disease, which shows complex inheritance patterns. Despite the presence of significant remaining genetic contribution to the risk, the identification of genes since then has been elusive, reminiscent of most other complex disorders. In the past decade there have been significant efforts towards a systematic evaluation of the multiple genetic association studies for Alzheimer's disease, while the first genome-wide association studies are now being reported with promising results. As sample sizes grow through new collections and collaborative efforts, and as new technologies make it possible to test alternative hypotheses, it is expected that new genes involved in the disease will soon be identified and confirmed. The gene discoveries of the 1990s have taught us a lot about Alzheimer's disease pathogenesis, providing many therapeutic targets that are currently at various stages of testing for future clinical use. As new genes become known and the biological pathways leading to disease are further explored, the possibility of prevention and successful personalized treatment is becoming tangible, providing hope for the millions of patients with Alzheimer's disease and their caregivers.

Original languageEnglish (US)
Article numbergm34
JournalGenome Medicine
Volume1
Issue number3
DOIs
StatePublished - Mar 27 2009

Fingerprint

Inborn Genetic Diseases
Alzheimer Disease
Genes
Genetic Association Studies
Inheritance Patterns
Genetic Research
Genome-Wide Association Study
Neurodegenerative Diseases
Sample Size
Caregivers
Dementia
Technology
Delivery of Health Care
Therapeutics
Population

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this

Genetics of Alzheimer's disease : Recent advances. / Avramopoulos, Dimitrios.

In: Genome Medicine, Vol. 1, No. 3, gm34, 27.03.2009.

Research output: Contribution to journalArticle

@article{7832194600fd49e3957b9d9a74e1d291,
title = "Genetics of Alzheimer's disease: Recent advances",
abstract = "Alzheimer's disease is a progressive neurodegenerative disorder with high prevalence in old age.t is the most common cause of dementia, with a risk reaching 50{\%} after the age of 85 years, and with the increasing age of the population it is one of the biggest healthcare challenges of the 21st century. Genetic variation is an important contributor to the risk for this disease, underlying an estimated heritability of about 70{\%}. Alzheimer's genetics research in the 1990s was successful in identifying three genes accounting for most cases of early-onset disease with autosomal dominant inheritance, and one gene involved in the more common late-onset disease, which shows complex inheritance patterns. Despite the presence of significant remaining genetic contribution to the risk, the identification of genes since then has been elusive, reminiscent of most other complex disorders. In the past decade there have been significant efforts towards a systematic evaluation of the multiple genetic association studies for Alzheimer's disease, while the first genome-wide association studies are now being reported with promising results. As sample sizes grow through new collections and collaborative efforts, and as new technologies make it possible to test alternative hypotheses, it is expected that new genes involved in the disease will soon be identified and confirmed. The gene discoveries of the 1990s have taught us a lot about Alzheimer's disease pathogenesis, providing many therapeutic targets that are currently at various stages of testing for future clinical use. As new genes become known and the biological pathways leading to disease are further explored, the possibility of prevention and successful personalized treatment is becoming tangible, providing hope for the millions of patients with Alzheimer's disease and their caregivers.",
author = "Dimitrios Avramopoulos",
year = "2009",
month = "3",
day = "27",
doi = "10.1186/gm34",
language = "English (US)",
volume = "1",
journal = "Genome Medicine",
issn = "1756-994X",
publisher = "BioMed Central",
number = "3",

}

TY - JOUR

T1 - Genetics of Alzheimer's disease

T2 - Recent advances

AU - Avramopoulos, Dimitrios

PY - 2009/3/27

Y1 - 2009/3/27

N2 - Alzheimer's disease is a progressive neurodegenerative disorder with high prevalence in old age.t is the most common cause of dementia, with a risk reaching 50% after the age of 85 years, and with the increasing age of the population it is one of the biggest healthcare challenges of the 21st century. Genetic variation is an important contributor to the risk for this disease, underlying an estimated heritability of about 70%. Alzheimer's genetics research in the 1990s was successful in identifying three genes accounting for most cases of early-onset disease with autosomal dominant inheritance, and one gene involved in the more common late-onset disease, which shows complex inheritance patterns. Despite the presence of significant remaining genetic contribution to the risk, the identification of genes since then has been elusive, reminiscent of most other complex disorders. In the past decade there have been significant efforts towards a systematic evaluation of the multiple genetic association studies for Alzheimer's disease, while the first genome-wide association studies are now being reported with promising results. As sample sizes grow through new collections and collaborative efforts, and as new technologies make it possible to test alternative hypotheses, it is expected that new genes involved in the disease will soon be identified and confirmed. The gene discoveries of the 1990s have taught us a lot about Alzheimer's disease pathogenesis, providing many therapeutic targets that are currently at various stages of testing for future clinical use. As new genes become known and the biological pathways leading to disease are further explored, the possibility of prevention and successful personalized treatment is becoming tangible, providing hope for the millions of patients with Alzheimer's disease and their caregivers.

AB - Alzheimer's disease is a progressive neurodegenerative disorder with high prevalence in old age.t is the most common cause of dementia, with a risk reaching 50% after the age of 85 years, and with the increasing age of the population it is one of the biggest healthcare challenges of the 21st century. Genetic variation is an important contributor to the risk for this disease, underlying an estimated heritability of about 70%. Alzheimer's genetics research in the 1990s was successful in identifying three genes accounting for most cases of early-onset disease with autosomal dominant inheritance, and one gene involved in the more common late-onset disease, which shows complex inheritance patterns. Despite the presence of significant remaining genetic contribution to the risk, the identification of genes since then has been elusive, reminiscent of most other complex disorders. In the past decade there have been significant efforts towards a systematic evaluation of the multiple genetic association studies for Alzheimer's disease, while the first genome-wide association studies are now being reported with promising results. As sample sizes grow through new collections and collaborative efforts, and as new technologies make it possible to test alternative hypotheses, it is expected that new genes involved in the disease will soon be identified and confirmed. The gene discoveries of the 1990s have taught us a lot about Alzheimer's disease pathogenesis, providing many therapeutic targets that are currently at various stages of testing for future clinical use. As new genes become known and the biological pathways leading to disease are further explored, the possibility of prevention and successful personalized treatment is becoming tangible, providing hope for the millions of patients with Alzheimer's disease and their caregivers.

UR - http://www.scopus.com/inward/record.url?scp=77953448164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953448164&partnerID=8YFLogxK

U2 - 10.1186/gm34

DO - 10.1186/gm34

M3 - Article

C2 - 19341505

AN - SCOPUS:77953448164

VL - 1

JO - Genome Medicine

JF - Genome Medicine

SN - 1756-994X

IS - 3

M1 - gm34

ER -